معرفی
Hai Feng Zhang is an Associate Research Scientist in the Department of Pathology at Yale University School of Medicine. His research focuses on vascular biology and inflammation-driven diseases, particularly exploring mechanisms of endothelial dysfunction in conditions like atherosclerosis and cerebral cavernous malformations (CCM). He holds a PhD from the National University of Singapore and degrees from China Agricultural University.
Education:
- PhD, National University of Singapore
- MS, China Agricultural University, Endocrinology
- BS, China Agricultural University, Biochemistry and Physiology
Research Interests:
His work investigates how inflammatory signals (e.g., TNF) and reactive oxygen species disrupt endothelial homeostasis. Key areas include:
- Molecular mechanisms of vascular inflammation
- Role of SUMOylation in vascular remodeling
- Mitochondrial dysfunction in endothelial pathologies
- CCM pathogenesis and therapeutic targets
Key Contributions: Recent studies have uncovered roles for SRF SUMOylation in smooth muscle differentiation and identified mitochondrial pathways (TRX2, ATPIF1) critical for vascular health. Collaborations with teams like the Jenny Zhou Lab advance understanding of brain endothelial progenitor signaling and CCM development.
Labs/Teams: Active member of the Jenny Zhou Lab, collaborating on translational vascular research projects.
