معرفی
Robert Shenkar is a Research Professor in the Department of Neurological Surgery at the University of Chicago. His work focuses on cerebral cavernous malformations (CCMs), a vascular disorder of the brain. He investigates signaling pathways, therapeutic interventions (e.g., ROCK inhibition, statins), and biomarkers (e.g., imaging, plasma molecules) for CCM progression and hemorrhage. His research employs murine models, advanced imaging techniques (MRI), and molecular biology tools.
- Education: PhD in Biophysics from the University of Michigan (1979), postdoctoral training in Molecular Biology, Pulmonary Medicine, and Neurological Surgery at institutions including Cornell University and UCLA.
- Research Interests: CCM pathogenesis, ROCK signaling, inflammation-driven lesion formation, and translational therapeutics.
- Key Projects: ROCK inhibitors' efficacy in CCM models; biomarker development via imaging (quantitative susceptibility mapping, DCE-MRI); immune response characterization (B-cell depletion studies).
- Publications: Over 100 peer-reviewed articles on CCM mechanisms, therapeutic strategies, and clinical biomarkers.
- Collaborations: Works with teams at University of Chicago and global institutions on clinical trials (e.g., AT CASH EPOC) and basic science studies.
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