معرفی
Dr. Elias Hobeika is a Group Leader specializing in B cell biology, focusing on survival mechanisms and signaling pathways in mature B cells. His research investigates how deletion of components of the B cell antigen receptor (BCR) and its signaling machinery affects cellular homeostasis, utilizing Tamoxifen-inducible B cell-specific Cre strains to manipulate "floxed" alleles like immunoglobulin heavy chain, Iga, Igb, and Syk. His work aims to translate findings to human B cells in lymphatic disorders and murine models of malignant B cell development.
Key research areas:
- B cell antigen receptor (BCR) signaling
- BAFF-R mediated survival pathways
- Role of Syk, PI3K, and ATM-p53 in B cell homeostasis
- Mouse models for B cell lymphomas
- Translational studies in human lymphatic disorders
Recent publications (2010–2016) reveal consistent focus on:
- Signal transduction in B cell development
- Kinase/phosphatase equilibrium in malignant transformation
- Chemotaxis mechanisms via CXCR4 and ZAP-70
- Regulation of terminal differentiation by oncogenic factors
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Elias Hobeika در سایتهای دیگر
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