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Prof. Dr. Henning Jacob Jessen holds the Chair of Bioorganic Chemistry at the University of Freiburg's Institute of Organic Chemistry. His research integrates chemistry and biology to investigate cellular phosphate conjugates, including inositol pyrophosphates, magic spot nucleotides, and condensed phosphates. Research focuses on developing chemical tools for biological studies, metabolic pathway analysis, and therapeutic applications. Key areas include enzymatic synthesis of phosphate derivatives, metabolic flux analysis, structural biology of phosphate transporters, and inhibitor design for kinases. Recent publications demonstrate innovation in: Advanced LC-MS methods for metabolite profiling Chemoenzymatic synthesis of inositol derivatives Structural mechanisms of phosphate transporters Mathematical modeling of metabolic flux Development of kinase inhibitors with therapeutic potential He leads a large research group with multiple postdoctoral researchers and PhD students investigating phosphate biochemistry across biological systems.

• Bioorganic Chemistry
• Inositol Pyrophosphates
• Magic Spot Nucleotides
• +۳ مورد دیگر

Prof. Dr. Dorothea Fiedler is the Head of the Fiedler Group and Managing Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin, Germany. Her research is situated within the Research Section of Chemical Biology, where she leads a multidisciplinary team investigating the role of inositol polyphosphates and pyrophosphates in cellular signaling and metabolism. Her research interests lie at the intersection of chemistry and biology, focusing on understanding how phosphate-based molecules regulate cell homeostasis and how their dysregulation contributes to diseases such as cancer, diabetes, and obesity. She employs techniques from organic chemistry, chemical genetics, proteomics, and cell biology to develop novel tools like activity-based probes and biosensors for studying these signaling networks. Although specific recent publications are not listed in the provided text, her group's work consistently centers on the signaling-metabolism interface, particularly protein pyrophosphorylation and the functional annotation of inositol phosphates, reflecting a strong trend in chemical biology and molecular pharmacology. Scientific Awards: None listed in the provided text. Prof. Fiedler has mentored numerous PhD students and postdoctoral researchers, many of whom have gone on to complete their degrees under her supervision. Her group actively recruits new PhD candidates and postdocs, indicating ongoing research projects and likely grant funding, although specific grants are not mentioned. She previously held an academic position at Princeton University before relocating her lab to FMP in Berlin. The Fiedler Group is embedded within the FMP’s Chemical Biology research section and collaborates with core facilities such as Mass Spectrometry, NMR, Screening Unit, Peptide Chemistry, and Cryo-EM, enabling a comprehensive and technologically advanced research environment.

• Chemical Biology
• Signal Transduction
• Inositol Phosphates
• +۷ مورد دیگر

Ingrid Span is a Professor of Bioinorganic Chemistry at the Department of Chemistry and Pharmacy, Friedrich-Alexander University Erlangen-Nuremberg (FAU). Her research group investigates the chemistry of biocatalysts, focusing on sustainable energy production, bioremediation, and strategies to combat bacterial/viral infections. The team employs multidisciplinary approaches spanning molecular biology, spectroscopy, and macromolecular crystallography. Research areas include Bioinorganic Chemistry , Sustainable Energy , and Antimicrobial Development . Key methods: Protein Crystallography , Spectroscopy , and Biophysical Analysis . Contact: ingrid.span@fau.de , Room A2.37, Egerlandstr. 1, 91058 Erlangen.

• Bioinorganic Chemistry
• Sustainable Energy Production
• Bioremediation
• +۷ مورد دیگر

Prof. Henning Jessen is a Full Professor of Bioorganic Chemistry at the Institute of Organic Chemistry, part of the Faculty of Chemistry and Pharmacy at the University of Freiburg. He serves as Coordinator of Research Area B and Principal Investigator for Research Areas B and C. His work focuses on chemical biology, phosphate homeostasis, inorganic polyphosphate, nucleotides, and inositol pyrophosphates. Research projects include investigating phase separation in living materials, chemically fueled adaptive materials, and dissipative systems engineering. Key collaborations involve livMatS initiatives such as Logic Self-Reporting Mechano-Adaptive Metamaterials. Jessen supervises doctoral researchers Vanessa Barth and Dr. Alexander Ripp. His research highlights spontaneous peptide elongation mechanisms, hierarchical mechanical transduction in DNA hydrogels, and the synthesis of stable isotope-labeled mRNA caps for sensitive tissue analysis. His work bridges organic chemistry with biological systems, emphasizing phosphate-based signaling and material engineering. Publications span topics like enzymatic mechanisms, polyphosphate kinases, and synthetic nucleotide analogs. Awards and grants are not explicitly listed, but his projects are funded by DFG’s Excellence Strategy.

• Chemical Biology
• Phosphate Homeostasis
• Inorganic Polyphosphate
• +۳ مورد دیگر

Dorothea Fiedler is a Professor of Chemical Biology at Humboldt University Berlin and Head of the Chemical Biology I department at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) since 2015. She previously held an Assistant Professor position at Princeton University (2010-2015) and conducted postdoctoral research at the University of California, San Francisco (2006-2010). Education: Diplom in Chemistry, Julius-Maximilians Universität Würzburg (2001) Ph.D. in Chemistry, University of California at Berkeley (2005) Her research focuses on chemical biology, particularly inositol phosphate metabolism, pyrophosphorylation mechanisms, and the development of chemical tools to study protein signaling and metabolic networks. She has pioneered chemoenzymatic synthesis methods for inositol pyrophosphates and created fluorescent sensors for detecting pyrophosphorylated proteins. Her recent publications highlight advancements in understanding inositol phosphate messengers using NMR spectroscopy, non-hydrolyzable analogs, and chemical derivatization techniques. These works bridge organic chemistry, biochemistry, and systems biology to unravel molecular signaling pathways. Scientific Awards: NIH Director’s New Innovator Award (2013) Rita Allen Scholar Award (2013) Kimmel Scholar Award (2013) NIH Pathway to Independence Award (2009) Fasttrack Program, Robert Bosch Stiftung (2007) Schering Stiftung Postdoctoral Fellowship (2007) Young Investigator Award (ACS Inorganic Division) (2005) Bayer AG Fellowship (for Diploma thesis abroad) (2000) German National Merit Foundation (Studienstiftung des Deutschen Volkes) (1998) Fiedler serves as Managing Director of the FMP since 2017 and is a PI in the Cluster of Excellence UniSysCat. She contributes editorially to ChemBioChem and ACS Chemical Biology , emphasizing her leadership in chemical biology research.

• Chemical Biology
• Biochemistry
• Organic Chemistry
• +۶ مورد دیگر