جست‌وجوی استاد و پژوهشگر

Matthew Zinkgrafمشاهده پروفایل

دانشیار

• Ecological Genetics
• Evolutionary Genomics
• Plant Biology
• +۳ مورد دیگر

Matthew Zinkgraf is an Associate Professor in the Biology Department at Western Washington University (WWU), part of the College of Science and Engineering. His research focuses on ecological and evolutionary genetics of plants, integrating computational biology, molecular biology, and forest ecology. He holds a B.S. in Biology and Natural Resource Management from the University of Wisconsin-Stevens Point (2001), an M.S. in Natural Resources (2004), and a Ph.D. in Biology from Northern Arizona University (2012). Postdoctoral fellowships included work at the U.S. Forest Service and the NSF Plant Genome Research Program. His lab explores genetic variation in forest trees, adaptation mechanisms, and ecologically important traits like wood formation and stress resistance. His work emphasizes interdisciplinary approaches, including genomic and computational methods to study tree genetics. Notable research themes include landscape-scale genetic structuring, evolutionary processes influencing adaptation, and the genetic basis of economically relevant traits. Zinkgraf is also an advocate for mentorship in science, reflecting his own journey as a first-generation student. Outside academia, he is an outdoor enthusiast, woodworker, and fly-fishing enthusiast, often combining craftsmanship with scientific curiosity. Publications highlight studies on Populus species, ectomycorrhizal fungi interactions, and genetic modifiers in neurodegenerative disease models. His research bridges fundamental biology with applied challenges in forest ecosystems and climate resilience.

• Metabolic Disease
• Systems Biology
• Insulin Signaling
• +۴ مورد دیگر

Professor David E James is the Leonard P Ullmann Chair of Metabolic Systems Biology at the Charles Perkins Centre, University of Sydney. He holds concurrent professorial positions in the School of Life and Environmental Sciences and School of Medical Sciences. His research focuses on understanding metabolic diseases through systems biology approaches, particularly insulin signaling pathways and gene-environment interactions. His academic journey includes a PhD from UNSW (1985), postdoctoral work at Boston University and Washington University, and leadership roles at the Garvan Institute and Charles Perkins Centre. He has supervised 32 PhD students and mentored 42 early career researchers. Research interests span metabolic disease mechanisms, protein phosphorylation networks, and translational strategies for diabetes prevention. Notable achievements include pioneering methods to measure insulin action in vivo and identifying novel targets for metabolic drug development. Major awards include the NSW Premier’s Medical Research Prize (2016) and Fellowship of the Australian Academy of Science (2007). His lab collaborates internationally with groups studying model organisms (flies, mice) and clinical cohorts to bridge basic science and human health applications. Current projects include: Phosphoproteomic analysis of insulin resistance Exercise-induced metabolic adaptations Genetic modifiers of metabolic health His work integrates multi-omics data to uncover deterministic features of metabolic systems, with implications for precision medicine and food technology innovation.

Lisa R Beutlerمشاهده پروفایل

استادیار

• Neuroendocrinology
• Energy Balance
• Metabolism
• +۳ مورد دیگر

Lisa R. Beutler, MD, PhD, is an Assistant Professor at Northwestern University Feinberg School of Medicine in the Department of Medicine (Endocrinology, Metabolism and Molecular Medicine). She earned her MD and PhD at the University of Washington and completed residency and fellowship training in internal medicine and endocrinology at the University of California San Francisco. Board Certifications: Internal Medicine, Endocrinology, Diabetes & Metabolism Hospital Affiliations: Northwestern Memorial Hospital, Jesse Brown VA Medical Center Her research focuses on gut-brain communication mechanisms in energy balance regulation, using optogenetics, chemogenetics, and calcium imaging in genetically modified mice. Key publications include studies on AgRP neuron dynamics, gut motility circuits, and dopamine-related schizophrenia symptoms. Scientific Awards: Kavli Fellow, National Academy of Sciences (2022, 2023, 2024) Helmholtz Young Investigator in Diabetes (HeIDi) (2023) American Diabetes Association Pathway to Stop Diabetes Award (2022) Professional Service: Editorial Board Member, Diabetes (2023–Present) Reviewer, American Diabetes Association (2023–Present) Member, Kavli Frontiers of Science Organizing Committee (2022–2024) Dr. Beutler's industry relationships include ownership/investment interests in Eli Lilly and Company, disclosed under Northwestern University Feinberg's integrity policies.

Joanna Florosمشاهده پروفایل

استاد

• Surfactant Biology
• Pulmonary Physiology
• Respiratory Genetics
• +۳ مورد دیگر

Joanna Floros serves as an Evan Pugh Professor in the Department of Cellular and Molecular Physiology at the Penn State College of Medicine, Hershey Medical Center. Her research program bridges pulmonary physiology, immunology, and genetics with clinical applications in respiratory diseases. Her primary research focuses on surfactant protein biology, particularly SP-A, examining genetic polymorphisms (SNPs), sex-specific differences, and molecular mechanisms in lung immunity. Key areas include respiratory distress syndrome in preterm infants, acute respiratory failure in children, idiopathic pulmonary fibrosis, and responses to pathogens like Klebsiella pneumoniae. Her work integrates molecular biology, proteomics, and transgenic mouse models to investigate how surfactant protein variants regulate alveolar macrophage function, inflammatory responses, and disease susceptibility. Analysis of her 15 most recent publications reveals strong trends in genetic association studies (particularly SNP-SNP interactions), sex-based differences in lung disease outcomes, and translational applications of surfactant protein research across pediatric and adult populations. Her work spans basic science (miRNome analysis, toponome mapping) to clinical correlations (vulvodynia proteomics, respiratory syncytial virus severity). Scientific Awards No specific scientific awards were documented in the provided information. Advising and Grants Dr. Floros maintains an active research program with extensive collaborative networks, as evidenced by her consistent publication record with multidisciplinary teams. While specific grant details aren't provided, her work involves substantial NIH-funded research on surfactant proteins and respiratory diseases. Her advising role is reflected through numerous co-authorships with junior researchers across multiple institutions. Laboratory and Research Teams Her laboratory at Penn State College of Medicine employs integrated approaches combining molecular genetics, proteomics, and animal models to study surfactant protein functions. Key collaborators include David S. Phelps, Vernon M. Chinchilli, and Chintan K. Gandhi, with research spanning pulmonary immunology, genetic epidemiology, and sex-specific disease mechanisms.

Laurine Levillayerمشاهده پروفایل

پژوهشگر

• Immunology
• Virology
• Molecular Biology
• +۳ مورد دیگر

Laurine Levillayer is a Researcher at Institut Pasteur , focusing on immunology and virology projects. Her work spans T-cell immunity , flavivirus infections , and vaccine development for pathogens like SARS-CoV-2 , Zika virus , and Dengue virus . Her research includes: Developing DNA vaccines targeting immunodominant T-cell epitopes for flaviviruses. Elucidating SKAP2 protein architecture and its role in SRC kinase interactions and cell signaling . Investigating B-cell dynamics in tocilizumab-treated convalescent patients during the COVID-19 pandemic . Key trends in her publications include molecular mechanisms of immune crosstalk , protein interactome analyses, and transgenic mouse models for viral immunity. Her work emphasizes cellular and molecular aspects of host-pathogen interactions and vaccine efficacy without neutralizing antibodies .

• Computational Biology
• Algorithm Development
• High-Throughput Data Analysis
• +۵ مورد دیگر

Oliver D. King is an Assistant Professor in the Department of Neurology at the University of Massachusetts Chan Medical School, where he leads research in computational biology focused on facioscapulohumeral muscular dystrophy (FSHD). He also holds appointments in the NeuroNexus Institute and the Morningside Graduate School of Biomedical Sciences Department of Neuroscience, contributing to the institution's Wellstone Program dedicated to muscular dystrophy research. Dr. King received his BA in Mathematics from the University of Hawaii at Manoa, followed by an MS in Computer Sciences and a PhD in Mathematics, both from the University of California, Berkeley. His academic journey included postdoctoral training at Harvard Medical School and the Whitehead Institute before joining the Boston Biomedical Research Institute as a Scientist. He transitioned to academia at UMass Chan Medical School in 2013, first in Cell and Developmental Biology before moving to Neurology in 2016. As a computational biologist, Dr. King specializes in algorithm development and high-throughput data analysis with a primary focus on FSHD. His research investigates transcriptional and epigenetic changes associated with the disease, genetic modifiers of severity, and therapeutic approaches targeting the DUX4 gene. He has developed several computational tools including PLAAC for identifying proteins with prion-like domains, D4Z4caster for FSHD analysis, and RFF for behavioral analysis in animal models. Analysis of Dr. King's publication record reveals a strong interdisciplinary approach that bridges mathematics, computer science, and biomedical research. His work spans computational biology, molecular genetics, and neuroscience, with significant contributions to understanding prion-like domains in neurodegenerative diseases and developing gene therapy approaches for muscular dystrophies. His recent publications demonstrate increasing focus on translational applications of computational findings to therapeutic development. Dr. King leads a multidisciplinary research team within the Wellstone Program at UMass Chan Medical School. His laboratory combines computational approaches with experimental validation, bringing together expertise in bioinformatics, molecular biology, and clinical research to advance understanding of FSHD pathogenesis and develop targeted interventions for this complex neuromuscular disorder.

• Muscular Dystrophies
• Trinucleotide Repeat Expansion
• Comparative Genomics
• +۱ مورد دیگر

Robert B. Weiss is a PhD faculty member in the Department of Human Genetics, focusing on muscular dystrophies, trinucleotide repeat expansion, comparative genomics, and addiction-related research. His career spans over two decades, with significant contributions to understanding genetic mechanisms in neuromuscular disorders. PhD in Genetics from the University of Washington BS in Biology from the Massachusetts Institute of Technology His research explores genetic mutations in muscular dystrophies, including D4Z4 and CTG repeat expansions, and extends to comparative genomics and addiction genetics. He has co-authored numerous studies on gene therapy applications, mutation detection, and disease phenotypes. Recent publications highlight work on facioscapulohumeral dystrophy, exon-skipping therapies for Duchenne muscular dystrophy, and population-based screening for myotonic dystrophy. Collaborations include the Italian DMD Network and the United Dystrophinopathy Project.

Michael Hendersonمشاهده پروفایل

دانشیار

• Parkinson’s disease
• Neurodegenerative disease models
• α-synuclein pathology
• +۴ مورد دیگر

Dr. Michael Henderson is an Associate Professor in the Department of Neurodegenerative Science at Van Andel Institute (VAI) and Director of the VAI Brain Bank. His research focuses on neurodegenerative diseases like Parkinson’s and dementia with Lewy bodies (DLB), investigating protein pathologies (e.g., α-synuclein, tau) and genetic risk factors (e.g., LRRK2, GBA1). He earned his B.Sc. in Biological Science from Florida State University, Ph.D. in Neuroscience from Yale University (under Dr. Sreeganga Chandra), and conducted postdoctoral work at the University of Pennsylvania (with Drs. Virginia Lee and John Trojanowski). Promoted to Associate Professor in 2024, his lab combines primary neuron cultures, animal models, and computational modeling to study disease mechanisms and therapeutic targets. Key research areas include: (1) Mapping α-synuclein pathology spread via brain connectivity networks, (2) Evaluating LRRK2 kinase inhibitors and glucocerebrosidase modifiers, (3) Identifying cell-type vulnerabilities using spatial transcriptomics, and (4) Translating discoveries into clinical trials. His lab has published over 120 peer-reviewed papers, including 63 in high-impact journals (2024 alone). Notable grants include a $5.8M NIH grant (2025) studying cellular senescence in Parkinson’s and a $9M Aligning Science Across Parkinson’s award (2021). Awards include the NSF Graduate Research Fellowship (2012) and NIH Ruth L. Kirschstein Award (2017). His team includes 10+ advisees (Ph.D. students, postdocs, and technicians), with active collaborations across institutions like Yale and the University of Pennsylvania. The Henderson Lab aims to accelerate therapies by bridging basic science and clinical applications.

Rosemary Akhurstمشاهده پروفایل

استاد

• Cancer Biology
• TGFβ Signaling
• Immunotherapy
• +۴ مورد دیگر

Rosemary Akhurst is a Professor of Anatomy at the University of California San Francisco (UCSF), affiliated with the Helen Diller Family Comprehensive Cancer Center. Her research focuses on TGFβ signaling in cancer, development, and vascular biology. She leads studies on tumor microenvironment dynamics, cancer immunotherapy, and Hereditary Hemorrhagic Telangiectasia (HHT). As Faculty Director of the NCI-sponsored Preclinical Therapeutics Core (PTC), she oversees advanced imaging and therapeutics technologies for cancer research. Education includes a BSc (Hons) in Biochemistry from Imperial College London (1975-1978) and a PhD in Molecular Biology from the Beatson Institute for Cancer Research (1978-1981). Awards include the Ewart Stickings Award, EMBO Fellowship, and UCSF Mentoring Award. Research interests span translational approaches targeting TGFβ signaling in immunotherapy, genetic modifiers of cancer therapies, and vascular stability. Collaborative studies on HHT explore germline mutations and environmental factors influencing disease progression. Her work has contributed to clinical trials of anti-TGFβ agents by Novartis and Pfizer. Recent grants include leadership roles in NIH-funded initiatives focusing on cellular plasticity, vascular biology, and patient-derived xenograft models. She holds over 20 years of continuous funding for studies on TGFβ's role in cancer and vascular disorders. Key contributions include defining TGFβ's dual roles in tumor suppression and progression, elucidating mechanisms of EMT and cancer stem cell maintenance, and developing tools for preclinical therapeutics evaluation across UCSF cancer campuses.

Joshua M Shulmanمشاهده پروفایل

استاد

• Alzheimer's Disease
• Parkinson's Disease
• Functional Genomics
• +۷ مورد دیگر

Joshua M Shulman, M.D., Ph.D., is a Professor at Baylor College of Medicine, where he holds joint appointments in Neurology, Neuroscience, and Molecular & Human Genetics. He is also an Investigator at the Jan and Dan Duncan Neurological Research Institute (DNRI) at Texas Children’s Hospital and Co-Director of the DNRI. His research integrates human genetics, functional genomics, and Drosophila model systems to study Alzheimer’s and Parkinson’s diseases, focusing on genetic mechanisms underlying neurodegeneration and aging. Dr. Shulman’s education includes a Medicine MD from Harvard Medical School (2005) and a PhD in Biochemical Sciences from the University of Cambridge (2000). He completed postdoctoral training in neurogenetics and clinical fellowships in movement disorders at Harvard-affiliated institutions. His research interests include: functional genomics of neurodegenerative diseases, integrative genetic analyses in humans and Drosophila, endolysosomal sorting pathways, RNA metabolism, and translational applications of genomic data. Recent work emphasizes longitudinal omics studies in disease models and precision medicine through whole-genome sequencing in clinical settings. Publications highlight advancements in tauopathy mechanisms, lysosomal dysfunction, and cross-species validation of Alzheimer’s risk genes. His team’s work bridges basic and clinical research, with implications for therapeutic targets in neurodegenerative diseases.

Per Svenningssonمشاهده پروفایل

استاد

• Neurology
• Neurosciences
• Parkinson's Disease
• +۴ مورد دیگر

Per Svenningsson is a Professor of Neurology and Senior Physician at the Department of Clinical Neuroscience, Karolinska Institutet, and leads the Neuropharmacology research group focusing on movement disorders, particularly Parkinson's disease. He holds appointments at Karolinska University Hospital and is affiliated with the Biopark cohort and multiple collaborative initiatives. His research integrates clinical, translational, and experimental approaches to understand disease mechanisms and develop biomarkers. Education: MD (1996) and PhD (1998) from Karolinska Institutet. Research expertise spans neuropharmacology, neurodegeneration, and psychiatric comorbidities like depression. He leads projects on Parkinson's non-motor symptoms, biomarker development, and clinical trials for disease-modifying therapies. Research interests include: Pathophysiology of Parkinson's disease Biomarkers and early diagnosis Neurochemical changes in L-DOPA-induced dyskinesia Role of glial cells and lipid homeostasis Novel drug targets using mass spectrometry imaging Key publications focus on parkinsonism models, computational memory capacity, and molecular mechanisms in depression. His work has been supported by grants from the Swedish Research Council, Wallenberg Foundation, and international initiatives like ASAP for Parkinson's research. Advising includes supervision of PhD students Behzad Iravani and Lovisa Brodin. Collaborations involve teams across neurology, psychiatry, and bioinformatics, emphasizing multidisciplinary approaches to neurodegenerative diseases. Labs/Teams: Neuropharmacology - Movement Disorders group at Karolinska Institutet, contributing to the Biopark cohort and international clinical trials (e.g., Montelukast for Parkinson's neuroinflammation).

Melissa J. Spencerمشاهده پروفایل

استاد

• Muscular Dystrophy
• Gene Therapy
• CRISPR
• +۴ مورد دیگر

Melissa J. Spencer is a Professor in the Department of Neurology at the University of California Los Angeles (UCLA) School of Medicine. Her research focuses on muscular dystrophies , particularly Duchenne muscular dystrophy (DMD) and limb girdle muscular dystrophies (LGMDs) , with an emphasis on gene therapy , CRISPR applications , and immune modulation in therapeutic contexts. Principal Investigator on multiple NIH grants including R01NS117912 (2020-2025) for AAV vector optimization Co-Principal Investigator on NIH RC1AR058333 (2009-2011) for exon skipping research Research Trends in her recent publications span: Gene Delivery Systems (AAV, nanoparticles, CRISPR strategies) Immune Response Analysis in gene therapy recipients Muscle Fibrosis mechanisms and macrophage polarization Therapeutic Development for LGMD and DMD Her work integrates molecular biology , genomics , and clinical applications to address degenerative muscle conditions.

Frédéric Rieux-Laucatمشاهده پروفایل

استاد پژوهشی

• Immunology
• Autoimmune Diseases
• Immunodeficiencies
• +۵ مورد دیگر

Frédéric Rieux-Laucat is a Research Professor and Team Leader at the Institut Imagine , focusing on the immunogenetics of pediatric autoimmune diseases. His work explores mechanisms underlying self-tolerance defects in primary immunodeficiencies and hyperimmune syndromes, with a focus on Autoimmune Lymphoproliferative Syndrome (ALPS), IPEX, and severe combined immunodeficiencies (SCID). Key research areas include FAS gene mutations, regulatory T cell dysfunction, STING pathway abnormalities, and cytokine dysregulation in autoimmune pathogenesis. His studies integrate clinical samples from patients with rare immune disorders, alongside animal and cellular models. Recent work has identified genetic modifiers like DOCK11, SOCS1, and PTPN2 in autoimmune onset, and contributed to understanding type I interferon deficiencies in severe COVID-19. He has trained a multidisciplinary team of researchers, including post-doctoral fellows, PhD candidates, and clinical collaborators. Key research themes include molecular mechanisms of lymphocyte apoptosis, regulatory T cell biology, and translational approaches to diagnose and treat immune dysregulation syndromes. His team’s discoveries bridge basic immunology to clinical applications, including biomarker development for primary immunodeficiencies and personalized therapies for autoimmune conditions.

• Autosomal Dominant Polycystic Kidney Disease (ADPKD)
• Drug Discovery
• Genetic Target Identification
• +۳ مورد دیگر

Sorin Fedeles is an Assistant Professor Adjunct in Nephrology at Yale School of Medicine , part of Yale University . He leads a research program focused on target identification and drug discovery for Autosomal Dominant Polycystic Kidney Disease (ADPKD), employing CRISPR/Cas9 screens and single-cell RNAseq. His work includes developing novel models for ER protein folding and collaborating with MIT on therapeutic compounds, securing ~$5.2M in grants. He co-founded academic spinouts and serves as Executive Director of the Polycystic Kidney Disease Outcomes Consortium at Critical Path Institute, leading clinical biomarker and trial simulator projects. Education: PhD in Genetics (Yale University), MBA in Healthcare (Yale School of Management), MS in Biological and Biomedical Sciences (Yale University). Research Interests: ADPKD mechanisms, ER stress pathways, translational drug development, biomarker discovery. His lab explores genetic interactors like VCP and XBP1, with recent studies on Ire1α-Xbp1 modulation and synthetic agents targeting cystic cells. Grants & Awards: Over $5.2M from NIH, DoD, and PKD Foundation; 2019 PKDF Young Investigator Award. Active in peer review for journals like Journal of the American Society of Nephrology and grants committees. Labs & Teams: Leads interdisciplinary teams at Critical Path Institute, collaborating with bioengineering and clinical groups on preclinical trials and drug development pipelines.

Chiara Belliniمشاهده پروفایل

دانشیار

• Cardiovascular Disease
• Biomechanics
• Vascular Remodeling
• +۵ مورد دیگر

Chiara Bellini is an Associate Professor and Associate Chair for Graduate Studies in the Department of Bioengineering at Northeastern University's College of Engineering. Her research focuses on cardiovascular disease mechanisms, particularly cell-mediated growth and remodeling processes affecting tissue mechanics. She leads studies on cardiopulmonary outcomes from smoke exposure and innovative optical monitoring techniques for metastatic cancer cells. Education : PhD (University of Calgary), MSc & BSc (Politecnico di Milano, Italy) Affiliations : Institute for Mechanobiology, Northeastern University Grants : NIH, Department of Homeland Security, National Cancer Institute Research Interests include: Cardiovascular biomechanics and mechanobiology Wildland fire smoke health impacts E-cigarette toxicity assessment Non-invasive tumor cell monitoring Awards : 2024 Faculty Fellow Award 2024 Outstanding Faculty Service Award 2022 NIH ONES Award Advising & Labs : PhD advisees include Ana Vargas (pregnancy-induced vascular remodeling) and Shaobo Yang (CAR NK cell therapies) Labs: Institute for Mechanobiology Future Work : Expanding studies on wildfire smoke's long-term cardiovascular effects and developing bacterial-based immunotherapies.