معرفی
Professor David E James is the Leonard P Ullmann Chair of Metabolic Systems Biology at the Charles Perkins Centre, University of Sydney. He holds concurrent professorial positions in the School of Life and Environmental Sciences and School of Medical Sciences. His research focuses on understanding metabolic diseases through systems biology approaches, particularly insulin signaling pathways and gene-environment interactions.
His academic journey includes a PhD from UNSW (1985), postdoctoral work at Boston University and Washington University, and leadership roles at the Garvan Institute and Charles Perkins Centre. He has supervised 32 PhD students and mentored 42 early career researchers.
Research interests span metabolic disease mechanisms, protein phosphorylation networks, and translational strategies for diabetes prevention. Notable achievements include pioneering methods to measure insulin action in vivo and identifying novel targets for metabolic drug development.
Major awards include the NSW Premier’s Medical Research Prize (2016) and Fellowship of the Australian Academy of Science (2007). His lab collaborates internationally with groups studying model organisms (flies, mice) and clinical cohorts to bridge basic science and human health applications.
Current projects include:
- Phosphoproteomic analysis of insulin resistance
- Exercise-induced metabolic adaptations
- Genetic modifiers of metabolic health
His work integrates multi-omics data to uncover deterministic features of metabolic systems, with implications for precision medicine and food technology innovation.
