جست‌وجوی استاد و پژوهشگر

Timothy Grocottمشاهده پروفایل

مدرس

• Developmental Biology
• Eye Development
• Gene Regulatory Networks
• +۱۲ مورد دیگر

Dr. Timothy Grocott is a Lecturer in Biomedicine at the School of Biological Sciences, University of East Anglia (UEA), where he leads the Grocott Lab. He is an active member of the Cells and Tissues research group and contributes to the Norwich Developmental Biology and Stem Cell Network. He is currently accepting PhD and Research Masters students and is actively involved in both research and teaching. Research Interests: His research focuses on understanding how cells self-organize into complex organs, particularly the developing eye. He investigates gene regulatory networks and signaling pathways (e.g., TGF-β, Wnt, FGF) that govern tissue patterning and morphogenesis. His lab uses a multidisciplinary approach combining chick embryology, human pluripotent stem cell-derived organoids, and computational modeling (e.g., reaction-diffusion systems). Key topics include Pax6 function, Turing networks in retinal development, and the alignment of lens and retina. Recent Research Trends: Analysis of his recent publications reveals a consistent focus on developmental mechanisms, particularly in eye and sensory organ formation. His work integrates molecular biology with computational tools to model self-organization. A central theme is the role of master regulators like Pax6 and how signaling networks translate genetic information into 3D tissue architecture. His research has strong implications for understanding congenital malformations and advancing regenerative medicine. Scientific Awards: Academy of Medical Sciences Springboard Award (2021) Fight for Sight Early Career Investigator Award (2011) Transforming Education Awards - Staff Member of the Year (2022) Teaching and Supervision: Dr. Grocott is Course Director for the MSc in Stem Cells in Development, Disease and Regeneration and Module Organiser for Embryo Development and Stem Cell Biology. He teaches across multiple undergraduate and postgraduate modules, including Cell Biology, Skills for Biologists, and Research Projects. He actively supervises research projects and welcomes inquiries from prospective PhD and Masters students. Laboratory and Research Projects: The Grocott Lab (www.grocottlab.com, @GrocottLab) conducts research funded by the Academy of Medical Sciences, British Heart Foundation, and the Genetics Society. Current and recent projects include studying Pax7+ progenitors in eye development, harnessing self-organisation in human retinal organoids, and investigating c-Myc in eye development. The lab has developed computational tools like the Atlas Toolkit for 3D imaging data registration.

William Smithمشاهده پروفایل

استاد

• Developmental Biology
• Neuroscience
• Molecular Biology
• +۳ مورد دیگر

William Smith is a Professor in the Department of Molecular, Cellular & Developmental Biology at the University of California, Santa Barbara (UCSB). He earned his undergraduate and graduate degrees in Biology from UC Santa Cruz, followed by postdoctoral research at the University of Strasbourg (France) and UC Berkeley. His laboratory focuses on understanding chordate nervous system development and function, using the amphibian Xenopus and tunicate Ciona as model organisms. Key research areas include neural tube closure mechanisms, sensorimotor circuitry, and the evolution of central nervous system structures. Smith's work has advanced understanding of how T-type calcium channels regulate neural tube closure in both Ciona and vertebrates. Recent studies explore glutamate receptor roles in Ciona's sensorimotor circuits and the integration of visual and gravitactic behaviors. His lab employs cutting-edge techniques in neuroimaging, computational biology, and behavioral analysis. Collaborations with groups like the Interdepartmental Graduate Program in Dynamical Neuroscience at UCSB highlight his interdisciplinary approach. Publications since 2024 investigate deep homologies in chordate CNS structures and reveal conserved neural circuit architectures. His research bridges developmental genetics, molecular biology, and neurophysiology, contributing to both basic science and evolutionary biology. The Smith Lab is actively engaged in training graduate students and postdoctoral researchers in these areas.

Jonathan Corcoranمشاهده پروفایل

استاد

• Neuroscience
• Neurodegenerative Diseases
• Retinoic Acid Signaling
• +۵ مورد دیگر

Professor Jonathan Corcoran is a faculty member at King's College London, specifically in the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) as a Professor of Molecular Neurobiology. His research focuses on discovering drugs for central nervous system (CNS) disorders, including Alzheimer’s disease, motoneuron disease, traumatic brain injury, spinal cord injury (SCI), and neuropathic pain. His work centers on retinoic acid (RA) signaling pathways, particularly the retinoic acid receptors (RARs alpha, beta, gamma), with a translational focus on developing RARβ agonists for clinical applications. Key achievements include the development of the orally available RARβ drug KCL 286, which is in Phase II clinical trials for SCI. His research spans drug design, neuroprotection, axonal regeneration, and neuroinflammation modulation. He leads major projects funded by organizations such as the Wellcome Trust, MRC, and NIHR, including a Phase IIA trial for spinal cord injury treatment. His academic roles include affiliations with the Wolfson Sensory, Pain and Regeneration Centre and the NIHR Maudsley Biomedical Research Centre (BRC). He has supervised multiple students and contributed to over 34 peer-reviewed publications, with a focus on mechanisms of neural repair, retinoic acid signaling, and drug efficacy in CNS disorders. His work aligns with UN Sustainable Development Goals related to health and innovation in medicine. Key collaborations include work on exosome-mediated signaling, mitochondrial dynamics, and the role of RARβ in modulating PTEN activity for spinal cord regeneration. His research bridges basic science and clinical translation, aiming to address unmet medical needs in neurodegenerative and traumatic CNS conditions.

Clemens Kieckerمشاهده پروفایل

استاد

• Vertebrate Forebrain Embryogenesis
• Wnt Signaling
• Sonic Hedgehog Signaling
• +۳ مورد دیگر

Professor Clemens Kiecker is a Professor of Neuroscience Education at King's College London's Institute of Psychiatry, Psychology & Neuroscience (IoPPN), with affiliations to the School of Neuroscience, Centre for Developmental Neurobiology, and Department of Anatomy. He serves as Course Lead for the MSci in Neuroscience and chairs the Undergraduate Neuroscience Assessment Sub-board. His research focuses on vertebrate forebrain embryogenesis, particularly the role of Wnt and Sonic Hedgehog signaling pathways in establishing regional identity and compartment boundaries during brain development. He completed his PhD at Heidelberg University, focusing on embryonic axis formation in Xenopus laevis. Key research themes include genetic networks regulating neural progenitor cell behavior, fate determination, and the molecular mechanisms governing cell-cell interactions in the developing brain. His work contributes to Sustainable Development Goals related to quality education and reducing health disparities through insights into neurodevelopmental disorders. Notable contributions include studies on thalamic compartment formation and boundary maintenance. Recent publications highlight interdisciplinary approaches, such as linking type 2 diabetes and Alzheimer's pathology via systematic reviews. Awards include the Teaching Excellence Award 2014 for innovative pedagogy, including science fiction-based embryology modules. He actively collaborates with experts like Professors Anthony Graham and Corinne Houart, and leads projects on fetal alcohol spectrum disorder neurodevelopment and thalamic genetic codes. Professional activities include organizing public lectures, conference participation, and editorial roles. His lab integrates chick and mouse embryology with tissue culture models to dissect signaling pathways' spatial and temporal effects on brain patterning.

Richard Kollmarمشاهده پروفایل

دانشیار

• Molecular Biology
• Neuroscience
• Developmental Biology
• +۶ مورد دیگر

Richard Kollmar, PhD, is an Associate Professor in the Department of Cell Biology at SUNY Downstate Medical Center . His research focuses on molecular genetics of otolith formation in zebrafish and regeneration of spiral ganglion neurons in mice . He combines proteomics, molecular biology, and embryology to study biomineralization and Wnt-Frizzled signaling pathways. Research Interests : Molecular mechanisms of inner ear morphogenesis and regeneration Cross-species proteomics and genetic networks in otolith development Wnt signaling in auditory neuron repair and cochlear implants Publications : 15+ studies on zebrafish otolith proteins (e.g., Sparc) and neuronal regeneration Recent work on neurocritical care milestones and contrast-induced encephalopathy Labs & Teams : Established culture protocols for adult spiral ganglion neurons Collaborates on clinical trials like INTREPID and WAKE-UP

• Reproductive Physiology
• Endocrinology
• Animal Reproduction
• +۴ مورد دیگر

Luis Schütz is an Assistant Professor in the Department of Agriculture, Veterinary and Rangeland Sciences at the University of Nevada, Reno. His research focuses on reproductive physiology and endocrinology in cattle, aiming to enhance reproductive efficiency in beef and dairy production systems through a deep understanding of ovarian function and hormonal regulation. Research Interests: Reproductive physiology of cattle Endocrine regulation of ovarian follicular development Steroidogenesis in granulosa and theca cells Impact of environmental toxins on reproductive health Application of molecular techniques to improve livestock fertility His work integrates cellular and molecular biology approaches to study gene expression, hormonal signaling, and epigenetic regulation in bovine ovarian tissues. A recurring theme in his research is the role of growth factors and hormones such as FSH, IGF-1, BMPs, and asprosin in modulating reproductive outcomes. Publication Trends: Schütz’s research spans from 2015 to 2023, with a strong emphasis on understanding the molecular mechanisms underlying ovarian function in cattle. His studies often involve in vitro cell culture systems and transcriptomic profiling to uncover regulatory pathways. Recent work has explored the roles of novel peptides like asprosin and epigenetic modifications in reproductive performance. Scientific Awards: No specific awards or honors are listed in the provided text. Advising and Grants: While no specific students or grants are mentioned in the provided content, his collaborative publication record suggests active involvement in mentoring and research partnerships. Labs and Teams: Schütz is affiliated with the Department of Agriculture, Veterinary and Rangeland Sciences at the University of Nevada, Reno. His research likely involves collaboration with other faculty, graduate students, and external partners in veterinary and animal science disciplines.

Fumiaki Imamuraمشاهده پروفایل

دانشیار

• Neuroscience
• Olfactory System
• Neurodegenerative Disorders
• +۳ مورد دیگر

Fumiaki Imamura, PhD, MS is an Associate Professor in the Department of Neuroscience and Experimental Therapeutics at Pennsylvania State University's Penn State Neuroscience Institute. His research program focuses on understanding the fundamental mechanisms of olfactory system development and function. Dr. Imamura's research interests center on the molecular and cellular mechanisms underlying olfactory dysfunctions in neurodegenerative disorders and the molecular and cellular mechanisms regulating neuronal circuit formation in the developing brain. His work specifically investigates Olfactory Bulb Neuroscience , Mitral Cells , Mouse Olfactory Bulb , Projection Neurons , Olfactory Sensory Neuron , and Tufted Cell development and function. Analysis of Dr. Imamura's recent publications (2022-2024) reveals a strong focus on olfactory system development, cellular signaling pathways in the olfactory bulb, and the impact of various factors (alcohol exposure, inflammation) on olfactory function. His work bridges basic neuroscience with potential clinical applications for understanding and treating olfactory dysfunctions. Dr. Imamura has received recognition for his teaching excellence, including: Dean's Award for Excellence in Teaching (2021) Dr. Imamura has successfully secured significant research funding from the National Institute on Deafness and Other Communication Disorders (NIDCD), including two major projects: Heterogeneity of mitral cell properties determined by the timing of neurogenesis (2017-2022) Molecular mechanisms regulating mitral cell development (2010-2015) His laboratory employs advanced techniques including electroporation to study neuronal development in mouse models, with particular focus on the olfactory system as a model for understanding broader principles of neural circuit formation.

• Stem Cell Biology
• Developmental Biology
• Cancer Biology
• +۳ مورد دیگر

Thulaj Dattatraya Meharwade is a Research Fellow at the Cardiovascular Institute Operations, Stanford University. His work focuses on stem cell biology and cancer research, particularly the signaling mechanisms in embryonic stem cells and metabolic pathways in pancreatic cancer cells. University: Stanford University Department: Cardiovascular Institute Operations Email: dthulaj@stanford.edu His research explores the role of BMP signaling in inducing the totipotent state in mouse embryonic stem cells, and how FGF, NODAL, and WNT pathways constrain this process. He also investigates metabolic vulnerabilities in pancreatic cancer, specifically the interplay between metformin and NAMPT inhibition. Recent publications highlight his contributions to understanding stem cell heterogeneity and enhancing cancer therapies. His work combines single-cell sequencing and metabolic pathway analysis to address fundamental questions in developmental biology and oncology. ORCID: 0000-0002-2660-9549

• Developmental biology
• Gene Regulation
• Neural Tube Defects
• +۵ مورد دیگر

Michael Stark is a Professor and Associate Dean at the College of Life Sciences , Brigham Young University. His academic contributions span research, teaching, and administration, with a focus on developmental biology and gene regulation in sensory neurogenesis. He chairs the Department of Cell Biology and Physiology and maintains affiliations with the Neuroscience Center , BioUtah , The Brain Institute , and the Society for Developmental Biology .

Utpal Banerjeeمشاهده پروفایل

استاد

• Drosophila genetics
• Developmental biology
• Signal transduction
• +۷ مورد دیگر

Utpal Banerjee is a Distinguished Professor at the University of California, Los Angeles (UCLA), with joint appointments in the Department of Molecular, Cell, and Developmental Biology and the Department of Biological Chemistry. He serves as Co-Director of the UCLA Broad Stem Cell Research Center and has pioneered research using Drosophila as a model for hematopoiesis and signal transduction. Banerjee's work bridges developmental biology, metabolic regulation, and cancer pathways, earning him national recognition and a $1 million HHMI grant to enhance undergraduate science education.

Karen Lyonsمشاهده پروفایل

استاد

• Developmental Biology
• Cell Biology
• Signal Transduction
• +۳ مورد دیگر

Karen Lyons , Ph.D., is a Professor in the Department of Molecular, Cell, and Developmental Biology at the University of California, Los Angeles (UCLA) , with affiliations to the Brain Research Institute , CTSI Cell & Developmental Biology GPB Home Area , JCCC Cancer and Stem Cell Biology Program Area , and Molecular, Cellular & Integrative Physiology GPB Home Area . Her research focuses on growth factor signaling in mammalian development and disease, particularly the roles of the transforming growth factor-β (TGF-β) family and Bone Morphogenetic Protein (BMP) subgroup in cell cycle control, gene expression, and cell-cell interactions. Education : Ph.D. (unspecified field) Research Interests : Investigating TGF-β and BMP signaling in developmental contexts Using mouse models and genetic tools (transgenic, gene targeting) Organ/cell culture systems for receptor signaling mechanisms Recent Publications highlight her work on CCN2/CTGF in cartilage and angiogenesis, BMP-Smad signaling in bone formation, and CCN2's role in cancer . Her studies span Developmental Biology , Cell Biology , and Molecular Genetics , with applications in Physiology and Cancer Research . Contact : klyons@mednet.ucla.edu at the UCLA Orthopaedic Hospital Research Center in Los Angeles, CA.

Robert Knightمشاهده پروفایل

پژوهشگر

• Developmental Genetics
• Muscle Stem Cell Biology
• Craniofacial Development
• +۳ مورد دیگر

Dr. Robert Knight is a Reader in Developmental Genetics at King’s College London, affiliated with the Centre for Craniofacial & Regenerative Biology and Faculty of Dentistry, Oral & Craniofacial Sciences. He obtained his PhD in Molecular Evolution from the University of Reading in 2000, followed by postdoctoral work at UC Irvine and University of Sheffield, focusing on AP-2 genes, neural crest, and cranial muscle development in zebrafish. His research explores molecular regulation of muscle regeneration and stem cell behavior, combining live imaging, transcriptomics, and zebrafish models. Key findings include the role of Ret tyrosine kinase in facial muscle development and FSHD therapy, RhoA coupling migration/differentiation, and NF-κB in macrophage function during repair. Collaborations span systems biology (Dresden), physiology (Amsterdam), and macrophage signaling (Lyon). Recent publications highlight trends in muscle stem cell dynamics , signaling pathways (Wnt, Notch, Ret), and age-related regeneration . His work aligns with SDGs via health (musculoskeletal diseases) and innovation (AI in biosciences, multiphoton microscopy). Scientific Awards: BBSRC Project Award MDUK Studentship NC3Rs Studentship Royal Society Partnership Award Carl Zeiss Collaboration Current projects address DUX4-activated Ret in FSHD, chromatin organization in aging, and macrophage-stem cell interactions . He leads grants from BBSRC, Dunhill Medical Trust, and Leverhulme Trust.

Michael A. Frohmanمشاهده پروفایل

استاد

• Lipid Biology
• Mitochondrial Biology
• Signal Transduction
• +۵ مورد دیگر

Michael A. Frohman is a Professor and Chair in the Department of Pharmacological Sciences at Stony Brook University . He directs the Medical Scientist Training Program and holds fellowships with the American Association for the Advancement of Science (AAAS) and the Association of American Physicians (AAP). His research focuses on lipid signaling pathways, particularly the Phospholipase D (PLD) family and PI4P Kinase , which regulate mitochondrial dynamics, exocytosis, and disease mechanisms in diabetes , cancer , neurodegenerative disorders (Charcot-Marie Tooth syndrome), and immune dysfunction . Alumni from his lab hold faculty positions globally, and he pioneered the 5’ RACE technique during his postdoctoral work at UCSF. Education : M.D., Ph.D., University of Pennsylvania School of Medicine B.S. with Distinction, University of Michigan Research Themes : Lipid signaling in mitochondrial fusion/fission Regulation of exocytosis and endocytosis PLD inhibitors as stroke/cancer therapeutics Neurodegenerative disease mechanisms Diabetes and metabolic signaling Scientific Leadership : Cloned mammalian PLD isoforms Developed mouse models for PLD knockout Coined the 5’ RACE method Notable Awards : Fellow, AAAS Member, AAP

Utthara Nayarمشاهده پروفایل

استادیار

• Cancer Biology
• Cell Biology
• Functional Genomics
• +۵ مورد دیگر

Utthara Nayar, PhD, is an Assistant Professor at Johns Hopkins University's School of Medicine and Bloomberg School of Public Health , with a primary affiliation in the Department of Biochemistry and Molecular Biology . Her research focuses on therapeutic resistance mechanisms in breast and ovarian cancers, particularly mutations in HER2 and FGFR/FGF pathways that drive endocrine therapy resistance. She employs functional genomics, deep mutational scanning, and whole-genome screening technologies to identify tumor cell-intrinsic signaling and therapeutic vulnerabilities. Key research areas include: Therapeutic resistance in breast/ovarian cancer Transcriptional networks in endocrine resistance Oncogene variant-to-function mapping Inflammatory signaling in tumor evolution Genomic/epigenomic approaches Selected publications reveal expertise in: HER2-low subtype resistance (2024) CDK4/6 inhibitor resistance (2023) ATP-competitive drug resistance (2020) Scientific awards include: Ruth L. Kirschstein National Research Service Award (NIH) ASH Abstract Achievement Award Women in Cancer Research Scholar Award (AACR) NCI Transition Career Development Award (K22) Ho-Ching Yang Memorial Fellowship Discovery Award Dr. Nayar leads the Nayar Laboratory, which trains cancer researchers and investigates: Transcriptional control of resistance Oncogene variant functional characterization Therapeutic vulnerabilities in resistant cancers Inflammatory signaling roles Whole-genome screening technologies

• Stem Cell Biology
• Neurodegenerative Diseases
• Regenerative Medicine
• +۳ مورد دیگر

Alrik Schörling is a Research Fellow at the Department of Biomedical Sciences , University of Copenhagen, affiliated with the reNEW initiative and the Kirkeby Lab . His work focuses on stem cell biology and neural differentiation for regenerative medicine applications. Institutional Affiliation : University of Copenhagen Research Focus : Stem cell patterning, dopaminergic neuron development, Parkinson's disease therapy Techniques : FGF17 signaling, cAMP modulation, LMX1A expression studies