Robert Knight

Dr. Robert Knight is a Reader in Developmental Genetics at King’s College London, affiliated with the Centre for Craniofacial & Regenerative Biology and Faculty of Dentistry, Oral & Craniofacial Sciences. He obtained his PhD in Molecular Evolution from the University of Reading in 2000, followed by postdoctoral work at UC Irvine and University of Sheffield, focusing on AP-2 genes, neural crest, and cranial muscle development in zebrafish.

His research explores molecular regulation of muscle regeneration and stem cell behavior, combining live imaging, transcriptomics, and zebrafish models. Key findings include the role of Ret tyrosine kinase in facial muscle development and FSHD therapy, RhoA coupling migration/differentiation, and NF-κB in macrophage function during repair. Collaborations span systems biology (Dresden), physiology (Amsterdam), and macrophage signaling (Lyon).

Recent publications highlight trends in muscle stem cell dynamics, signaling pathways (Wnt, Notch, Ret), and age-related regeneration. His work aligns with SDGs via health (musculoskeletal diseases) and innovation (AI in biosciences, multiphoton microscopy).

• Scientific Awards:
  • BBSRC Project Award
  • MDUK Studentship
  • NC3Rs Studentship
  • Royal Society Partnership Award
  • Carl Zeiss Collaboration

Current projects address DUX4-activated Ret in FSHD, chromatin organization in aging, and macrophage-stem cell interactions. He leads grants from BBSRC, Dunhill Medical Trust, and Leverhulme Trust.