جست‌وجوی استاد و پژوهشگر

Dicky Struikمشاهده پروفایل

پژوهشگر

• Medical Biology
• Biochemistry
• Molecular Biology
• +۳ مورد دیگر

Dr. Dicky Struik is a postdoctoral researcher affiliated with the Faculty of Medical Sciences at the University of Groningen. His work focuses on metabolic regulation, lipid metabolism, and the biological functions of fibroblast growth factors (FGFs), particularly their roles in liver disease and endocrine signaling. He collaborates extensively with researchers in pharmacology, biochemistry, and molecular biology. Research Interests: Struik's primary areas include FGF signaling pathways, bile acid metabolism, and the therapeutic potential of FGF analogs. His studies often utilize mouse models to investigate metabolic disorders such as nonalcoholic fatty liver disease (NAFLD) and explore novel treatments for conditions like neonatal hyperbilirubinemia. Key Contributions: His recent work highlights the pharmacological functions of beta klotho coreceptors, the impact of MEK signaling on bile acid pathways, and the role of GalNAc-T2 glycosylation in energy homeostasis. He has also published reviews synthesizing FGF biology and clinical applications in metabolic diseases. Grants/Advising: While specific grants are not detailed, his research aligns with funding priorities in metabolic health and drug development. No formal advisee list is provided, though he collaborates with multiple researchers listed in his publications. Labs/Teams: Collaborations involve groups at the University Medical Center Groningen (UMCG) and international institutions, focusing on interdisciplinary projects in pharmacology and metabolic research.

• Developmental Biology
• Molecular Embryology
• Cell Signaling
• +۳ مورد دیگر

Professor Betsy Pownall is a Professor and Deputy Head of the Department of Biology at the University of York. Her research focuses on embryonic development mechanisms, particularly using Xenopus and zebrafish models. Key interests include FGF signaling pathways, heparan sulfate proteoglycans (HSPGs), and the role of Sulf1 in regulating developmental processes. She leads a lab investigating skeletal muscle development, transcriptional hierarchies, and the impact of signaling pathways on embryogenesis. Affiliations: University of York, Department of Biology Former Roles: Senior Lecturer, Reader, Lecturer Research explores how signals like FGF and Shh shape cell lineages and tissue formation. Current projects include collaborations on Wnt signaling feedback mechanisms and studies on ZAK-linked myopathies. Teaching spans undergraduate modules in Cell and Developmental Biology, Developmental Biology, and a journal club-style advanced module. She mentors PhD students researching myogenesis, Parkinson’s disease modeling, and adaptations in Alcolapia fish. Grants & Collaborations: BBSRC-funded collaboration with Prof. Stefan Hoppler (Aberdeen) and Prof. Masanori Taira (Tokyo) investigating Wnt signaling. Active in research on metabolic decline and ZAK deficiency’s role in muscle disorders.

• Structural Biology
• Pharmacology
• Receptor Signaling
• +۷ مورد دیگر

Yoshihisa Suzuki is a Senior Research Scientist in the Department of Pharmacology at Yale University's School of Medicine. His research focuses on structural biology, receptor signaling, and drug design, with particular emphasis on understanding the mechanisms of protein interactions and their therapeutic applications. He collaborates extensively with researchers like Francisco Tome, Sangwon Lee, and Joseph Schlessinger, contributing to studies on FGF signaling pathways, receptor tyrosine kinases, and phosphodiesterase inhibitors. Key research themes include the structural basis of ligand-receptor interactions, development of targeted mini-protein inhibitors, and elucidating signaling pathways relevant to oncology and endocrinology. His work bridges fundamental biology with drug discovery, aiming to translate structural insights into clinical applications. No awards or grants are explicitly listed in the provided information. He has advised no formally recorded students but collaborates in mentoring through research projects.

Nicolas Hirschمشاهده پروفایل

دانشیار

• Developmental Neurobiology
• Gene Regulation in Development
• Comparative Embryology
• +۳ مورد دیگر

Nicolas Hirsch is an Associate Professor of Biology and Director of the School of Science & Technology at Hiram College. He holds a Ph.D. in Developmental Neurobiology from the University of California, San Diego, and a B.A. in Biology and Political Science from the University of Chicago. His research focuses on understanding how genetic programs direct the development of complex organs like the brain and eye in vertebrates, particularly using Xenopus and zebrafish as model systems. Key interests include gene regulation during embryogenesis, comparative embryology across species, and the evolution of developmental pathways. Before joining Hiram, Hirsch held positions at Eastern Connecticut State University and conducted postdoctoral research at institutions including the University of Virginia and Dana-Farber Cancer Institute. His work integrates molecular genetics, transgenic technologies, and embryological approaches to study neural and ocular development. He teaches courses such as 'The Science and Ethics of Human Cloning' and coaches Hiram College’s Speech and Debate Team. His research has been published in journals like Developmental Biology and Zebrafish , focusing on topics such as rax gene function in eye field specification, hoxb1-regulated pathways in hindbrain segmentation, and aldh1a2 roles in pancreas development. While no specific awards are listed, his contributions to developmental biology span over two decades with a strong emphasis on model organism systems.

Anne Hannekenمشاهده پروفایل

دانشیار

• Macular Degeneration
• Retinal Cell Biology
• Ophthalmology
• +۵ مورد دیگر

Dr. Anne Hanneken is an Associate Professor of Translational Medicine at The Scripps Research Institute (TSRI), specializing in ophthalmology and macular degeneration research. She holds joint clinical appointments as a Vitreoretinal Surgeon and Vice-President at Retina Consultants San Diego. Her research focuses on improving photoreceptor cell function through drug design, computational modeling, and investigating natural compounds like flavonoids for neuroprotection. Education: B.S. in Chemistry (Marquette University, 1978), M.D. (Medical College of Wisconsin, 1984). Research Interests: Macular degeneration, retinal pigment epithelium biology, oxidative stress, and drug development for vision restoration. Her lab has pioneered breakthroughs such as reviving light signaling in postmortem human retinas (Nature, 2022) and identifying flavonoids' protective roles in retinal cells. Collaborations include the Salk Institute and University of Utah. Awards: Multiple Castle Connolly Top Doctor awards, Marquette University Distinguished Alumnus (2016), Arnold P. Gold Foundation Award (2011). Key grants include NIH/NEI funding. Lab members include Jennifer Johnson (Senior Scientist), Thomas Neikirk (Research Assistant), and Michael Pique (Computer Graphics Director). Ongoing projects explore macular transplantation and allosteric modulators for vision enhancement.

Mark Maconochieمشاهده پروفایل

استاد

• Developmental Neurobiology
• Inner Ear Development
• Deafness Research
• +۴ مورد دیگر

Professor Mark Maconochie is a Professor of Biomedical Sciences at Queen Mary University of London, affiliated with the School of Biological and Behavioural Sciences. He serves as Co-Director of the Nanchang Joint Programme with Nanchang University, China, focusing on Clinical Medicine (Biomedicine). His teaching responsibilities include designing and delivering Cell Biology and Anatomy modules, while he actively integrates emerging technologies into education, such as lecture recordings with Turningpoint software, remote tutorial systems, and electronic assessment platforms. He advocates for student engagement through digital tools, noting evolving generational shifts in technology adoption. His research centers on Developmental Neurobiology, particularly the molecular mechanisms governing inner ear development and deafness. Key contributions include studies on Fibroblast Growth Factor (FGF) and Insulin-like Growth Factor (IGF) signaling pathways, as well as retinoic acid’s role in otic epithelium formation. He also prioritizes animal welfare, striving to minimize research impacts on experimental animals. Recent publications include chapters on FGF regulation in the developing otic epithelium and retinoic acid signaling in the otocyst, both in press, alongside a 2013 study on Gata3’s role in Fgf10 expression. His work bridges basic science and translational applications, addressing critical gaps in understanding sensory organ development and congenital disorders.

Yukiko Yamazakiمشاهده پروفایل

دانشیار

• Reproductive Biology
• Germ Cell Differentiation
• Oocyte Developmental Competence
• +۳ مورد دیگر

Dr. Yukiko Yamazaki is an Associate Professor at the John A. Burns School of Medicine, University of Hawaii , affiliated with the Department of Anatomy, Biochemistry and Physiology and the Yanagimachi Institute for Biogenesis Research . Her work focuses on reproductive biology and assisted reproductive technologies . Education : Master of Veterinary Science (1985) at Rakuno Gakuen University, PhD in Agriculture (1990) at Kitasato University Postdoctoral Training : Mitsubishi Kasei Institute of Life Sciences and National Institute for Physiological Science in Japan Dr. Yamazaki's research investigates germ cell differentiation , oocyte developmental competence , and epigenetic reprogramming of imprinted genes. She pioneered a 3D ovarian tissue culture system using Matrigel and bioinert hydrogel to study follicle growth and fertility preservation for cancer patients. Her publications reveal a focus on in vitro follicle growth , sex differentiation , and germ cell developmental programming . Key methodologies include integrin signaling analysis , FGF9 dose-response experiments , and nuclear transfer techniques . Dr. Yamazaki leads research efforts at the Yanagimachi Institute for Biogenesis Research , where her team examines molecular mechanisms in follicle growth. She has mentored students in the Developmental and Reproductive Biology and Cell and Molecular Biology graduate programs at the University of Hawaii.

Pablo Navarro Gilمشاهده پروفایل

پژوهشگر

• Stem cell biology
• Epigenetics and gene regulation
• Developmental biology
• +۷ مورد دیگر

Pablo Navarro Gil is a Principal Investigator and Structure Manager in the Early Mammalian Embryo and Stem Cells research group at the Institut Pasteur in Paris, France. He leads several major research projects funded by the European Research Council (ERC) and LabEx Revive, focusing on the mechanisms of cell identity preservation during development, particularly through transcription factors, epigenetic regulation, and mitotic bookmarking. University: Institut Pasteur Department: Early mammalian embryo and stem cells Position: Researcher and Principal Investigator Email: pnavarro@pasteur.fr His research centers on stem cell biology and developmental genetics, with a strong emphasis on how gene regulatory networks maintain pluripotency and drive cell differentiation in early mammalian embryos. Key areas include the role of pioneer transcription factors like Nr5a2 and GATA6, the function of nuclear receptors in mitotic bookmarking, and the epigenetic control of gene expression heterogeneity. His recent publications reveal a consistent trend in understanding the molecular choreography of early development, particularly in mouse models. His work integrates chromatin dynamics, transcription factor interactions, and signaling pathways (like PI3K/AKT) to explain lineage specification in the inner cell mass and the inheritance of cellular identity through cell division. ERC-2017-COG_BinD – Mitotic Bookmarking, Stem Cells and early Development (PI) Dr. Navarro Gil mentors several PhD students and postdoctoral fellows, contributing to the training of the next generation of scientists. His laboratory investigates the contribution of long non-coding RNAs and the epigenetic foundation of gene expression heterogeneity, supported by substantial grants from European and French funding bodies. He is an active member of the Stem Cell Initiative and the LabEx Revive consortium, promoting collaborative research in regenerative biology. His team utilizes advanced molecular and cellular techniques to study mouse embryogenesis, with a focus on the pluripotency network and its inheritance during cell division. The research has significant implications for regenerative medicine and understanding developmental disorders.

Angelike Stathopoulosمشاهده پروفایل

استاد

• Developmental Biology
• Molecular Biology
• Genetics
• +۳ مورد دیگر

Angelike Stathopoulos is a Professor of Biology and Director of the Center for Molecular and Cellular Neuroscience at the California Institute of Technology (Caltech). She holds a B.A. from the University of California (1992) and a Ph.D. from Stanford University (1998). Her research focuses on cis-regulatory mechanisms driving embryonic patterning and tissue development in Drosophila , including how transcription factors interact at cis-regulatory modules and coordinate temporal actions of non-contiguous DNA elements. Her lab also investigates how embryonic cell patterning influences cell behaviors during migration and differentiation. Key research areas include enhancer action dynamics, FGF signaling in cell migration, and the interplay between gene regulation and morphogenesis. Her work combines genetics, live imaging, and quantitative approaches to dissect developmental processes. Notable contributions include studies on Dorsal nuclear gradient dynamics, collective cell migration mechanisms, and the role of cis-regulatory modules in spatiotemporal gene expression. Stathopoulos has directed the Stathopoulos Lab at Caltech since 2005, leading a team of researchers exploring developmental biology’s molecular underpinnings. Her findings have advanced understanding of embryo patterning, morphogen gradients, and gene regulatory networks. Grants and collaborations support her lab’s investigations into developmental precision and plasticity. Her lab’s outreach and teaching activities emphasize bridging fundamental research with educational initiatives. The lab website highlights ongoing projects in embryonic gene expression, enhancer coordination, FGF signaling, and collective cell migration.

• Cancer Research
• Molecular Oncology
• Urological Cancers
• +۳ مورد دیگر

Dr Barry Davies is a cancer researcher at Newcastle University with a 16-year publication record (1999-2015) focused on molecular mechanisms in urological and gynecological cancers. His collaborative work spans prostate, bladder, ovarian, and thyroid cancers alongside neuroblastoma studies, primarily within preclinical and translational oncology frameworks. His research centers on: Molecular drivers of metastasis (S100A4, HMGB1) Therapeutic targeting of androgen receptors in prostate/ovarian cancers COX-2 inhibition for bladder cancer immunotherapy Diagnostic biomarkers for thyroid malignancy Mechanisms of tumor necrosis in neuroblastoma Cell death/proliferation pathways in ovarian epithelium Analysis of his publications reveals a consistent focus on bridging molecular discoveries with clinical applications. Key trends include investigating S100A4's role in bladder cancer metastasis, developing mutant androgen receptor models for prostate cancer therapy, and evaluating COX-2 inhibitors to enhance BCG immunotherapy. His work emphasizes translational relevance through preclinical models while highlighting limitations of existing diagnostic markers like Mcm-2/Ki-67 in thyroid cancer.

• Oncology
• Prostate Cancer
• Molecular Biology
• +۳ مورد دیگر

Dr. Steven Darby is an academic researcher affiliated with Newcastle University, specializing in molecular oncology with a focus on prostate cancer mechanisms. His work spans androgen receptor signaling, growth factor pathways, and ubiquitination processes. Research interests include: Molecular drivers of prostate cancer progression (e.g., FGF receptors, Sef inhibitors) Androgen receptor regulation via post-translational modifications (ubiquitination, deubiquitination) Renal inflammation pathways and complement system involvement in fibrosis Biomarker discovery in urological and gynecological cancers His publications (2001–2017) demonstrate consistent collaboration with Newcastle colleagues including Prof. Craig Robson and Dr. Luke Gaughan. No awards, students, or contact details were recorded in the source material.

• Prostate Cancer Research
• Molecular Biology
• Urology
• +۶ مورد دیگر

Dr. Stuart McCracken is a researcher affiliated with Newcastle University , focusing on prostate cancer biology and molecular mechanisms. His work spans diagnostic innovation, therapeutic target identification, and clinical outcomes assessment. Prostate cancer diagnostics and treatment evaluation Androgen receptor signaling pathways Ubiquitin and kinase regulatory networks CRISPR-based genomic studies Clinical-translation research Dr. McCracken’s research explores prostate cancer progression through molecular profiling and signaling pathway analysis. Key areas include: Androgen receptor regulation (via methylation, deubiquitination, and kinase interactions) Target identification in pathways like Hippo, MEK5/ERK5, and PI3K/AKT Clinical decision tools (e.g., MRI-based nomograms) Surgical outcome analysis (focal cryotherapy vs. radical prostatectomy) His recent publications (2020–2023) emphasize CRISPR-engineered models , PARP inhibitor sensitivities , and novel anti-androgen therapies . Earlier work (2005–2011) laid groundwork in growth factor signaling and protein regulation mechanisms.

• Urology
• Urological Oncology
• Prostate Cancer
• +۷ مورد دیگر

Dr. Trevor Dorkin is a researcher at Newcastle University, affiliated with the Faculty of Medical Sciences and the Institute of Cellular Medicine. He has made sustained contributions to urology, particularly in clinical urology, urological oncology, and surgical outcomes. His work spans from molecular pathology to health services research and clinical guidelines. Research Interests: His primary fields include Urology , Prostate Cancer , Urethral Stricture , Testicular Torsion , Laparoscopic Surgery , and Molecular Pathology . His research integrates clinical practice with molecular analysis, aiming to improve diagnostic accuracy and treatment outcomes. The recent publications, including the 2022 BURST-BAUS consensus document and the 2021 OPEN trial cost-effectiveness analysis, reflect a strong trend toward evidence-based practice, guideline development, and health economic evaluation in urological care. Earlier works focus on molecular mechanisms in prostate cancer, showing a long-standing interest in oncological pathways and biomarkers. Dr. Dorkin has collaborated extensively with leading urological researchers such as Professor Christopher Harding, Rob Pickard, and Professor David Neal. While no formal awards are listed, his involvement in high-impact clinical trials and systematic reviews underscores his role in advancing urological science. Advising and Grants: There is no explicit mention of students or grant funding in the provided text. However, his repeated involvement in multi-center studies suggests participation in collaborative research networks and likely access to external funding. Labs and Teams: Dr. Dorkin appears to be part of a broader urological research group at Newcastle University, contributing to both clinical and molecular research streams. His work with the BURST-BAUS group indicates active participation in national consensus-building initiatives in urology.

• Prostate Cancer Research
• Stem Cell Differentiation
• Growth Factor Signaling
• +۷ مورد دیگر

Anne Collins is a prominent researcher at Newcastle University , specializing in prostate cancer biology and epithelial stem cell differentiation. Her work focuses on understanding growth factor signaling, integrin function, and hormone interactions in prostatic epithelium, with significant contributions to in vitro cell culture models and tumor heterogeneity studies. Key collaborations with Professors David Neal, Hing Leung, and Craig Robson Research emphasis on keratinocyte growth factor (KGF) and α2β1-integrin mechanisms Her scientific expertise spans molecular biology, signal transduction, and cancer stem cell identification, with a particular focus on androgen-dependent and hormone-insensitive prostate cancer progression. Recent publications highlight her work on fibroblast growth factor receptors, CD133 as a stem cell marker, and novel therapeutic approaches using 5α-reductase inhibitors. These studies demonstrate her commitment to elucidating tumor biology and developing targeted interventions.

• Evolutionary Developmental Biology
• Vertebrate Limb Evolution
• Comparative Genomics
• +۳ مورد دیگر

Frank Tulenko is a Research Fellow at the Australian Regenerative Medicine Institute (ARMI) at Monash University. His work focuses on evolutionary developmental biology, particularly the origins of vertebrate fins and limbs. Current active projects include investigating the developmental and evolutionary origins of vertebrate fins and limbs (2024-2027) and studying limb musculature evolution (2020-2023). Research interests center on comparative genomics, genetic expression patterns in evolution, and developmental mechanisms underlying appendage formation. Key collaborations involve Prof. Peter Currie and international teams analyzing gene expression across species. Publications emphasize fin evolution mechanisms, including median fin derivation from lateral plate mesoderm and Fgf-Shh signaling in fin growth. Work on epaulette sharks revealed insights into slow evolutionary rates through genomic analysis. Contributions include studies on zebrafish myology and antibody gene evolution in fish immunology. Frank has been consistently productive with 14 documented outputs from 2007-2024, averaging ~1 publication/year. His work frequently appears in high-impact journals like Nature, Nature Ecology & Evolution, and PNAS.