جست‌وجوی استاد و پژوهشگر

Hadley D. Sikesمشاهده پروفایل

دانشیار

• Biomolecular Engineering
• Clinical Diagnostics
• Redox Biology
• +۳ مورد دیگر

Hadley D. Sikes is an Associate Professor of Chemical Engineering at MIT, holding the Esther and Harold E. Edgerton Career Development Professorship. She leads the Sikes Lab, focusing on biomolecular engineering, redox biology, and clinical diagnostics. Her research develops innovative diagnostic tools and explores H₂O₂ signaling in cancer therapies. Sikes joined MIT in 2009 after postdoctoral work at the University of Colorado and Caltech. She earned a Ph.D. in Physical Chemistry from Stanford University (2003) and a B.S. from Tulane University (1997). Education: Ph.D., Stanford University, Physical Chemistry (2003) B.S., Tulane University, Chemistry (1997) Research Interests: Her lab investigates epigenetic modifications, redox-directed cancer therapies, and diagnostic technologies. Key projects include improving medical diagnostics for diseases like malaria and cancer, and developing paper-based assays for rapid disease detection. She emphasizes ethical research practices, student well-being, and fostering an inclusive lab environment. Awards & Recognition: Willard Henry Dow Professorship of Chemical Engineering (2023) MIT Committed to Caring (C2C) Award (2019) ACS Best of BIOT Award (2018) NAE Innovative Young Engineer (2017) Grants & Advising: Sikes mentors students holistically, prioritizing mental health and work-life balance. Her lab has pioneered methods to reduce student isolation and improve lab dynamics. She actively advises on career development, balancing academic rigor with personal growth. Labs & Teams: The Sikes Lab is part of MIT’s Chemical Engineering Department, collaborating with institutions globally on projects like SARS-CoV-2 antibody testing and cancer metabolism studies. Their work bridges fundamental research with clinical applications.

Andrea Gomezمشاهده پروفایل

استادیار

• Neuroscience
• Cell Biology
• Genetics
• +۴ مورد دیگر

Andrea Gomez is an Assistant Professor of Cell Biology, leading the Gomez Lab focused on understanding molecular mechanisms shaping neural circuits. Her research integrates electrophysiology, imaging, and molecular biology to study synaptic properties and their roles in psychiatric disorders such as autism and neurodegeneration. Current projects include investigating alternative RNA splicing's role in neural complexity, synaptic organization in hippocampal neurons, and the RNA biology of psychedelics. The lab explores how transsynaptic signaling and splicing regulators influence cell-type specific dynamics in neural networks. Notable contributions include discoveries on neurexin molecular codes, Lrp4's role in synapse formation, and the impact of psychedelic compounds on transcriptomic plasticity. Her work bridges fundamental neuroscience with translational insights into cognitive flexibility and neural repair.

Anna Panchenkoمشاهده پروفایل

استاد

• Computational Biology
• Biophysics
• Bioinformatics
• +۷ مورد دیگر

Dr. Anna Panchenko is a Professor at Queen's University, holding appointments in the Department of Pathology and Molecular Medicine (School of Medicine, Faculty of Health Sciences) and the School of Computing (Faculty of Arts and Science). She is also a Senior Investigator at the Ontario Institute for Cancer Research (OICR) and holds a Tier I Canada Research Chair in Computational Biology and Biophysics. Her research focuses on understanding cancer progression mechanisms, particularly how genetic and epigenetic factors influence mutations and their effects on proteins, interactions, and chromatin dynamics. She employs computational methods, including machine learning and molecular dynamics simulations, to study nucleosome positioning, histone interactions, and mutagenesis processes. Education: PhD in Biophysics (Lomonosov Moscow State University, 1993), BSc in Biophysics (Lomonosov Moscow State University, 1989). Research Interests: Computational biology, epigenetics, cancer genomics, molecular modeling, and machine learning applications in biomedicine. Her work integrates hypothesis-driven and data-driven approaches to uncover molecular mechanisms underlying cancer development. Notable Awards: Tier I Canada Research Chair in Computational Biology and Biophysics. Collaborations: Cross-disciplinary collaborations with OICR, Vector Institute for AI, and Queen's Cancer Research Institute. Tools developed include HYDROID for footprinting analysis and MutaBind for predicting mutation impacts on protein interactions. Labs: Computational Biology and Biophysics Lab at Queen's University, focusing on cancer driver mutations and epigenetic mechanisms.

Ana Oliveiraمشاهده پروفایل

استاد

• Molecular Neuroscience
• Neuroplasticity
• Epigenetic Regulation
• +۳ مورد دیگر

Ana Oliveira is a Heisenberg Professor of Molecular and Cellular Cognition Research at the Central Institute of Mental Health (CIMH) within Heidelberg University's Medical Faculty Mannheim. Her laboratory investigates molecular mechanisms underlying memory formation, neuroplasticity, and their dysfunctions in psychiatric disorders and aging. Her work emphasizes interdisciplinary approaches combining behavioral testing, epigenetic analysis, and electrophysiological methods. Key research focuses include transcriptional/epigenetic regulation of long-term adaptations, neuroplasticity responses to adverse environmental factors, and therapeutic strategies targeting these processes. Current DFG-funded projects (since 2021/2023) address molecular mechanisms of memory persistence, epigenetic control of cortical memories, and cognitive deficits in Tatton-Brown-Rahman syndrome models. The Oliveira Lab collaborates with the Interdisciplinary Center for Neurosciences (IZN) and employs cutting-edge tools like engram reactivation and chemogenetics. Her research bridges basic molecular mechanisms with translational neurobiology, aiming to uncover therapeutic targets for cognitive disorders.

• Epigenetics
• Cancer Biology
• Chromatin Modifications
• +۵ مورد دیگر

Dr. Yali Dou is a Professor of Medicine and Cancer Biology at the University of Southern California (USC) , holding the Marion and Harry Keiper Chair in Cancer Research . She co-directs the Ph.D. Program in Molecular Medicine and the USC Norris Brown Center for Cancer Drug Development , focusing on epigenetic mechanisms in cancer and development. Research Interests Epigenetic regulation of cell fate Chromatin modifications and gene networks MLL/KMT2 methyltransferases in leukemia Metabolic-genomic interplay Her work explores how histone methyltransferases like MLL1/3 contribute to oncogenic transformation and developmental disorders, with recent studies on nucleoprotein organization, metabolic heterogeneity, and kidney organoid modeling. Key Scientific Awards AAAS Fellow (2025) Leukemia & Lymphoma Society Scholar Award (2012) Stand Up to Cancer IRG Award (2011) AACR Gertrude B. Elion Award (2010) Dean’s Award in Basic Science, University of Michigan (2014) Dr. Dou’s lab investigates chromatin-based therapies for cancer and regenerative medicine, publishing extensively on MLL complexes, MOF acetyltransferase, and epigenetic-metabolic crosstalk.

• Ovarian Cancer Biology
• BRCA Mutations
• Molecular Diagnostics
• +۳ مورد دیگر

Louis Dubeau, MD, PhD is a Professor of Pathology at the Keck School of Medicine, University of Southern California, where he directs the Molecular Diagnostics Laboratory at the USC/Norris Comprehensive Cancer Center. A native of Canada, he joined USC as a post-doctoral fellow and has since established himself as a leading researcher in ovarian cancer biology and molecular diagnostics. Dr. Dubeau's research spans ovarian cancer genetics , BRCA mutation mechanisms , endoplasmic reticulum stress pathways , and environmental health impacts such as air pollution effects. His work integrates molecular pathology with translational approaches to understand carcinogenesis and develop novel therapeutic strategies. Recent publications reveal a strong focus on viral pathogenesis (particularly SARS-CoV-2), epigenetic modifications in cancer prevention, and stress response proteins in tumor development. His laboratory has secured over $14 million in research funding, with publications spanning oncology, virology, and environmental health. Dr. Dubeau actively contributes to medical education through lectures across multiple continents and has mentored more than 50 students through PhD advisory roles and graduate training programs. As Director of the Molecular Diagnostics Laboratory, he oversees advanced diagnostic testing at both Keck Hospital of USC and USC Norris Cancer Hospital, bridging clinical practice with cutting-edge research in cancer genomics and molecular pathology.

• Mitochondrial Biology
• Neuroscience
• Cancer Biology
• +۷ مورد دیگر

Brooke Erika Hjelm is an Assistant Professor of Clinical Cancer Biology at the University of Southern California. She holds the role of Culture and Engagement Champion, contributing to academic and institutional culture. Her research focuses on mitochondrial biology, psychiatric disorders, neurodegenerative diseases, and molecular mechanisms in cancer and autoimmune conditions. She has published extensively on topics such as mitochondrial DNA deletions, synaptic pathology in Alzheimer’s, and biomarker discovery for conditions like Sjögren’s syndrome and schizophrenia. Her work integrates cutting-edge technologies like single-cell RNA sequencing and iPSC-derived models to study disease mechanisms. Key areas of investigation include the role of mitochondrial dysfunction in schizophrenia and bipolar disorder, genetic mutations in congenital heart defects, and the development of diagnostic biomarkers using miRNA profiling. She has contributed to translational initiatives such as the Foundational Data Initiative for Parkinson’s Disease, bridging genetic maps with clinical mechanisms. No scientific awards are explicitly listed in the provided text. While no student advisees are mentioned, her research collaborations span interdisciplinary teams addressing complex biological systems. Her work emphasizes the interplay between genetic, molecular, and environmental factors in disease pathogenesis.

Zhaoyu Liمشاهده پروفایل

مدرس ارشد

• Cancer Prevention
• Quantitative Epigenomics
• Bioinformatics
• +۵ مورد دیگر

Dr. Zhaoyu Li is the Head of the Cancer Research Cluster at the School of Biomedical Sciences, University of Western Australia (UWA). He holds the Jack Tiddy Senior Lecturer position and is affiliated with the UWA Centre for Applied Bioinformatics and UWA Data Institute. His research focuses on cancer prevention through three main avenues: developing breast cancer prevention strategies, leveraging sex disparities in liver and esophageal cancers for prevention, and creating quantitative epigenomic tools like NUCLIZE for high-resolution histone modification analysis. Dr. Li has expertise in functional genomics, epigenomics, and bioinformatics, with a track record in NIH-funded projects including the Roadmap Epigenomics initiative. Education: PhD in Biochemistry from the University of Alberta (2006), M.S. and B.S. in Biochemistry from Dalian Medical University. His training includes postdoctoral work at the University of Pennsylvania and Mayo Clinic. Research interests emphasize translational oncology, epigenetic regulation in cancer, and computational biology applications. His lab actively recruits students and researchers in genomics, bioinformatics, and machine learning. Awards: K99/R00 Award, NIH R01 Grant (PI) Key Tools: NUCLIZE (quantitative epigenomic analysis)

Joseph C. Reeseمشاهده پروفایل

استاد

• Biochemistry
• Molecular Biology
• Gene Regulation
• +۶ مورد دیگر

Joseph C. Reese is a Professor of Biochemistry and Molecular Biology at Pennsylvania State University. His research focuses on gene regulation mechanisms, particularly the roles of the Ccr4-Not complex in transcription elongation, DNA damage response, and mRNA decay. He leads the Center for Eukaryotic Gene Regulation and has contributed to understanding stress-induced gene expression pathways. Education: B.A. in Biology from Boston University, Ph.D. in Molecular Physiology from University of Illinois Urbana-Champaign, and postdoctoral training at UMass Medical School under Michael Green. He joined Penn State in 1997. Research interests include the Ccr4-Not complex's roles in coordinating transcription, mRNA decay, and proteasomal degradation. His work uses yeast and mammalian systems to study how these pathways respond to stress and maintain genomic integrity. Awards: AAAS Fellow (2015), Howard B. Palmer Mentoring Award, American Heart Association Established Investigator. Funding: NIH grants R35 GM136353 (Ccr4-Not complex studies) and T32 GM125592 (Eukaryotic Gene Regulation Training). Lab activities include investigating Ccr4-Not's role in ubiquitylation of RNA Polymerase II, retrotransposon silencing in humans, and CRISPR-based functional genomics. His team employs multi-omics approaches and biochemical methods for protein complex analysis.

Samantha Nollمشاهده پروفایل

دانشیار

• Food Justice
• Environmental Ethics
• Agricultural Ethics
• +۴ مورد دیگر

Dr. Samantha Noll serves as Associate Professor and Associate Director at Washington State University's School of Politics, Philosophy, and Public Affairs. An environmental philosopher and public scholar, she champions just and sustainable food systems through interdisciplinary research that connects ethical theory with agricultural practice and policy. Her research program focuses on: Food justice and ethical consumption frameworks Environmental and agricultural ethics Climate change adaptation in food systems Gender equity in global agriculture Ethics of emerging food technologies (GMOs, CRISPR) Urban environmental justice initiatives Noll's recent scholarship (2021-2025) reveals consistent engagement with ethical dilemmas at the food-climate-technology nexus. She analyzes motivational barriers to climate action, develops urban justice frameworks, and critiques technological interventions in agriculture. Her book "Ethical Omnivores" introduces a practical philosophy for conscientious eating that addresses environmental, social, and health dimensions. Scientific recognition: No awards or fellowships were documented in the source materials. Professional activities: Student advising: No graduate students or postdocs were listed. Research grants: No funding sources were specified. Noll's institutional work centers on WSU's School of Politics, Philosophy, and Public Affairs, where she leads initiatives connecting philosophical inquiry to food system transformation. She extends her impact through public scholarship including the "Food for Thought" newsletter and media engagements.

Karim-Jean Armacheمشاهده پروفایل

استاد

• Epigenetics
• Gene Regulation
• Transcription
• +۳ مورد دیگر

Karim-Jean Armache is the Laura and Isaac Perlmutter Professor of Biochemistry in the Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine, part of NYU Langone Health. His research focuses on chromatin-modifying complexes like Polycomb Group (PcG), Trithorax Group (TrxG), and DNA methylation machinery, investigating their roles in gene regulation and their links to cancer and developmental disorders. Education: PhD from Ludwig Maximilian University Munich. His work spans epigenetics, chromatin structure, and cancer biology. Recent publications highlight mechanisms of histone modification, Polycomb complex activities, and cancer-associated epigenetic dysregulation. Received the Packard Foundation Fellow award. Led studies on chromatin dynamics and epigenetic regulation in disease contexts. Lab: Armache Lab focuses on molecular mechanisms of chromatin regulation, with ongoing projects on Polycomb complexes and cancer epigenetics. Collaborations include structural biology and biochemical approaches to probe chromatin states.

• Lipidomics
• Liver Disease
• Cancer Biology
• +۵ مورد دیگر

Jaya Prakash Golla is an Associate Research Scientist in Endocrinology at Yale School of Medicine, affiliated with the Diabetes Research Center. His research focuses on lipid metabolism, alcohol-induced pathologies, and cancer mechanisms. He holds a postdoctoral fellowship from the National Cancer Institute, NIH (2016). Research interests include investigating lipidomics in liver disease, alcohol-induced colorectal carcinogenesis, DNA damage responses, and metabolic disorders. His work spans systems biology approaches, mouse models, and omics profiling to understand disease mechanisms. Key publications explore lysophosphatidic acid’s role in inflammation, early-stage alcohol liver damage, and colorectal cancer pathways. He collaborates with experts in metabolomics, oncology, and toxicology. His studies often integrate multi-omics data and genetic engineering to uncover therapeutic targets in metabolic and cancer-related conditions.

• Epigenomics
• Genomics
• Inflammation
• +۶ مورد دیگر

Don X. Nguyen is a tenured Associate Professor at the Yale School of Medicine , holding joint appointments in the Department of Pathology and Medical Oncology and Hematology . He co-leads the Cancer Signaling Networks program at the Yale Cancer Center and directs the Nguyen Laboratory , specializing in CNS metastasis biology and epigenetic regulation of tumor progression. PhD in Microbiology & Immunology (University of Rochester, 2004) Postdoctoral Fellowship at Memorial Sloan Kettering Institute (2009) His research focuses on epigenetic regulation in tumor progression, particularly examining cell lineage control , cell-cell communication in disseminated tumor cells, and mechanisms linking drug resistance to brain metastasis . The lab develops novel metastasis models with expertise in central nervous system metastasis biology. Recent publications highlight his work on epigenetic drivers of metastasis (2025), immune landscape profiling in radiation necrosis (2024-2025), and drug resistance mechanisms in EGFR-mutant lung cancer (2024). His team collaborates with clinical researchers like Veronica Chiang and Katerina Politi on translational projects. Scientific honors include: Stewart Trust Scholar (2013) IASLC Young Investigator Award (2012) Yale Center for Clinical Investigation Scholar (2011) Class of 1961 Cancer Research Award (2021) The lab maintains affiliations with the Yale Stem Cell Center , Program in Translational Biomedicine , and SPORE in Lung Cancer initiatives.

Sean Limesandمشاهده پروفایل

استاد

• Fetal Development
• Endocrinology
• Animal Physiology
• +۳ مورد دیگر

Sean Limesand, PhD is a Professor at the University of Arizona's School of Animal Sciences & Comparative Biomedical Sciences. His research focuses on fetal development, endocrine adaptations, and metabolic programming in animal models, particularly sheep and goats. Key areas include fetal growth restriction (FGR), placental insufficiency, and the long-term impacts of in utero stressors like hypoxia, heat, and maternal infections. His work integrates molecular biology (e.g., transcriptomics), cellular physiology (e.g., β-cell function), and whole-animal studies. Notable contributions include identifying dysregulated pathways in growth-restricted fetal tissues, characterizing mitochondrial adaptations in FGR, and exploring therapeutic interventions (e.g., oxygen/glucose therapy in ovine models). Research also addresses environmental challenges like maternal heat stress and its effects on lactation/placental function, as well as SARS-CoV-2's impact on maternal-neonatal outcomes. His studies often involve interdisciplinary approaches, combining omics technologies with physiological measurements to understand developmental origins of health and disease. Current studies investigate single-cell transcriptomics of SS-cells in FGR, epigenetic modifications in thermotolerant ewes, and molecular mechanisms linking fetal programming to adult metabolic disorders. These efforts aim to translate findings into clinical strategies for managing growth-restricted infants and improving livestock resilience.

Constance Alabertمشاهده پروفایل

مدرس ارشد

• Molecular Biology
• Epigenetics
• Cancer Research
• +۳ مورد دیگر

Dr. Constance Alabert is a Senior Lecturer and Principal Investigator at the School of Life Sciences, University of Dundee, in the Department of Molecular Cell and Developmental Biology. Her research focuses on understanding the mechanisms of epigenetic information restoration on newly replicated DNA during cell division, particularly its implications in cancer. She employs the Nascent Chromatin Capture (NCC) technology to study chromatin dynamics and identify key players in epigenetic maintenance. Roles: Senior Lecturer, Principal Investigator Affiliations: University of Dundee, School of Life Sciences Research Interests: Alabert’s work investigates how cells re-establish epigenetic 'tags' after DNA replication, aiming to uncover links between epigenetic disruption and diseases like cancer. Her lab uses advanced proteomic and genomic approaches, including NCC, to dissect chromatin assembly and repair mechanisms. Publications highlight studies on histone propagation, DNA repair complexes (e.g., TONSL-MMS22L), and replication fork regulation. Her work bridges basic cell biology with translational cancer research. Awards: ERC Early Career Grant (2017), Cancer Research UK Fellowship (2016) Grants: Funded by EU and UK agencies for projects on chromatin replication and cancer. Advising and Mentorship: Alabert supervises PhD students and contributes to academic committees, emphasizing training in molecular and cellular biology. Labs/Teams: Leads a research group focused on chromatin dynamics, collaborating with international teams on proteomics and epigenetics.