Joseph C. Reese

Joseph C. Reese is a Professor of Biochemistry and Molecular Biology at Pennsylvania State University. His research focuses on gene regulation mechanisms, particularly the roles of the Ccr4-Not complex in transcription elongation, DNA damage response, and mRNA decay. He leads the Center for Eukaryotic Gene Regulation and has contributed to understanding stress-induced gene expression pathways.

Education: B.A. in Biology from Boston University, Ph.D. in Molecular Physiology from University of Illinois Urbana-Champaign, and postdoctoral training at UMass Medical School under Michael Green. He joined Penn State in 1997.

Research interests include the Ccr4-Not complex's roles in coordinating transcription, mRNA decay, and proteasomal degradation. His work uses yeast and mammalian systems to study how these pathways respond to stress and maintain genomic integrity.

• Awards: AAAS Fellow (2015), Howard B. Palmer Mentoring Award, American Heart Association Established Investigator.
• Funding: NIH grants R35 GM136353 (Ccr4-Not complex studies) and T32 GM125592 (Eukaryotic Gene Regulation Training).

Lab activities include investigating Ccr4-Not's role in ubiquitylation of RNA Polymerase II, retrotransposon silencing in humans, and CRISPR-based functional genomics. His team employs multi-omics approaches and biochemical methods for protein complex analysis.