Shardul Kulkarni

Shardul Kulkarni is an Assistant Research Professor in the Department of Biochemistry and Molecular Biology at Pennsylvania State University, affiliated with the Center for Eukaryotic Gene Regulation (CEGR). He holds a Ph.D. in Biotechnology (2013) from the University of Pune, India, and completed postdoctoral research at the National Institutes of Health (NIH), USA, under Dr. Jon Lorsch. His research focuses on gene expression regulation mechanisms, particularly translational control in eukaryotes and the functional roles of the CCR4-NOT complex.

Education:

• Ph.D. in Biotechnology, University of Pune, India (2013)
• M.Sc. in Zoology, India (2007)
• B.Sc. in Microbiology, India (2005)

Research Interests:

Dr. Kulkarni’s work spans RNA biology, translational regulation, and genome-wide analysis of translation mechanisms. He investigates how environmental stimuli (e.g., stress, temperature) influence gene expression at the translational level, with a focus on upstream open reading frames (uORFs) and the CCR4-NOT complex. His recent studies explore the global regulatory roles of CCR4-NOT in silencing retrotransposons and maintaining genome integrity.

Publications Overview:

His publications highlight contributions to understanding insulin mRNA regulation, suboptimal translation initiation, and the role of eIF1A in cancer. Recent work includes discoveries on CCR4-NOT’s impact on retrotransposon activity and DNA damage responses, advancing knowledge in translational control and gene expression.

Labs/Teams:

He collaborates within Dr. Joseph Reese’s lab at PSU and contributes to the BMMB Graduate Program. His editorial role at Publons further demonstrates his engagement with scientific communication.