Ana Tufegdžić Vidaković

Ana Tufegdžić Vidaković is a Researcher at the University of Cambridge's Medical Research Council Laboratory of Molecular Biology (MRC-LMB). Her research focuses on the molecular basis of gene transcription, particularly how RNA polymerase II navigates DNA damage and cellular stress challenges. She employs genome-wide, biochemical, and cell biology approaches in mammalian systems to study transcriptional regulation during homeostasis and stress conditions.

Key research areas include DNA damage-induced transcriptional shutdown, RNA polymerase II post-translational modifications, and proteasomal degradation pathways. Her work reveals how cells distinguish stalled transcription complexes to initiate specific repair mechanisms while preventing global transcriptional collapse. The lab investigates parallels between DNA damage responses and other stress-induced transcriptional changes.

Her research group includes:

• Pegah Abyaneh
• Yu Bao
• Roberta Cacioppo
• Benjamin Haworth
• Pei Qin (Sabrina) Ng
• Iván Shlamovitz

Recent publications highlight her contributions to understanding RNA Pol II regulation through:

• CRL3ARMC5 ubiquitin ligase mechanisms
• Integrator phosphatase functions
• Proteasomal degradation pathways

These works appear in top-tier journals like Molecular Cell and Cell.