جست‌وجوی استاد و پژوهشگر

• Virology
• Cell Biology
• Molecular Biology
• +۴ مورد دیگر

Kashif Mehmood is a Research Fellow in the Genetics Department at Yale School of Medicine, Yale University. His research focuses on virology, cell biology, and molecular mechanisms of viral entry and host-pathogen interactions. He investigates JC polyomavirus entry dynamics mediated by serotonin receptors, influenza hemagglutinin interactions with membrane lipids, and retromer-mediated transport pathways. Additionally, he explores microbial production of keratinase for sustainable waste management. His work bridges virology, neuroscience, and biotechnology, with implications for understanding viral pathogenesis and developing eco-friendly enzymatic solutions. Research interests include viral trafficking mechanisms, receptor-ligand interactions, lipid signaling, and industrial enzyme applications. Notable contributions address JC polyomavirus entry via serotonin receptors, influenza virus membrane fusion dynamics, and Bacillus velezensis-derived keratinase for keratin waste degradation.

Derek Wilsonمشاهده پروفایل

استاد

• Protein Dynamics
• Microfluidics
• Time-resolved Mass Spectrometry
• +۷ مورد دیگر

Derek Wilson is a Full Professor in the Department of Chemistry at York University, holding the York Research Chair (Tier 2). His research focuses on protein dynamics and structural biology using advanced mass spectrometry techniques, including time-resolved electrospray ionization (TRESI) and hydrogen-deuterium exchange (HDX-MS). He leads the Wilson Lab, which investigates protein motions, enzyme mechanisms, and interactions with ligands, membranes, and other proteins. His expertise spans analytical and biological chemistry, with a strong emphasis on developing microfluidics-based tools for studying millisecond-to-second timescale processes. Key projects include elucidating the dynamics of antibiotic resistance enzymes (e.g., β-lactamases), intrinsically disordered proteins (e.g., tau in Alzheimer’s), and antiapoptotic proteins (Bcl-2/Mcl-1) involved in cancer. Education: Ph.D. in Chemistry (specific details not listed in text). Awards include the Tier 2 York Research Chair. The lab collaborates widely with institutions like the University of Chicago and St. Jude Children’s Hospital, advancing drug discovery and structural biology. Current students and alumni include researchers studying STAT5b oncogenic mutations, tau protein dynamics, and nanodisc technologies. The lab operates cutting-edge equipment such as the Synapt G2-S HDMS and VersaLaser microfluidic devices.

• Cancer Metabolism
• Signal Transduction
• Cancer
• +۳ مورد دیگر

Zhimin Lu is a Professor and Dean of the Institute of Translational Medicine at Zhejiang University, China, and holds the Kuancheng Wang Distinguished Chair. Previously, he served at The University of Texas MD Anderson Cancer Center for 18 years as a Professor and Director of the Cancer Metabolism Program. Education : MD from Taishan Medical College, PhD from City University of New York, and postdoctoral training at The Salk Institute. His research focuses on cancer metabolism , signal transduction , and molecular mechanisms of tumor progression . He pioneered discoveries on the non-metabolic roles of metabolic enzymes in cancer, including the protein kinase activity of PKM2, Warburg effect mechanisms, and histone modifications driven by metabolic enzymes. His publications (over 120 peer-reviewed articles, including 40+ in Cell, Nature, and Science sister journals) reveal trends in oncogenic signaling, metabolic reprogramming, and epigenetic regulation. Key subfields include PKM2 dynamics, Warburg effect, tumor microenvironment, and metabolic-epigenetic crosstalk. Scientific Awards : Fellow of AAAS (2017), Dallas/Fort Worth Living Legend Award (2016), James S. McDonnell Foundation Scholar (2012), American Cancer Society Research Scholar (2009), and multiple MD Anderson awards. He serves as Chief Editor for Metabolic Discovery and Visualized Cancer Medicine , Deputy Editor for the Journal of The National Cancer Center , and editorial board member for over 10 journals. His work has transformed understanding of cancer metabolism and its diagnostic/therapeutic applications.

Dianne K. Newmanمشاهده پروفایل

استاد

• Bioenergetics
• Microbial Metabolism
• Geobiology
• +۵ مورد دیگر

Dianne K. Newman is the Gordon M. Binder/Amgen Professor of Biology and Geobiology and Merkin Institute Professor at the California Institute of Technology (Caltech). She joined Caltech in 2000 as a Clare Booth Luce Assistant Professor, advancing to Associate Professor (2005), Professor (2006), and endowed professorship roles. She served as Executive Officer for Biology and Biological Engineering (2017–2023) and was an HHMI Investigator (2005–2016). Education: B.A., Stanford University (1993) Ph.D., Massachusetts Institute of Technology (1997) Her research explores microbial bioenergetics and electron transfer in oxygen-free environments, focusing on redox-active metabolites (e.g., phenazines) and biofilm survival strategies in chronic infections (e.g., Pseudomonas aeruginosa in wounds) and agricultural rhizospheres. The Newman Lab integrates genetics, electrochemistry, and advanced microscopy to study bacterial physiology at single-cell and community levels. Recent publications (2023–2025) predominantly investigate microbial metabolism under stress, biofilm dynamics, and applications in health/environment. Key trends include antibiotic tolerance mechanisms, electrochemical methods for metabolic analysis, and translational work on chronic wound treatments. Awards and Honors: Clare Booth Luce Assistant Professor (2000–2005) HHMI Investigator (2005–2016) Gordon M. Binder/Amgen Professor (2016–present) Davis Leadership Chair (2017–2020) Merkin Institute Professor (2024–present) She leads the interdisciplinary Newman Lab, training researchers in microbial physiology. Her work is supported by HHMI and institutional grants, with collaborations across Caltech's Center for Environmental Microbial Interactions (CEMI) and Resnick Sustainability Institute. Future directions emphasize translating microbial survival mechanisms into health and sustainability solutions.

• Structural Biology
• Bacterial Enzymology
• Neuroscience
• +۳ مورد دیگر

Sudhanshu Gautam is a Research Fellow at the Department of Cell Biology , Yale School of Medicine , focusing on molecular mechanisms of cellular processes. His work bridges structural biology, bacterial enzymology, and neuroscience. Education: PhD, Indian Institute of Science (2022), Molecular Biophysics Unit Integrated BSc-MSc, National Institute of Science Education and Research (2015) Research Interests include structural analysis of proteins involved in synaptic vesicle exocytosis, bacterial DNA repair enzymes, and transcriptional regulation. His expertise spans: Cryo-electron tomography and tethered giant unilamellar vesicles Mycobacterial cyclic-di-AMP homeostasis RNA polymerase functional dynamics Phosphatidate phosphatase roles in cellular respiration Publication Trends highlight investigations into: Cyclic Di-AMP synthase/hydrolase systems in Mycobacterium smegmatis Antibiotic discovery targeting RNA polymerase Protein structure-function relationships across bacterial and eukaryotic systems Lipid metabolism in Tetrahymena and yeast Laboratory Affiliation: Rothman Lab, Yale School of Medicine, specializing in cellular and molecular neuroscience research.

Wim van der Puttenمشاهده پروفایل

استاد

• Climate Change
• Land Use Change
• Biological Invasions
• +۵ مورد دیگر

Wim van der Putten is a Professor in Functional Biodiversity at Wageningen University & Research and Head of the Department of Terrestrial Ecology at the Netherlands Institute of Ecology (NIOO-KNAW). He holds an honorary professorship at the Chinese Academy of Agricultural Sciences. His research focuses on climate change, land use dynamics, and soil biodiversity. He graduated from Wageningen University in 1984 and completed his PhD in 1989 on coastal dune ecosystems. He has led major projects like the Global Soil Biodiversity Initiative and the EU-funded EcoFinders and Liberation programs. His work bridges fundamental research with practical applications, such as soil health monitoring and ecosystem restoration. Key achievements include ERC and VICI grants, co-authoring the European and Global Soil Biodiversity Atlases, and chairing initiatives like the Heineken Environment Prize. His recent studies explore soil microbial communities, organic farming transitions, and biodiversity responses to global changes. He emphasizes sustainable land management, advocating for 'productive deintensification' in agriculture.

Gwion Williamsمشاهده پروفایل

پژوهشگر

• Environmental Microbiology
• Biotechnology
• Plastic Degradation
• +۳ مورد دیگر

Gwion Williams is a Researcher at Bangor University's School of Environmental and Natural Sciences. He holds a PhD (2018) in Advanced Biological Sciences, an MSc (2018) in Functional & Comparative Genomics, and a BSc (2014) in Biological Sciences and Philosophy. His research focuses on microbial degradation of plastics, environmental biotechnology, and microbial ecology in extreme environments. He has contributed to studies on plastic pollution impacts, bioleaching optimization, and microbial communities in polluted ecosystems. Key projects include discovering plastic-degrading enzymes via metagenomic screening and engineering their efficacy, investigating microplastic effects on crop systems, and analyzing microbial adaptations in wastewater-to-marine plastic transition zones. His work integrates field-based assessments with lab techniques to address environmental challenges. Williams collaborates with institutions like the Golyshin Lab and contributes to interdisciplinary projects on bioremediation and sustainable resource management. His expertise spans enzyme engineering, microbial diversity analysis, and environmental microbiology applications.

Bin Chenمشاهده پروفایل

استاد پژوهشی

• Photodynamic Therapy
• Cancer Biology
• Porphyrin Metabolism
• +۳ مورد دیگر

Bin Chen is the McNeil Research Professor and Director of the Graduate Program in Pharmacology/Toxicology in the Department of Pharmaceutical Sciences. His research focuses on photodynamic therapy (PDT) mechanisms, tumor porphyrin metabolism, and enhancing PDT efficacy through molecular targeting. He holds a PhD from the University of Leuven, Belgium, and has contributed to over a dozen influential studies in cancer therapy and PDT. Education: Bachelor of Science (BS), Nanjing University of Chinese Medicine Master of Science (MS), Nanjing University of Chinese Medicine Doctor of Philosophy (PhD), University of Leuven, Belgium Research Interests: Mechanisms of anticancer agents, particularly photosensitizing agents. Photodynamic therapy (PDT) enhancement via molecular pathways like PI3K and ABCG2 transporters. Role of porphyrin metabolism (e.g., protoporphyrin IX) in tumor detection and treatment. Fluorescence-guided resection and PDT applications in oncology. Article Trends: Focus on ALA-mediated protoporphyrin IX fluorescence and PDT efficacy. Investigation of ABCG2 transporters, PI3K signaling, and enzyme deficiencies affecting PDT response. Analysis of vascular vs. tumor cell responses to PDT agents like verteporfin. Awards and Grants: No awards or grants explicitly mentioned in the text. Advising and Labs: Leads a research lab focusing on PDT mechanisms and tumor metabolism. Advises students in pharmacology/toxicology programs but no explicit student names are listed.

Shoib Siddiquiمشاهده پروفایل

مدرس ارشد

• Cancer Biology
• Immunology
• Glycobiology
• +۴ مورد دیگر

Dr. Shoib Siddiqui is a Senior Lecturer at the University of Hertfordshire's School of Life and Medical Sciences, specializing in cancer biology, immunology, and glycobiology. Previously, he held positions at the American University of Ras Al Khaimah and conducted postdoctoral research at UC San Diego under Prof. Ajit Varki. His research focuses on sialic acids, Siglecs, and microRNA mechanisms in cancer, Alzheimer’s, and sepsis. He earned his Ph.D. from ETH Zurich, investigating neuropilin-2 in skin cancer progression. Education: Ph.D. in Vascular Biology, Immunology, and Cancer Biology (ETH Zurich, 2009–2013) M.Sc. in Biotechnology (IIT Bombay, 2008) Research Focus: Dr. Siddiqui’s work explores cancer progression pathways, tumor biomarkers, and novel therapies. Key areas include Siglec-sialoglycan interactions, microRNA targeting, and drug repurposing for colorectal cancer. His recent projects involve developing RNAi therapeutics and inhibitors for Siglec-15. Projects: Fluralaner as a Colorectal Cancer Therapeutic (2026–2027) ADAMTS-7 Inhibition for Coronary Artery Disease (2022) UK-China Mycotoxin Reduction Alliance (2022–2023) Publications: Over 39 peer-reviewed articles in journals like Journal of Clinical Investigation , PNAS , and Blood , with a focus on oncology, glycobiology, and immunology. Recent trends emphasize Siglec-targeted therapies, microRNA networks, and drug repurposing strategies. Awards: No formal awards listed, but noted for impactful publications in high-impact journals. Advising & Grants: Served as Principal Investigator (PI) on RNAi therapeutics and Co-Investigator (CoI) on Siglec-15 and ADAMTS-7 projects. Collaborations span international institutions and cross-disciplinary teams. Labs/Teams: Active in the Biosciences Research Group and Centre for Research in Mechanisms of Disease and Drug Discovery at UH. Collaborates with global researchers in glycobiology and oncology.

Hege Christensenمشاهده پروفایل

استاد

• Pharmacokinetics
• Drug metabolism
• Drug transport
• +۳ مورد دیگر

Hege Christensen is a Professor of Pharmacology at the University of Oslo's Department of Pharmaceutical Biosciences. She has been affiliated with the Department since 1992 and holds leadership roles in academic programs such as the Master's Degree in Pharmacy and Clinical Pharmacy. Her research focuses on pharmacokinetics, particularly drug metabolism variability due to genetic and environmental factors, and drug interactions. She collaborates with institutions like the IMUP Center for Immunopharmacology in Transplantation and the School of Pharmacy at the University of Manchester. Key areas include physiology-based pharmacokinetic modeling and in vitro-in vivo extrapolation techniques. Christensen's education includes a Cand.pharm. from the University of Oslo (1986), a Dr.scient. (1992), and an Advanced Diploma in Clinical Pharmacy Teaching from the University of Leeds (1996). Her career spans roles at the International Heart Research Institute (1991–1992) and pharmaceutical industries like Løvens Kemiske Fabrik (1986–1987). Her research interests emphasize understanding drug bioavailability and optimizing therapies through pharmacokinetic studies. Recent work investigates gastric bypass surgery's effects on drug metabolism and the role of microbiome signatures in weight loss outcomes. She has published extensively in journals like Clinical Pharmacokinetics and Mucosal Immunology, with a focus on cytochrome P450 enzymes, drug transporters, and obesity-related pharmacology. Notable collaborations include projects with Professor Amin Rostami-Hodjegan at the University of Manchester, exploring advanced pharmacokinetic modeling. Her work bridges clinical and translational research, addressing challenges in drug dosing for patients with obesity and comorbidities.

• Plant Biotechnology
• Molecular Biology
• Biochemistry
• +۴ مورد دیگر

Dr. Alexandra Machado Ferreira Castilho is a leading researcher at the Institute of Plant Biotechnology and Cell Biology within the University of Natural Resources and Life Sciences, Vienna (BOKU) . She has served as Principal Investigator since 2018 and previously as Scientific Coordinator of the Laura Bassi Center PlantBioP (2010-2017). Her work focuses on Plant Molecular Farming and Glycoengineering , aiming to optimize plant-based production of therapeutically relevant glycoproteins. Specializes in tailoring N-glycan profiles for biopharmaceuticals Develops plant cell factories for antibody and decoy receptor production Key projects include SARS-CoV-2 neutralization strategies and cancer immunotherapy agents Her recent publications analyze glycoengineering techniques in Nicotiana benthamiana , covering topics like ACE2-Fc decoys for viral neutralization, PD1/PDL1 blockade for oncology, and protease suppression for protein stability. She has received funding from the Austrian Science Fund (FWF) for projects on immune checkpoint inhibitors and glycosylation pathway modulation.

• Biocatalysis
• Fungal Enzymes
• Bacterial and Algal Polymers
• +۲ مورد دیگر

Anna Jarosz-Wilkołazka , Professor of Biological Sciences at the Maria Curie-Skłodowska University (UMCS) in Lublin, is affiliated with the Faculty of Biology and Biotechnology and leads research at the Department of Biochemistry and Biotechnology . With expertise spanning fungal enzymes, microbial polymers, and biomaterial modification, her work bridges biochemistry, biotechnology, and environmental science. Current research focuses on biocatalysis in aqueous/non-aqueous systems , fungal enzyme applications (particularly laccases), and the characterization of extracellular polymeric substances (EPS) from bacteria and algae for biosorption and bioflocculation. She has coordinated major research projects including "Modification of biopolymer materials with protease inhibitors" (NCN OPUS 13, 2017-2022) and "Oxalate oxidase in Abortiporus biennis" (NCN Opus 5, 2015-2019). Her recent publications (2016-2023) highlight advancements in fungal laccase immobilization for pollutant removal, EPS applications for heavy metal biosorption, and novel bioactive dyes. A 2023 study investigated oxalate oxidase sources in wood-rotting fungi, while 2020 work explored EPS from endophytic Fusarium culmorum strains affecting cereal crops. Earlier studies focused on lignin degradation mechanisms (2017) and EPS-driven biomineralization (2016). As a scientific supervisor, she has guided NCN projects on Rhodococcus opacus EPS properties (2016-2021) and fungal enzyme immobilization techniques (2015-2018). She actively participates in science outreach through initiatives like the Mobile Science Festival and Design Thinking Week under Erasmus+.

• Peptide Chemistry
• Bioorganic Chemistry
• Enzyme Inhibition
• +۳ مورد دیگر

Dr. Agata Gitlin-Domagalska serves as an Adjunct Professor at the Faculty of Chemistry, University of Gdańsk, where she leads research in the Department of Molecular Biochemistry and Laboratory of Bioorganic Chemistry. Her work bridges peptide chemistry and bioorganic drug design, focusing on innovative synthetic strategies and therapeutic applications. Academic Affiliation: Faculty of Chemistry, University of Gdańsk Department: Department of Molecular Biochemistry Laboratory: Laboratory of Bioorganic Chemistry Specializing in peptide synthesis and prodrug development , Dr. Gitlin-Domagalska investigates strategies to enhance oral bioavailability of charged peptides through lipophilic charge masking and non-covalent inhibition of serine proteases like matriptase and furin . Her research extends to antimicrobial peptide conjugates with dual therapeutic functions and Zika virus suppression via protease inhibition. Recent publications highlight her expertise in peptide splicing mechanisms , solid-phase synthesis optimization , and nanoparticle-based delivery . She has developed cyclic RGD prodrugs for targeted intestinal permeability and bicyclic furin inhibitors using combinatorial chemistry approaches. Her work contributes to antibiotic conjugates with leukemia-selective antifungal activity , neuroprotective humanin analogs , and vasopressin derivatives with expanded therapeutic potential. Current trends emphasize matriptase-selective inhibitors and earthworm-derived antimicrobial nanoparticles . Dr. Gitlin-Domagalska employs model membrane biosensing for drug-membrane interaction studies and has pioneered high-shear mixing techniques to improve amide bond formation efficiency in peptide synthesis processes.

Alison E. Ringelمشاهده پروفایل

استادیار

• Immunology
• Cancer Biology
• Molecular Biology
• +۳ مورد دیگر

Alison E. Ringel is an Assistant Professor of Biology and Core Member at the Ragon Institute of MGH, MIT, and Harvard. Her research focuses on molecular mechanisms enabling immune cells to function under stress, particularly in tumor microenvironments and metabolic challenges. She holds a PhD from Johns Hopkins University School of Medicine (2015) and a BA from Wesleyan University (2009). Her research integrates CD8+ T cell biology Metabolic reprogramming Tumor-immune interactions Systemic metabolic influences Notable achievements include the 2021 Forbeck Scholar award. Recent work highlights obesity’s role in tumor immunity suppression and age-related T cell vulnerabilities. Her lab employs interdisciplinary approaches to uncover therapeutic vulnerabilities in immune cells within diseased states.

Achim Kramerمشاهده پروفایل

استاد

• Chronobiology
• Circadian Rhythms
• Molecular Biology
• +۳ مورد دیگر

Achim Kramer serves as Professor of Chronobiology (W2, tenured) at Charité - Universitätsmedizin Berlin, where he chairs the independent Research Unit for Chronobiology within the Institute of Medical Immunology. His academic career spans molecular chronobiology research and teaching since 2002, with significant contributions to understanding circadian clock mechanisms in mammals. His educational background includes a Biochemistry degree from Freie Universität Berlin (1988-1993), a Ph.D. in Biochemistry (summa cum laude, 1996) from Humboldt Universität zu Berlin, and piano training at Berlin's Hochschule der Künste (1990-1994). Postdoctoral work included research at Harvard Medical School (1999-2001) under Charles Weitz and positions at IRBM Rome and Charité. Dr. Kramer's research centers on molecular mechanisms of circadian clocks, with expertise in protein interactions (CRY1-PER2), post-translational modifications, peripheral tissue clocks (macrophages, skin), and translational applications like circadian blood biomarkers. His work bridges structural biology, immunology, and sleep medicine to address how biological timing affects health and disease. Analysis of his publications reveals consistent focus on circadian molecular machinery across diverse biological contexts, with increasing translational emphasis in recent years on diagnostic applications and tissue-specific clock functions. His structural work on cryptochromes and phosphorylation mechanisms underpins fundamental understanding of clock regulation. Key honors include the Heinz-Maier-Leibnitz Award (DFG, 2002), Brooks Fellowship (Harvard, 2001), multiple Teaching Awards for Medical Neurosciences (2010-2015), and a Young Researcher's Award from Charité (1998). He leads the Chronobiology Research Unit within Charité's Institute of Medical Immunology, participating in the SFB/TRR186 consortium on molecular switches. His service includes chairing the 2015 Gordon Research Conference on Chronobiology, editorial roles at PLoS Genetics and Journal of Biological Rhythms, and leadership positions in the Society for Research on Biological Rhythms and European Biological Rhythms Society.