Bin Chen

Bin Chen is the McNeil Research Professor and Director of the Graduate Program in Pharmacology/Toxicology in the Department of Pharmaceutical Sciences. His research focuses on photodynamic therapy (PDT) mechanisms, tumor porphyrin metabolism, and enhancing PDT efficacy through molecular targeting. He holds a PhD from the University of Leuven, Belgium, and has contributed to over a dozen influential studies in cancer therapy and PDT.

Education:

• Bachelor of Science (BS), Nanjing University of Chinese Medicine
• Master of Science (MS), Nanjing University of Chinese Medicine
• Doctor of Philosophy (PhD), University of Leuven, Belgium

Research Interests:

• Mechanisms of anticancer agents, particularly photosensitizing agents.
• Photodynamic therapy (PDT) enhancement via molecular pathways like PI3K and ABCG2 transporters.
• Role of porphyrin metabolism (e.g., protoporphyrin IX) in tumor detection and treatment.
• Fluorescence-guided resection and PDT applications in oncology.

Article Trends:

• Focus on ALA-mediated protoporphyrin IX fluorescence and PDT efficacy.
• Investigation of ABCG2 transporters, PI3K signaling, and enzyme deficiencies affecting PDT response.
• Analysis of vascular vs. tumor cell responses to PDT agents like verteporfin.

Awards and Grants:

No awards or grants explicitly mentioned in the text.

Advising and Labs:

Leads a research lab focusing on PDT mechanisms and tumor metabolism. Advises students in pharmacology/toxicology programs but no explicit student names are listed.