معرفی
Derek Wilson is a Full Professor in the Department of Chemistry at York University, holding the York Research Chair (Tier 2). His research focuses on protein dynamics and structural biology using advanced mass spectrometry techniques, including time-resolved electrospray ionization (TRESI) and hydrogen-deuterium exchange (HDX-MS). He leads the Wilson Lab, which investigates protein motions, enzyme mechanisms, and interactions with ligands, membranes, and other proteins.
His expertise spans analytical and biological chemistry, with a strong emphasis on developing microfluidics-based tools for studying millisecond-to-second timescale processes. Key projects include elucidating the dynamics of antibiotic resistance enzymes (e.g., β-lactamases), intrinsically disordered proteins (e.g., tau in Alzheimer’s), and antiapoptotic proteins (Bcl-2/Mcl-1) involved in cancer.
- Education: Ph.D. in Chemistry (specific details not listed in text).
Awards include the Tier 2 York Research Chair. The lab collaborates widely with institutions like the University of Chicago and St. Jude Children’s Hospital, advancing drug discovery and structural biology.
Current students and alumni include researchers studying STAT5b oncogenic mutations, tau protein dynamics, and nanodisc technologies. The lab operates cutting-edge equipment such as the Synapt G2-S HDMS and VersaLaser microfluidic devices.
