جست‌وجوی استاد و پژوهشگر

Bruce Stillmanمشاهده پروفایل

استاد

• DNA Replication
• Cell Cycle Regulation
• Chromatin Assembly
• +۴ مورد دیگر

Bruce Stillman is the President and Chief Executive Officer of Cold Spring Harbor Laboratory (CSHL), where he has held academic and leadership roles since 1979. He is also the Oliver R. Grace Professor in the Cancer Center and a Member of the Stillman Laboratory. With a B.S. from the University of Sydney and a Ph.D. from the Australian National University, his research focuses on DNA replication mechanisms, cell cycle regulation, and epigenetic inheritance in eukaryotes. His work identified key proteins like the Origin Recognition Complex (ORC), pivotal for replication initiation and centromere function. Stillman has received prestigious awards, including the Dr H.P. Heineken Prize and Gairdner International Award. He oversees CSHL’s research, education, and initiatives, such as its preprint server medRxiv, and advocates for scientific leadership and gender diversity in STEM. Research emphasizes ORC’s role in replication, checkpoint signaling (e.g., Rad53 kinase), and applications in cancer biology. Recent articles explore bacterial replication mechanisms, genome assembly (Yarrowia lipolytica), and structural studies of replication factors. Awards and honors include membership in the U.S. National Academy of Sciences, Royal Society, and multiple fellowships. Collaborative projects and mentorship highlight his commitment to advancing biomedical science and training future researchers.

Eric Van Nostrandمشاهده پروفایل

استادیار

• RNA Genomics Technologies
• RNA Processing Mechanisms
• Host:RNA Viral Interactions
• +۴ مورد دیگر

Eric Van Nostrand is an Assistant Professor in the Department of Biochemistry and Molecular Biology at Baylor College of Medicine, and a member of the Therapeutic Innovation Center. His research focuses on RNA processing regulatory networks, particularly how RNA binding proteins (RBPs) regulate RNA processing in health and disease. He holds a PhD from Stanford University School of Medicine (2012), a BS from MIT (2005), and completed a postdoctoral fellowship at UC San Diego (2020). Research interests include RNA genomics technologies, mechanisms of RNA processing, host-viral interactions, and bioinformatics. His group develops innovative methods like chimeric eCLIP to map RBP interactions and study their roles in viral replication, cancer, and physiological processes. Key projects investigate how viruses hijack host RNA processing systems, and how dysregulated mRNA translation drives breast cancer progression. Notable contributions include defining snoRNA-target interactions using chimeric eCLIP, uncovering roles for SNORD89 in spliceosome biogenesis, and identifying novel RBP functions in pluripotent stem cells. He is also involved in industry collaborations, serving as co-founder and advisor to Eclipse BioInnovations. Publications span high-impact journals like Nature, Genome Biology, and Cell Reports, with a focus on RNA biology, viral mechanisms, and translational applications. His work bridges computational and experimental approaches to advance understanding of RNA's role in disease and therapeutic development.

Daniel A Gorelickمشاهده پروفایل

دانشیار

• Cell signaling
• Environmental influence on organ formation & function
• Zebrafish genetics

Daniel A. Gorelick, Ph.D., is an Associate Professor at Baylor College of Medicine in the Department of Molecular & Cellular Biology. His research utilizes genetic tools in zebrafish to study how endogenous and environmental hormones influence the development and function of organs including the heart, brain, and gonad. Education: B.A. from University of Pennsylvania Ph.D. from Johns Hopkins University School of Medicine Postdoctoral Fellowships: AAAS Science & Technology Policy Fellowship (US Department of State) and Developmental Biology, Endocrinology (Carnegie Institution for Science) Research Focus: Dr. Gorelick's work bridges cell signaling, environmental influences on development, and zebrafish genetics. His team investigates hormone-mediated processes using CRISPR-based methods, receptor characterization, and high-throughput screening approaches to understand fundamental biological mechanisms and toxicological responses. Publication Trends: Recent articles focus on improving scientific peer review, zebrafish models for vaccine development and toxicology, estrogen receptor mechanisms, and novel screening platforms. This reflects dual emphases on research methodology innovation and molecular mechanisms of endocrine disruption. Funding: Actively supported by NIH/NIEHS and NIH/NICHD grants investigating aryl hydrocarbon receptor interactions and developmental toxicity mechanisms.

Nicolas Leon Youngمشاهده پروفایل

دانشیار

• Epigenetics
• Post-translational Modifications
• Chromatin Biology
• +۶ مورد دیگر

Nicolas Leon Young is an Associate Professor at Baylor College of Medicine, holding joint appointments in the Verna & Marrs McLean Department of Biochemistry & Molecular Biology, the Center for Precision Environmental Health, and the Department of Molecular and Cellular Biology. He also serves as a Faculty Senator and member of multiple graduate programs. His research focuses on epigenetics and chromatin biology, particularly histone proteoforms and their roles in cancer. Young employs advanced top-down proteomics and mass spectrometry techniques to study combinatorial post-translational modifications (PTMs) and their functional implications. Education: Postdoctoral Fellowship at Princeton University (Molecular Biology), PhD from University of California, Davis (Molecular Biology), and BS from UC Berkeley (Bioanalytical Chemistry). Research interests include histone PTM dynamics, epigenetic regulation, and the development of proteomics tools for precision medicine. Current projects explore histone proteoform responses to epigenetic inhibitors, histone variants in cancer, and transcription factor proteoforms. His lab collaborates on drug resistance mechanisms and DNA damage responses, with a focus on translating findings into therapeutic strategies. Young has advised PhD students like Matthew V. Holt and Tao Wang. His lab’s innovations in top-down proteomics have enabled quantitative analysis of chromatin components, advancing understanding of epigenetic signaling and disease mechanisms.

Daniel McDevitمشاهده پروفایل

دانشیار

• Ecology
• Marine Biology
• Algal Taxonomy
• +۳ مورد دیگر

Dr. Daniel McDevit is an Associate Professor in the Department of Biological Sciences at the University of Delaware (UD), specializing in the Associate in Arts Program (AAP) at the Wilmington Campus. He also serves as the Disability Support Services (DSS) Coordinator for UD’s Wilmington campus. His academic background includes a Ph.D. in Biology from the University of New Brunswick, an M.Ed. in Curriculum and Instruction from Boston College, and a B.S. in Biology from Trinity College. Prior to joining UD, he taught biology at Florida SouthWestern State College in Florida. Dr. McDevit’s research spans diverse areas including algal biodiversity, seaweed taxonomy, and ecology of marshland habitats. He actively explores the biology of honeybees through UD’s AAP beehives and investigates the impact of hands-on research in science education. His work has contributed significantly to understanding species diversity via DNA barcoding, particularly in Canadian marine algae and Bermudian Rhodophyta. He teaches a range of biology courses, including Principles of Biology, Human Heredity, and Evolutionary Ecology. His publications reflect expertise in molecular systematics, ecological adaptations, and immunology. He has presented extensively on topics such as algal biodiversity, barcoding methodologies, and immune system gene regulation. Dr. McDevit’s academic contributions include lab manuals and methodological chapters on DNA barcoding, emphasizing practical applications in marine biology. His roles in education and accessibility highlight his dedication to fostering inclusive and experiential learning environments.

Greg M. Forestمشاهده پروفایل

استاد

• Biomedical Engineering
• Applied Mathematics
• Biophysics
• +۳ مورد دیگر

Greg M. Forest is a Professor of Biomedical Engineering and the Grant Dahlstrom Distinguished Professor of Mathematics at the University of North Carolina. His research focuses on the intersection of applied mathematics, biophysics, and biomedical engineering, with emphasis on biomaterials, mucus rheology, and infectious disease modeling. He leads interdisciplinary projects involving polymer networks, viral transport mechanisms, and computational modeling of biological systems. His work bridges experimental, statistical, and theoretical approaches to address challenges in healthcare and material science. Key research interests include: biophysical analysis of mucus in cystic fibrosis, mathematical modeling of viral infections (e.g., SARS-CoV-2), polymer nanocomposite design, and the dynamics of biomolecular condensates. He has contributed to advancing techniques like particle tracking microrheology and computational fluid dynamics for biological systems. His research has been supported by grants such as the RAPID initiative for lung mucus strategies against COVID-19 and collaborative projects on liquid-liquid phase separation in cellular compartments. He is affiliated with the Statistical and Applied Mathematical Sciences Institute (SAMSI), emphasizing interdisciplinary mathematical applications. Publications highlight trends in mucus heterogeneity, viscoelastic fluid dynamics, and crosslinker optimization for biomedical applications. While no formal awards are listed, his distinguished professorship reflects recognition of his scholarly contributions.

Marcin Przewlokaمشاهده پروفایل

مدرس

• Molecular Cell Biology
• Chromosome Biology
• Cell Division
• +۳ مورد دیگر

Dr. Marcin Przewloka is a Lecturer in Molecular Cell Biology at the University of Southampton, UK. He holds a PhD in Biology from the University of Warsaw and has held research positions at the University of Cambridge and Albert Einstein College of Medicine. His research focuses on mitotic cell division mechanisms, chromosome segregation, and kinetochore function. He teaches courses such as Cancer Chromosome Biology and supervises PhD students in these areas. Education: PhD in Biology, University of Warsaw, 2000 MSc in Biology, University of Warsaw, 1995 Postgraduate Certificate in Academic Practice, University of Southampton, 2018 Research Interests : Control of mitotic cell division Chromosome biology and centromere/kinetochore dynamics Protein post-translational modifications in cell cycle regulation Multi-protein complexes in cell biology Research Projects : Assembly and regulation of kinetochores in human/non-transformed and cancer cells (Royal Society) Novel role of protein phosphatase in chromosome segregation (Wellcome Trust) Labs/Teams: Member of Cell and Developmental Biology Institute for Life Sciences at the University of Southampton.

Michele Berselliمشاهده پروفایل

پژوهشگر ارشد

• Bioinformatics
• Computational Biology
• Genomics
• +۵ مورد دیگر

Michele Berselli is a Research Fellow in Biomedical Informatics at Harvard Medical School, Department of Biomedical Informatics. He is an active member of the 4DNucleome Data Coordination and Integration Center, where he specializes in developing and implementing automated pipelines and genomic workflows in cloud computing environments, particularly Amazon Cloud. Dr. Berselli earned his PhD in 2019 from the University of Padova, where his dissertation research focused on computational approaches to studying nucleic acid secondary structures. During his doctoral studies, he developed two innovative algorithms: nessie for identifying approximate DNA sequence symmetries and QPARSE for detecting long-looped or multimeric G-quadruplex structures. He also contributed to a comprehensive web-database evaluating G-quadruplex structures in human viruses, demonstrating his early expertise in non-canonical DNA structures and bioinformatics tool development. His research interests span bioinformatics, computational genomics, and structural biology, with particular expertise in G-quadruplex structures, DNA sequence analysis, and genomic workflow automation. Dr. Berselli's work bridges computational methodology development with biological applications, creating tools that enable deeper understanding of genomic architecture and function. His research has evolved from fundamental algorithm development for DNA structure analysis to more applied work in clinical genomics and viral genomics. An analysis of his publication record reveals a consistent trajectory of innovation in bioinformatics tool development. His work shows progression from specialized algorithms for DNA structure analysis (nessie, QPARSE) to broader genomic analysis tools (Chromoscope, BamSnap, GBRAP). Recent publications demonstrate increasing focus on clinical applications, particularly in rare disease diagnosis through genomic analysis. This evolution reflects the growing importance of computational approaches in translating genomic discoveries to clinical practice. As a member of the Harvard Medical School faculty, Dr. Berselli collaborates extensively with researchers across multiple laboratories, contributing his expertise in cloud-based genomic workflows and pipeline development to advance biomedical research. His work with the 4DNucleome initiative positions him at the forefront of research on three-dimensional genome organization and its functional implications.

Robert J. Duronioمشاهده پروفایل

استاد

• Epigenetics
• Cell Cycle Regulation
• Developmental Genetics
• +۳ مورد دیگر

Robert J. Duronio is a Professor of Biology and Genetics, and Chair of the Department of Biology at the University of North Carolina at Chapel Hill. He is also affiliated with the Lineberger Comprehensive Cancer Center and the Integrative Program for Biological and Genome Sciences. His research focuses on the epigenetic and cell cycle-regulated mechanisms controlling genome structure and function in Drosophila, particularly the interplay between chromatin organization, histone gene expression, and DNA replication during development. Duronio's work employs genetic, genomic, and cell biological approaches to study the histone locus body, a phase-separated nuclear body critical for histone mRNA biosynthesis and cell cycle progression. His research group investigates how histone gene transcription is temporally and spatially coordinated with S-phase progression, as well as the roles of histone variants and post-translational modifications (e.g., H3K4, H3K36, H4K20) in regulating chromatin structure and Polycomb-mediated gene silencing. Recent studies highlight the plasticity of cell cycle control during development and the functional consequences of histone locus body dysregulation on genomic stability. Affiliations: School of Medicine, Department of Biology, Department of Genetics Labs: Duronio Lab (focused on developmental cell cycle control and epigenetic mechanisms)

Rifka Vlijmمشاهده پروفایل

استادیار

• Cell Biology
• Biophysics
• Super-Resolution Microscopy
• +۵ مورد دیگر

Rifka Vlijm is an Assistant Professor at the University of Groningen's Faculty of Science and Engineering, within the Molecular Biophysics department. She specializes in super-resolution microscopy, particularly STED, to study cellular protein structures and cell division mechanisms. Her research emphasizes developing live-cell imaging techniques, including high-throughput protocols, machine-learning integration, and non-toxic imaging methods. Education and Career: PhD at TU Delft with Prof. Cees Dekker (single-molecule chromatin studies), Postdoc at NIH (centromere DNA stability), and STED microscopy expertise under Nobel laureate Stefan Hell. Joined Groningen in 2019 as a tenure-track faculty member. Research Interests: Focus on ESCRT-III polymer dynamics, centrosome linkers, peroxisomal proteins, and microscopy innovations. Key contributions include STED-based cell division visualization in archaea and live-cell yeast protocols. Awards and Grants: 2022 NWO-M1 Grant, FSE Research Grant, NWO-XL Grant (consortium). Nominated for Aspasia Prize (2023). Active in national advisory roles, including NWO committees and the Dutch Biophysics organization. Grants and Networks: Member of APNet (national network for assistant professors), advisory boards for NWO work councils, and conference leadership roles. Her lab's innovations span microscopy automation and interdisciplinary collaborations.

• Genomic organization
• Chromatin structure
• Gene cluster regulation
• +۶ مورد دیگر

Ya-Chen Liang, PhD is an Assistant Professor of Research Pathology at the Keck School of Medicine of the University of Southern California. Her research focuses on understanding the functional organization of genomes and sub-nuclear structures within cell nuclei, particularly how these structures maintain flexibility to respond to biological cues during development and disease pathogenesis. Dr. Liang's primary research interest centers on the spatial regulation of gene clusters, which are widespread in genomes but whose inter-cluster and subnuclear organizations remain poorly understood. Her work integrates state-of-the-art functional genomic, computational, and proteomic approaches to address fundamental questions at the intersection of topological chromatin states and spatial subnuclear protein scaffolds. She has made significant contributions to understanding how keratin gene clusters fold during skin regional specification, the role of SATB2 in keratin gene cluster switching, and the mechanisms underlying pigment pattern formation in avian skin. Analysis of Dr. Liang's publication record reveals a consistent focus on the spatial organization of the genome and its relationship to developmental processes, particularly in skin and integumentary organ development. Her work spans multiple model systems including avian and mammalian models, with a particular emphasis on understanding how chromatin architecture influences tissue-specific gene expression during development and regeneration. A notable trend in her research is the integration of cutting-edge genomic technologies with traditional developmental biology approaches to uncover the principles governing spatial gene regulation. Ministry of Science and Technology, Taiwan: Overseas Postdoctoral Program for Frontier Technologies, 2014-2016 Dr. Liang's laboratory is actively recruiting graduate students and postdoctoral fellows, indicating her role as a research advisor and mentor. While specific grant information isn't detailed in the available text, her research program appears to be well-established with consistent publication output across multiple high-impact journals. Her collaborative network includes prominent researchers in developmental biology, particularly within the USC research community. Dr. Liang maintains an active research laboratory focused on genomic organization and its role in development. Her work bridges molecular biology, genomics, and developmental biology, creating a unique interdisciplinary approach to understanding how spatial genome organization contributes to tissue-specific gene expression during development and disease.

Leonardo Morsutمشاهده پروفایل

استادیار

• Synthetic Biology
• Stem Cell Biology
• Regenerative Medicine
• +۳ مورد دیگر

Leonardo Morsut is an Assistant Professor in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine, University of Southern California. His research focuses on synthetic biology and tissue engineering, aiming to program mammalian cells for controlled tissue morphogenesis and regeneration. He leads the Morsut Lab, which integrates computational modeling, protein engineering, and stem cell biology in an iterative framework to understand and manipulate tissue self-organization. University: University of Southern California School: Keck School of Medicine Department: Stem Cell Biology and Regenerative Medicine Academic Rank: Assistant Professor Research Interests: Dr. Morsut's work combines synthetic biology with developmental systems to engineer multicellular constructs. His lab specializes in synthetic Notch receptors, genetic circuit design, and controlling spatio-temporal patterning during tissue formation. Key areas include programmable material-to-cell pathways, juxtacrine signaling networks, and computational frameworks for morphogenesis modeling. Recent Publications Trends: His 2024-2025 studies emphasize precise spatial control of differentiation in organoids using synthetic Wnt organizers, programmable material interfaces, and dynamic cell growth feedback. Earlier works focus on transgene silencing mechanisms, mucin-driven morphogenesis, and density-dependent signaling in multicellular systems. Laboratory Mission: The Morsut Lab aims to build functional tissues through synthetic biology tools while training future regenerative medicine leaders. They utilize interdisciplinary approaches from engineering, computational biology, and developmental systems to create programmable multicellular structures.

• DNA Replication
• Chromosome Maintenance
• Cell Biology
• +۵ مورد دیگر

Dr. Shin-Ichiro Hiraga is a Senior Lecturer at the University of Aberdeen's School of Medicine, Medical Sciences and Nutrition, based at the Institute of Medical Sciences. His research focuses on mechanisms of chromosome maintenance and DNA replication, using yeast and human cell models. He investigates RIF1 and SAF-A proteins' roles in replication stress response and epigenetic regulation. Key collaborators include Prof. Anne Donaldson and international researchers from institutions like Osaka University and the Crick Institute. Education: BSc (1990) and PhD (1996) from Osaka University. He holds a Fellowship of the Higher Education Academy (FHEA, 2023). Professional memberships include the Biochemical Society, Genetics Society, and Molecular Biology Society of Japan. He serves as an editorial board member for Journal of Biochemistry and reviewer for high-impact journals. Research interests span DNA replication initiation, fork protection, and epigenetic stability. His work bridges fundamental biology and translational applications in cancer prevention. Techniques used include proteomics, super-resolution microscopy, and genome-wide approaches. Major grants include a £1.5M Cancer Research UK Programme Award (2017) and a Daiwa Anglo-Japanese Foundation grant (2019). Teaching responsibilities include advanced molecular biology and biochemistry courses. His lab explores how chromatin structure and protein complexes regulate DNA replication under stress conditions, with recent findings on SAF-A's role in 3D genome organization and replication robustness.

• Molecular Biology
• Microbiology
• Genetics
• +۵ مورد دیگر

Takashi Kubota is a Lecturer in the Institute of Medical Sciences at the University of Aberdeen. His primary affiliation is within the School of Medicine, Medical Sciences and Nutrition. He holds a B.Sc. (2003) and PhD (2008) in Molecular Biology from Tokyo University of Science. His research focuses on mechanisms of antifungal drug resistance, particularly in Candida species, and the role of chromatin remodeling complexes like SWI/SNF and histone chaperones in regulating multidrug transporter expression. He has also studied DNA replication processes, including PCNA unloading and genome integrity maintenance through the Elg1 complex. Key roles include co-organizing the IMS-Rowett PI seminar series, serving on the Foresterhill Biological Safety Committee, and leading his own research group since 2019. His grants include a BBSRC New Investigator Grant (2024-2027) and prior MRC Career Development Fellowship (2014-2019). He supervises PhD students in Biomedical Sciences and teaches courses in Molecular Microbiology and Bioinformatics. Research themes span fungal drug resistance, chromatin dynamics, and DNA repair mechanisms, with recent work emphasizing novel methods to identify promoter-bound proteins and combat drug-resistant pathogens. His lab’s work has implications for understanding Candida infections and developing therapeutic strategies against multidrug resistance.

Francisca Lottersbergerمشاهده پروفایل

دانشیار

• Genome Integrity
• Chromatin Mobility
• DNA Damage Response (DDR)
• +۴ مورد دیگر

Francisca Lottersberger is an Associate Professor and Docent at Linköping University's Department of Biomedical and Clinical Sciences (BKV), affiliated with the Division of Molecular Medicine and Virology. Her research focuses on genome integrity maintenance, particularly chromatin mobility's role in DNA repair and cancer development. She leads a laboratory investigating DDR pathways to develop diagnostic and therapeutic tools for cancer. Education & Career: Master's degree, University of Milano-Bicocca, Italy (2002) PhD, University of Milano-Bicocca, Italy (2006) Postdoctoral research at University of Milano-Bicocca (2006) and The Rockefeller University, NY, USA (2017) Research Interests: Her work combines mouse genetics and imaging to study chromatin dynamics in cancer and aging. Key areas include: DSB repair mechanisms Chromatin mobility's impact on genome stability Cancer therapeutic vulnerabilities Grants & Funding: Recipient of 24 million SEK from the Swedish Cancer Society (2021) Part of a 64 million SEK grant from the Swedish Research Council (2021) Lab & Collaborations: Her team includes PhD student Elena Faustini, research preparatory student Bartosz Malinski, and medical student Omar Islam. She collaborates with the Wallenberg Centre for Molecular Medicine, focusing on medical-technology interfaces in cancer research.