جست‌وجوی استاد و پژوهشگر

Nathan Luedtkeمشاهده پروفایل

استاد

• Chemical Biology
• Nucleic Acid Probes
• Organic Chemistry
• +۳ مورد دیگر

Nathan Luedtke is a Full Professor in the Department of Chemistry at McGill University's Faculty of Science. He holds a B.Sc. from the University of Washington (1997), Ph.D. from UC San Diego (2003), completed an NIH Postdoctoral Fellowship at Yale University (2003-2006), and served as Professor at the University of Zürich (2006-2019). His laboratory develops non-toxic fluorescent probes for studying nucleic acid structure and dynamics in live cells and animals. Research focuses on designing fluorophores and nucleosides through synthetic chemistry, with applications in regenerative medicine, stem cell biology, virology, and cancer diagnostics. Commercialized probes are distributed by Sigma Aldrich. Current teaching includes courses in Organic Chemistry and Advanced Nucleic Acid Chemistry. Honors include: NIH Postdoctoral Fellowship

Mathew Jonesمشاهده پروفایل

مدرس ارشد

• Cancer Genetics
• Cell Biology
• DNA Replication
• +۴ مورد دیگر

Dr Mathew Jones serves as Senior Lecturer in the School of Chemistry and Molecular Biosciences at the University of Queensland and holds a Senior Research Fellow position at the Frazer Institute. His molecular genetics research group operates at the intersection of cancer biology and DNA repair mechanisms, with active supervision of multiple PhD students across diverse projects. His primary research focuses on exploiting cancer-specific vulnerabilities in DNA replication, repair pathways, and cellular metabolism to develop targeted therapies. Key areas include replication stress responses, mitotic regulation, chromosomal instability, and the interplay between DNA damage response and immune activation. His work combines cutting-edge molecular biology, genomics, and computational approaches to translate basic discoveries into therapeutic strategies. Analysis of his 15 most recent publications reveals a strong emphasis on DNA replication stress mechanisms (40% of papers), mitophagy regulation in cancer metabolism (20%), and chromosomal instability pathways (25%). His 2025 publications particularly highlight innovative applications of nanopore sequencing for cancer diagnostics and novel PARP1 inhibition mechanisms. Principal Investigator for 2023-2025 Schrodinger Inc. grant: 'Define the mode of action for Cdc7 inhibition in TP53 wild type and mutant Acute Myeloid Leukemia (AML)' Lead on 2021-2023 ARC Discovery Project: 'Decoding the spatiotemporal control of DNA replication and repair' Current supervision of 4 PhD students including projects on cGAS/STING pathway regulation and iPSC-NK cell immunotherapy His research group maintains active collaborations with the Frazer Institute's clinical research facilities, bridging laboratory discoveries with patient-oriented applications through the Frazer Institute's translational research framework.

• Gene Expression Regulation
• Epigenetics
• Single-Cell Genomics
• +۴ مورد دیگر

Hojoong Kwak is an Assistant Professor in the Department of Molecular Biology and Genetics at Cornell University, affiliated with the College of Agriculture and Life Sciences (CALS). He is also a member of the Graduate Field of Biochemistry, Molecular and Cell Biology. His research focuses on the regulation of gene expression and single-cell genomics, particularly investigating enhancer RNAs, epigenetic mechanisms in osteoclast differentiation, and RNA processing dynamics. His lab employs innovative techniques like TED-Seq and PRO-seq to study transcriptional and post-transcriptional regulation in diverse biological systems. Key research interests include the interplay between transcription factors and enhancer elements, RNA polymerase activity in cancer and immune cells, and the role of post-transcriptional modifications such as polyadenylation and m6A methylation. His work spans molecular mechanisms in bone biology, inflammatory responses, and cancer cell behavior under chemotherapeutic stress. Dr. Kwak teaches advanced biochemical methods (BIOMG 8310) and oversees independent undergraduate research (BIOG 4990). His recent publications highlight contributions to understanding epigenetic reprogramming in macrophages, RNA dynamics during cellular activation, and the structural basis of RNA processing enzymes like Dbr1. Though no specific awards are listed, his research reflects a commitment to cutting-edge methodologies in genomics and molecular biology. His work integrates computational analysis with experimental approaches to uncover cell-type specific transcriptional programs, particularly in peripheral blood cells and glioblastoma. Ongoing projects likely explore the functional implications of enhancer RNAs and the systems-level control of gene expression across diverse cellular contexts.

Lisa Smithمشاهده پروفایل

مدرس ارشد

• Plant Reproduction
• Receptor Kinases
• Epigenetics
• +۵ مورد دیگر

Dr Lisa Smith is a Senior Lecturer at the School of Biosciences, University of Sheffield (2024–present), following roles as Lecturer (2013–2023) and Postdoctoral Fellow at the Max Planck Institute (2007–2013). She holds a PhD from The Sainsbury Laboratory and a BSc from The University of Queensland. Her research focuses on plant reproduction, receptor kinases, and epigenetic regulation. Key projects include studying malectin domain proteins in fertilization and cell division, funded by BBSRC and Leverhulme Trust grants. She collaborates with groups at the University of Sheffield and internationally. Teaching includes modules on plant form/function and future plant biotechnology. The Smith Lab emphasizes inclusivity and investigates plant adaptation through epigenetics and transposable elements. Research Interests: Plant reproduction signaling, receptor kinase function (e.g., HERK1/ANJ proteins), epigenetic mechanisms in stress adaptation, and transposable element dynamics. Recent work highlights roles in pollen tube reception, cell division motor proteins, and transgenerational epigenetic memory. Grants & Collaboration: BBSRC-responsive grant for receptor kinase studies, Leverhulme Trust grant for kinesin research. Collaborates with Andrew Fleming, Sam Amsbury, and external partners on epigenetics and plant development. Lab Activities: Hosts postdocs (Alice Baillie, Louis Tirot) and technicians (Peijun Zhang). Offers PhD opportunities via Yorkshire Biosciences DTP, focusing on plant reproduction, epigenetics, and cell division.

Mark Collinsمشاهده پروفایل

مدرس ارشد

• Proteomics
• Neurodegenerative Diseases
• Neuroscience
• +۳ مورد دیگر

Dr. Mark Collins is a Senior Lecturer in Biological Mass Spectrometry and Deputy Director of the Mass Spectrometry Centre at The University of Sheffield's School of Biosciences. His expertise lies in proteomics, focusing on post-translational modifications (PTMs) such as palmitoylation and their roles in neurodegenerative diseases like Alzheimer's and ALS. He holds a PhD in Neuroscience from the University of Edinburgh and has extensive postdoctoral experience at the Wellcome Trust Sanger Institute. Education: PhD in Neuroscience, University of Edinburgh (2001-2005) BSc in Biochemistry, University College Dublin (1996-2000) His research interests include neuroproteomics, palmitoylation regulation, and ALS pathogenesis. He employs advanced mass spectrometry techniques to study protein dynamics and signaling pathways. Key collaborations include work with Prof. Shaun Cowley (University of Leicester) and Prof. Pamela Shaw (University of Sheffield). Dr. Collins teaches modules in cell/molecular biosciences and directs the Mass Spectrometry-based Proteomics and Metabolomics course. He has secured grants from BBSRC, MRC, and other organizations. His articles highlight contributions to understanding bacterial pathogenesis, epigenetic regulation, and ALS biomarkers. He supervises multiple PhD students and co-leads the Mass Spectrometry Centre, supporting interdisciplinary research in proteomics.

Patrick J. Murphyمشاهده پروفایل

استادیار

• Epigenetics
• Gene Regulation
• Developmental Biology
• +۴ مورد دیگر

Patrick J. Murphy is an Assistant Professor in the Department of Biology at the University of Rochester’s School of Arts & Sciences. His research focuses on mechanisms governing gene expression during development and disease, particularly using zebrafish and mammalian models to study epigenetic regulation of cell identity transitions. He earned a PhD and holds expertise in chromatin dynamics, developmental genomics, and bioinformatics. Research Interests include: Regulation of vertebrate gene transcription in vivo Epigenetic and chromatin dynamics Zebrafish genetics & genomics Developmental cell state transitions Advanced genomic technologies Publications span topics like histone chaperones in neurons, pluripotency reacquisition, and paternal epigenetic effects of smoking. His work combines classic developmental biology with modern genomics and bioinformatics tools. No scientific awards are explicitly listed, though his high-impact publications reflect significant contributions. Advising no listed students, but collaborates on projects involving chromatin and epigenetic reprogramming. Active in the Murphy Lab, which leverages zebrafish systems for mechanistic insights into gene regulation.

• Plant Genomics
• Epigenetics
• Biotechnology
• +۳ مورد دیگر

Dr Buddhini Ranawaka is a Postdoctoral Research Fellow at the School of Biology & Environmental Science, Faculty of Science, Queensland University of Technology (QUT). Her research focuses on plant genomics, epigenetics, and biotechnology, with particular emphasis on crops like wheat and Nicotiana benthamiana. She investigates comparative genomics between rice and wheat, viral disease dynamics in plants, and molecular techniques for studying epigenetic modifications in plants. Her work includes developing multi-omic resources for fundamental research and biotechnological applications, optimizing chromatin immunoprecipitation methods, and exploring in vitro tissue culture technologies for crop improvement. Dr. Ranawaka’s contributions span plant pathology, molecular biology, and agricultural science, with publications in journals such as Crop Journal , Nature Plants , and Viruses .

Ross Alexanderمشاهده پروفایل

استادیار

• Plant Biology
• Molecular Genetics
• Stress Response in Plants
• +۳ مورد دیگر

Ross Alexander is an Assistant Professor at the School of Energy, Geoscience, Infrastructure and Society at Heriot-Watt University, within the Institute for Life and Earth Sciences. He specializes in plant molecular biology, focusing on stress response mechanisms, transcription factors, and RNA processing. His research contributes to UN Sustainable Development Goals related to sustainable agriculture and environmental protection. Key research interests include osmotic stress regulation in plants, zinc homeostasis, drought tolerance, and the molecular underpinnings of RNA splicing. His work integrates genetics, proteomics, and computational modeling to uncover mechanisms governing plant resilience under stress conditions. Publications highlight breakthroughs in understanding Arabidopsis genetics, barley transcription factors, and RNA polymerase dynamics. His findings are disseminated in top journals like Nature Plants and eLife , with significant citations and media coverage. Affiliations include collaborations across international institutions, focusing on plant stress biology and molecular genetics. Ross Alexander actively mentors PhD students in these domains and is currently accepting new candidates.

Yongsheng Shiمشاهده پروفایل

استاد

• RNA Processing
• Molecular Biology
• Gene Expression Regulation
• +۴ مورد دیگر

Yongsheng Shi is a Professor & Chancellor's Fellow in the Department of Microbiology & Molecular Genetics at the University of California, Irvine (UCI). His research focuses on the molecular mechanisms of RNA processing, particularly mRNA 3' end formation, polyadenylation, and their roles in gene expression regulation. He investigates how these processes influence cellular differentiation, viral pathogenesis, and cancer biology. Key research interests include transcriptome surveillance, RNA-protein interactions, and the interplay between RNA processing and epigenetic regulation. His work employs cutting-edge techniques like PAS-seq and massively parallel reporter assays, combined with machine learning approaches, to decode complex RNA regulatory networks. Shi's publications highlight contributions to understanding herpes simplex virus effects on host mRNA processing, the role of polyadenylation in stem cell self-renewal, and the functional implications of RNA structure in gene regulation. His findings bridge basic molecular mechanisms with translational applications in cancer therapy and viral infections. He holds the prestigious Chancellor's Fellow title at UCI, reflecting recognition of his scholarly contributions. His research has implications for understanding fundamental biological processes and developing therapeutic strategies targeting RNA machinery.

Terry Magnusonمشاهده پروفایل

استاد

• mammalian genetics
• genomics
• chromatin remodelers
• +۳ مورد دیگر

Terry Magnuson is the Kay M. and Van L. Weatherspoon Eminent Distinguished Professor of Genetics and founding chair of the Department of Genetics at the University of North Carolina at Chapel Hill School of Medicine. He leads key initiatives in the Carolina Center for Genome Sciences and the Cancer Genetics program. As Vice Dean for Research and Strategy in the School of Medicine and School of Data Science and Society, he oversees research strategy and interdisciplinary collaboration. His academic roles include secondary appointments in the School of Data Science and Society and leadership in NIH committees, the National Academies Regenerative Medicine forum, and the All of Us advisory committee. Educated at Cornell University (Ph.D.) and the University of California, San Francisco (postdoc), Magnuson’s research focuses on chromatin remodeling in mammalian development, epigenetic regulation, and mouse models of human disease. His lab explores mechanisms of gene function in cancer, meiosis, and stem cell pluripotency. Notable contributions include advancing the Mutant Mouse Resource and Research Center (MMRRC) as a critical genetic resource for biomedical research. Scientific highlights include discoveries on ARID1A’s role in sex-linked gene silencing during male meiosis and INO80’s regulation of chromatin accessibility in spermatogenesis. His work bridges fundamental epigenetics with translational applications in disease modeling. Awards include membership in the American Academy of Arts and Sciences, AAAS, and the National Academy of Medicine. Leadership extends to managing university-wide research initiatives, policy development for genomic studies, and fostering collaboration across disciplines. His contributions to mouse genetic standards (e.g., MiniMUGA genotyping array) ensure reproducibility in preclinical research. Current efforts emphasize leveraging genomic data to address complex biological questions and improve experimental rigor.

Daniel J. McKayمشاهده پروفایل

دانشیار

• Developmental Genomics
• Chromatin Accessibility
• Histone Modifications
• +۳ مورد دیگر

Daniel J. McKay is an Associate Professor in the Department of Biology and Genetics at the University of North Carolina at Chapel Hill. His research focuses on understanding how genomes direct cell fate decisions during development using Drosophila as a model system. Key interests include transcription factor regulation of chromatin accessibility and epigenetic mechanisms mediated by histone modifications. Research in the McKay Lab integrates genomic approaches like ChIP-seq with Drosophila genetics to study gene expression dynamics and their role in diseases like cancer. The lab’s work bridges fundamental developmental biology with insights into human health applications. Key Research Themes: Chromatin accessibility and transcription factor interactions Epigenetic regulation via histone post-translational modifications Genetic engineering of histone gene clusters Recent publications emphasize discoveries about histone H3 variants, Polycomb silencing mechanisms, and enhancer regulation in developmental contexts. The lab is actively recruiting postdoctoral and graduate researchers interested in developmental genomics.

Arianna Baggioliniمشاهده پروفایل

استادیار

• Cancer Biology
• Neuroscience
• Stem Cell Biology
• +۳ مورد دیگر

Arianna Baggiolini is an Assistant Professor at the Università della Svizzera italiana (USI), affiliated with the Institute of Oncology Research (IOR) in the BIOS+ network. She leads an independent research group focusing on melanoma oncogenic competence, developmental chromatin programs, and stem cell biology. Previously, she completed a postdoctoral fellowship at Memorial Sloan Kettering Cancer Center (MSKCC) under Dr. Lorenz Studer, where she explored neural crest development and melanoma formation. Her education includes a BSc and MSc in Biology from ETH Zurich and a PhD in Neuroscience from the University of Zurich. Key contributions include defining oncogenic competence in melanoma and elucidating roles of developmental chromatin factors in tumor initiation and neural maturation. Baggiolini’s research integrates cancer biology, stem cell engineering, and developmental pathways to uncover mechanisms underlying tumor progression and therapeutic vulnerabilities. Her work has been recognized with prestigious awards such as the Christopher J. Marshall Award (Society for Melanoma Research), SNSF Starting Grant, and the Hofschneider Professorship. Current research emphasizes lipid metabolism in melanoma, epigenetic barriers to neuronal maturation, and translational approaches to modulate glial cells in spinal cord injury. Baggiolini’s lab employs cutting-edge techniques like patient-derived organoids and CRISPR-based models to study tumor heterogeneity and cellular plasticity. She actively collaborates on projects addressing neurodevelopmental disorders and cancer stem cell therapies, with a focus on translating basic discoveries into clinical applications.

Ruth Finkelsteinمشاهده پروفایل

استاد

• Plant Biology
• Molecular Genetics
• Signal Transduction
• +۳ مورد دیگر

Ruth Finkelstein is a Professor in the Department of Molecular, Cellular, and Developmental Biology at the University of California, Santa Barbara (UCSB). Her research focuses on the molecular mechanisms of abscisic acid (ABA) signaling in plants, particularly its role in seed development, dormancy, and stress responses. She has been a faculty member since 1989 and previously served as a Monitoring Editor for Plant Physiology (2000–2005) and Associate Dean for the Division of Mathematical, Life, and Physical Sciences (2006–2008). Dr. Finkelstein earned her Ph.D. in Molecular, Cellular, and Developmental Biology from Indiana University in 1986. Her postdoctoral work at Michigan State University’s Plant Research Laboratory (1986–1988) expanded her expertise in genetic approaches to study ABA signaling. Her lab uses genetic, molecular, and physiological tools to dissect ABA’s role in regulating plant growth and stress responses, with applications in crop improvement. Her research integrates ABA signaling pathways with cross-talk involving other hormones, nutrient status, and environmental cues. Key contributions include identifying transcription factors like ABI4 and ABI5, and elucidating interactions between ABA signaling proteins and chromatin modifiers. These studies aim to develop models for ABA’s role in seed quality, yield, and stress tolerance. Notable affiliations: Finkelstein Lab, Department of Molecular, Cellular, and Developmental Biology (MCDB), Division of Mathematical, Life, and Physical Sciences at UCSB.

Mattia Frontiniمشاهده پروفایل

دانشیار

• Genetics
• Obesity
• Platelet Biology
• +۲ مورد دیگر

Dr. Mattia Frontini is an Associate Professor whose research investigates genetic and epigenetic mechanisms of metabolic diseases, thrombosis, and platelet biology. His discoveries include novel obesity-related genetic factors like SMIM1 deficiency impacting energy expenditure and pioneering work on platelet transcriptomics in hemostatic disorders. Frontini employs multi-omics approaches and functional genomics to link regulatory variants with disease pathogenesis.

Nadine Vastenhouwمشاهده پروفایل

دانشیار

• Developmental Biology
• Molecular Biology
• Genomics
• +۳ مورد دیگر

Nadine Vastenhouw is an Associate Professor at the University of Lausanne's Center for Integrative Genomics (CIG), part of the Faculty of Biology and Medicine. She leads a research group focusing on transcriptional regulation during vertebrate embryogenesis, particularly in zebrafish. Her work explores how chromatin structure and transcriptional machinery interact to regulate embryonic development during the maternal-to-zygotic transition. She has held positions at Harvard University, the Max Planck Institute in Dresden, and joined UNIL in 2020. Her research is funded by organizations including EMBO, HFSP, NIH, and the Max Planck Society. Education: Masters in Medical Biology, Amsterdam PhD at Hubrecht Institute (Utrecht), studying RNA interference in C. elegans Postdoctoral research at Harvard University, investigating zebrafish embryology Research Interests: Her lab combines molecular biology, genomics, and biophysics to study how transcriptional programs are established during early embryonic development. Key areas include: Chromatin dynamics during genome activation Role of epigenetic factors in developmental transitions Mechanisms linking maternal and zygotic gene expression Labs & Teams: She leads the Vastenhouw Lab at CIG, located in Lausanne. The lab focuses on interdisciplinary approaches to understand transcriptional regulation in zebrafish embryos.