جستجوی استاد راهنمای دانشگاهی

Diane Barberمشاهده پروفایل

استاد

• Cell Biology
• Cancer Biology
• Stem Cell Research
• +۳ مورد دیگر

Dr. Diane Barber is a Professor in the Department of Cell and Tissue Biology at the University of California San Francisco (UCSF). Her research focuses on epithelial plasticity and the role of intracellular pH dynamics in regulating cancer and stem cell behaviors. Key areas include protonation as a post-translational modification, actin filament regulation, and epithelial-to-mesenchymal transition. Her work bridges protein electrostatics with cell biology, emphasizing how pH imbalances drive cancer progression and stem cell differentiation. Recent studies highlight pH's role in transcription factor activity, lysosomal pH in cancer cells, and structural biology of glycolytic enzymes like phosphofructokinase-1. Dr. Barber’s lab employs advanced biosensors and structural approaches to uncover mechanisms linking metabolic signals to cell fate decisions. Collaborations span immunology, cancer biology, and developmental biology, with a focus on translational applications in therapeutic targeting.

Andrei Gogaمشاهده پروفایل

استاد

• Oncology
• Cancer Biology
• Cell Biology
• +۴ مورد دیگر

Andrei Goga, MD, PhD is a Professor in the Department of Cell and Tissue Biology at the University of California San Francisco (UCSF) School of Medicine. His research focuses on understanding how oncogenes like MYC drive tumorigenesis through cell cycle, miRNA, and metabolic signaling pathways. The Goga Lab investigates therapeutic strategies targeting MYC-driven cancers, including triple-negative breast cancer and liver malignancies. Recent work highlights tumor microenvironment interactions, immune evasion mechanisms, and drug resistance pathways. Key research areas include: MYC oncogene biology and synthetic-lethal interactions Metastasis mechanisms and tumor plasticity Mitochondrial metabolism in cancer progression Combination immunotherapy strategies Publications highlight breakthroughs in understanding microbiota-drug interactions, mitochondrial reprogramming, and single-cell analysis of metastatic progression. Ongoing clinical trials evaluate novel therapies targeting cancer metabolism and immune checkpoints. Laboratory facilities include advanced metabolic imaging capabilities and collaboration with the UCSF Helen Diller Family Comprehensive Cancer Center. Current projects focus on translating molecular discoveries into clinical applications for hard-to-treat cancers.

Tao Yangمشاهده پروفایل

دانشیار

• Skeletal development
• Osteoarthritis
• Osteoporosis
• +۴ مورد دیگر

Tao Yang, Ph.D. is an Associate Professor in the Department of Cell Biology at Van Andel Institute (VAI). His research focuses on molecular mechanisms underlying skeletal development, stem cell fate determination, and skeletal aging, with an emphasis on gene and stem cell therapies for diseases like osteoarthritis and osteoporosis. Dr. Yang leads the Yang Lab, which employs multi-omics approaches, skeletal disease models, and advanced molecular techniques. Education & Career: B.S. in Biochemistry, Wuhan University Ph.D. in Biochemistry, Shanghai Institute of Biochemistry and Cell Biology (CAS) Postdoctoral Fellow at Baylor College of Medicine (2009) Assistant Professor at VAI (2013–present) Research Interests: Dr. Yang’s lab explores: Sumoylation pathways in skeletal development and disease Epigenetic regulation of bone and cartilage health Stem cell-based therapies for tissue regeneration Link between aging and joint degeneration Lab Team & Impact: The Yang Lab includes postdoctoral fellows, research scientists, and graduate students. Recent work highlights include identifying ERV activation in osteoarthritis progression and uncovering roles for KDM5C in bone metabolism. Their research has contributed to clinical trials (e.g., VAI-SU2C Epigenetics Dream Team) and collaborations in drug development for skeletal disorders.

Feyza Enginمشاهده پروفایل

دانشیار

• Type 1 Diabetes
• Beta Cell Biology
• Endoplasmic Reticulum Stress
• +۳ مورد دیگر

Feyza Engin is an Associate Professor in the Department of Biomolecular Chemistry at the University of Wisconsin-Madison, affiliated with the School of Medicine and Public Health. Her research focuses on endoplasmic reticulum (ER) stress and its role in β-cell function and type 1 diabetes pathogenesis. Education: B.S. & M.S., Istanbul University, School of Pharmacy (1998–2001) Ph.D., Baylor College of Medicine (2007) Postdoctoral Fellowship, Harvard University (2013) Research Interests: The ER’s unfolded protein response (UPR) in β-cell survival during diabetes progression. Key areas include ER stress mechanisms, β-cell plasticity, and chemical interventions to mitigate diabetes. Her lab employs biochemical, genetic, and immunological tools to explore these pathways. Awards: NIH K01 Award (2014) JDRF Career Development Award (2014) Shaw Scientist Award (2016) Vilas Associate Award (2023) Labs/Teams: The Engin Lab investigates ER stress and β-cell dysfunction. Collaborates on diabetes heterogeneity studies and precision medicine approaches.

Zhongming Zhaoمشاهده پروفایل

استاد

• Bioinformatics
• Genomics
• Cancer Precision Medicine
• +۷ مورد دیگر

Zhongming Zhao, PhD, is a Professor and Chair at the McWilliams School of Biomedical Informatics at UTHealth Houston. He holds the Chair for Precision Health and directs the Center for Precision Health and the UTHealth Cancer Genomics Center. With over 25 years of experience, he specializes in bioinformatics, AI-driven healthcare solutions, and translational research. His work spans cancer genomics, pharmacogenomics, and neurodegenerative diseases. Dr. Zhao has authored over 550 papers, secured $190M in grants, and leads interdisciplinary teams in precision medicine. Education: PhD, Human and Molecular Genetics, University of Texas Health Science Center at Houston (2000) MS, Computer Science, University of Houston (2002) MS, Biomathematics, University of Texas Health Science Center (1998) MS, Genetics, Peking University (1996) BS, Biology, Zhejiang University (1991) Research Focus: Dr. Zhao’s expertise includes genomic sequencing technologies (WGS, RNA-Seq), single-cell omics, drug repositioning, and AI in healthcare. His lab develops computational tools like Deep5mC (DNA methylation prediction) and Dr. Kinase (drug resistance modeling). He investigates mechanisms of cancer immunotherapy resistance, neurodegenerative diseases, and psychiatric disorders through multi-omics integration. Awards: 2023 President’s Scholar Award Fellowships: ACMI, FAMIA, AIMBE Grants & Leadership: He oversees over 100 grants and collaborates with 100+ investigators. His leadership roles include Chief Bioinformatics Officer at Vanderbilt-Ingram Cancer Center and directorships in bioinformatics resources. Current initiatives focus on precision health, tumor microenvironment reprogramming, and AI-driven diagnostics. Labs & Teams: Leads the Center for Precision Health and collaborates across departments at UTHealth. His lab develops tools like deCS for single-cell annotations and ImmuneApp for immunopeptidome analysis. Active in translational projects like oncolytic virus therapies and drug repurposing for cancer and neurological diseases.

Tugba Ozdemirمشاهده پروفایل

استادیار

• Biomaterials
• Tissue Engineering
• Craniofacial Therapies
• +۱ مورد دیگر

Tugba Ozdemir is an Assistant Professor at the South Dakota School of Mines and Technology, leading the Extracellular Mimicry Laboratory. Her research focuses on developing biomimetic materials for craniofacial tissue regeneration, particularly bioactive hybrid polymers mimicking extracellular matrix functions. Her laboratory designs tunable biomaterial architectures using protein engineering and peptidomimetics to control cell fate and tissue organization. Key research areas include hyaluronic acid-based therapeutics, silk fibroin biomaterials, diabetic wound healing solutions, and anti-fibrotic strategies. Recent publications demonstrate consistent innovation in craniofacial biomaterials, with core themes in hyaluronic acid-peptide interactions, silk fibroin modifications, diabetic tissue response modulation, and educational STEM initiatives. Emerging focus includes antibacterial biofabrics and 3D cellular organization control.

Congzhou Wangمشاهده پروفایل

دانشیار

• Cancer Nanotherapeutics
• Cardiovascular Nanomaterials
• Nanoparticle-Cell Interactions
• +۳ مورد دیگر

Congzhou Wang is an Associate Professor in Nanoscience and Biomedical Engineering at South Dakota Mines. His research develops nanobiomaterials for cancer and cardiovascular disease treatment through biophysical modulation of cellular behavior. Research areas: Nanoparticle-mediated phenotype modulation in cancer and endothelial cells Targeted photothermal therapies using black phosphorus and gold nanomaterials Biocompatibility and biomechanical effects of metal-organic frameworks Actin cytoskeleton remodeling via nanomaterial interactions Publications demonstrate innovative approaches to reverse pathological cellular transitions (EMT/EndMT) using targeted nanosystems. Recent work focuses on N-cadherin targeting for atherosclerosis and CD146 targeting for metastatic cancer. Recipient of NSF CAREER Award and South Dakota Mines Research Award. Research supported by NIH, NASA, and NSF. Utilizes atomic force microscopy and molecular techniques to investigate nano-bio interactions.

• Mathematical Biology
• Genomics
• Bioinformatics
• +۳ مورد دیگر

Indika Rajapakse is a Professor of Mathematics and affiliated as a Professor of Computational Medicine and Bioinformatics at the University of Michigan. His primary affiliation is with the Department of Mathematics within the College of Literature, Science, and the Arts (LSA). He can be reached at indikar@umich.edu . Rajapakse’s research bridges mathematical theory and biomedical applications, focusing on genomic organization, hypergraph modeling, and computational methods for cell reprogramming and disease analysis. His research interests include mathematical biology , genomics , and systems biology , with a particular emphasis on understanding how genome architecture influences cellular identity and function. He develops tools like the 4DNvestigator and Bioinformatics Retrieval Augmentation Data (BRAD) system to analyze genomic and transcriptomic data. His work also explores machine learning applications in medicine, such as adversarial immune-inspired learning systems and language model integration in digital biology. Rajapakse’s publications highlight trends in hypergraph theory for biological networks, dynamic sensor selection for biomarkers, and computational platforms for medical research. He has contributed to studies on obesity-driven immune network disruptions, lineage-specific chromosomal topologies, and the role of macrophages in diabetes. His research often combines mathematical frameworks with experimental biology to address clinical and theoretical challenges. He advises students through the Mathematics department at U-M and collaborates on grants related to genome dynamics and computational medicine. Notable projects include developing the SEWAL platform for genomic data analysis and exploring the 4D Nucleome’s functional organization. Rajapakse’s interdisciplinary work advances both fundamental biology and translational medical research.

• Genetics
• Genomics
• Chromatin Biology
• +۲ مورد دیگر

Leonid Kruglyak is Professor and Chair of Human Genetics at UCLA's David Geffen School of Medicine, holding the Diller-von Furstenberg Family Endowed Chair. His laboratory investigates fundamental genetic mechanisms using model organisms including yeast, C. elegans, and human tissues. Research examines histone functions in biological processes and disease, chromatin biology, and genetic basis of complex traits. The lab employs biochemical, genetic, and high-throughput approaches to study gene regulation and genetic variation mechanisms. Honors include an endowed chair position recognizing contributions to genetic research. Research funding includes multiple NIH grants supporting studies of quantitative trait loci and complex trait genetics. Publications demonstrate expertise in developing novel genetic mapping techniques, characterizing genetic interactions, and evolutionary genetics across diverse model systems.

Lewis Cantleyمشاهده پروفایل

استاد

• Cancer Biology
• Cell Signaling
• Metabolism
• +۳ مورد دیگر

Lewis Cantley is a Professor of Cell Biology at Harvard Medical School (HMS) and a researcher at the Dana-Farber Cancer Institute. His work focuses on cell signaling, metabolism, and cancer biology. He is renowned for discovering the role of PI3 kinase in cancer and its implications for oncogenesis and cellular transformation. Cantley has held positions at HMS (1992-2003, 2022-present), the Systems Biology Department at HMS (2003-2012), and the Weill Cornell Meyer Cancer Center (2012-2022), where he led programs on cancer metabolism and signaling. His research interests include understanding how metabolic pathways and protein kinases regulate cancer progression, with particular emphasis on the interplay between signaling molecules like PI3K/AKT/mTOR and metabolic enzymes. Cantley has received continuous NIH funding for projects such as the 'Role of Phosphoinositides and Protein Kinases in Cancer Metabolism' and collaborations on cancer metabolism physics. Key publications highlight breakthroughs in glutamine dependency in pancreatic cancer, metabolic reprogramming in stem cells, and resistance mechanisms to kinase inhibitors. His work bridges fundamental biology with clinical applications, aiming to identify therapeutic targets in oncology. Affiliations: Harvard Medical School, Dana-Farber Cancer Institute Grants: NIH R35CA197588, U54CA210184, P01CA089021 Labs/Teams: Cancer Cell Biology Lab at Dana-Farber, interdisciplinary teams studying cancer metabolism

Karl Glastadمشاهده پروفایل

استادیار

• Aging Mechanisms
• Hormonal Signaling
• Epigenetics
• +۵ مورد دیگر

Karl Glastad is an Assistant Professor in the Department of Biology at the University of Rochester's School of Arts & Sciences. His research focuses on understanding the molecular mechanisms governing lifespan regulation, behavioral plasticity, and social caste determination in ants. He employs model systems such as Harpegnathos saltator and Camponotus floridanus to investigate epigenetic and hormonal pathways that underpin aging, stress responses, and caste-specific traits. Glastad's work combines experimental approaches like transgenic manipulation, neuronal culture studies, and in vivo ant research with interdisciplinary methods in molecular biology and genomics. Education: PhD (specific institution not listed). Current roles include accepting PhD students and postdoctoral researchers. His lab explores conserved and novel mechanisms of aging mitigation, blood-brain barrier regulation of behavior, and the evolutionary origins of social insect traits. Collaborations include work with Janko Gospocic and others on hormonal signaling pathways and epigenetic regulators such as HSF2 and CoREST. Key projects: Lifespan extension in reproductive ants, epigenetic disruption by SARS-CoV-2, and neurohormonal control of caste behavior. Methodologies: Transgenic manipulation, transcriptomic profiling, and comparative genomics. Future directions: Exploring convergent mechanisms in eusocial systems like termites and naked mole-rats.

Douglas S. Portmanمشاهده پروفایل

استاد

• Genetic Control of Sex Differences
• Neurobiology
• Behavioral Genetics
• +۳ مورد دیگر

Douglas S. Portman is a Professor at the University of Rochester, holding joint appointments in the Department of Biomedical Genetics, Department of Biology, and Department of Neuroscience. He leads the Portman Lab, which investigates how biological sex shapes neural circuit function and behavior using the C. elegans model. His work focuses on the genetic and molecular mechanisms underlying sex differences in neurobiology and disease susceptibility. Education: PhD in Molecular Biology and Genetics, University of Pennsylvania (1995) BA in Biochemistry with Honors, University of Pennsylvania (1988) Research Interests: Dr. Portman explores how biological sex influences neural development, behavior, and disease vulnerability. His lab uses C. elegans to study sex-specific modulation of sensory circuits, decision-making, and behavioral prioritization. Key topics include the genetic control of sexual dimorphism, metabolomic differences between sexes, and the role of non-coding RNAs in developmental timing. Recent Trends in Publications: Recent work highlights sex-specific responses to sensory cues, the role of PDFR-1 in pheromone avoidance, and the impact of food abundance on foraging behavior. Studies also reveal how neural circuits are reprogrammed to shape sexual behavior and how non-coding RNAs regulate developmental transitions. Awards: 2025 Peter Shrager Award for Service to the Rochester Neuroscience Community NIGMS R35 MIRA Award (NIH) Advising & Grants: Current advisees include graduate students Xi Kuang, Ryan Zhang, and Zack Ward, and undergrad Ember Johnson. His lab has secured funding from NIH for studies on neuroendocrine and neurodevelopmental disorders in C. elegans . Collaborations involve researchers in genetics, neuroscience, and metabolomics. Labs/Teams: The Portman Lab is part of the Del Monte Institute for Neuroscience and the Center for Neurotherapeutics Discovery at URMC. Research focuses on integrating genetic, cellular, and behavioral approaches to understand sex-based neural plasticity.

Timothy Downingمشاهده پروفایل

دانشیار

• Stem Cell Engineering
• Regenerative Biology
• Epigenomics
• +۴ مورد دیگر

Timothy Downing, Ph.D., is an Associate Professor in the Department of Biomedical Engineering at the University of California, Irvine (UCI). He leads the Downing Lab, affiliated with UCI's Department of Microbiology and Molecular Genetics, Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC), and the NSF-Simons Center for Multiscale Cell Fate Research (CMCF). His research focuses on epigenetic regulation, mechanobiology, and regenerative engineering. The lab develops molecular tools and biomaterials to control cell fate through synthetic epigenome modulation, with applications in heart regeneration, tissue longevity, and cancer research. Key research themes include understanding epigenetic changes during development and disease, particularly via non-sequence DNA modifications. The lab integrates biophysical cues with molecular mechanisms to engineer cells and tissues, emphasizing biomaterial design and systems biology approaches. Downing's work bridges fundamental science and translational medicine, addressing challenges in regenerative therapies and disease modeling. His recent articles highlight advancements in chromatin structure modeling, DNA methylation dynamics, and mechanosensitive therapies. Collaborations span biomaterials engineering, immunology, and genetic disorders. The Downing Lab is located in the Core Lab on the 6th floor of ISEB, reflecting its interdisciplinary focus.

Wendy Liuمشاهده پروفایل

استاد

• Biomaterials
• Cell and Tissue Engineering
• Mechanotransduction
• +۴ مورد دیگر

Wendy Liu is a Professor in the Department of Biomedical Engineering at the University of California, Irvine (UCI), affiliated with The Henry Samueli School of Engineering. Her laboratory focuses on developing bioinspired materials to modulate immune responses and engineer functional biomaterials for tissue regeneration. Key areas include biomaterials design, mechanotransduction, and macrophage biology. Research emphasizes understanding how cellular microenvironments influence immune cell behavior, with applications in wound healing, cardiovascular systems, and medical device integration. Her interdisciplinary approach combines microfabrication, protein engineering, and high-throughput screening to create materials that mimic physiological environments. Recent work highlights modulation of macrophage phenotype via mechanical cues (e.g., stiffness, topography) and biomaterial surface modifications. Notable projects include CD200-releasing hydrogels to suppress inflammation and co-culture systems for cartilage regeneration. Students advised include Jessica Schlosser (MS), Jessica Hsieh (PhD), and Thuy (awarded a CIRM training grant). Recent lab milestones: new postdoc Dr. Vijay Meli, FDA appointment for Dr. Frances McWhorter, and MS graduate Jessica Schlosser. Labs/Teams: Liu Lab (UCI), with collaborations on biomaterials and immunology.

Dongbao Chenمشاهده پروفایل

استاد

• Reactive nitrogen/sulfide species
• Nitrosylation
• Sulfhydration
• +۸ مورد دیگر

Dr. Dongbao Chen is a Professor in the Department of Obstetrics and Gynecology at the University of California, Irvine School of Medicine. His research focuses on the roles of reactive nitrogen/sulfide species in reproductive and vascular physiology, particularly during pregnancy. Dr. Chen’s work integrates molecular biology, proteomics, and cellular models to explore mechanisms underlying preeclampsia, placental dysfunction, and vascular malformations such as port-wine birthmarks. Key research topics include estrogen-mediated regulation of hydrogen sulfide (H2S) biosynthesis in uterine and placental vasculature, nitrosylation and sulfhydration signaling pathways, and the interplay between hormonal factors and vascular adaptations. His studies leverage animal models, patient-derived induced pluripotent stem cells (iPSCs), and proteomic platforms to uncover novel therapeutic targets and biomarkers for pregnancy complications and vascular disorders. Recent work highlights H2S’s role in mitigating hypertension in pregnancy and vascular dysfunction, as well as the metabolic and signaling perturbations in port-wine birthmark-derived endothelial cells. Dr. Chen’s publications often bridge basic science and clinical applications, emphasizing translational insights into maternal-fetal health and vascular biology.