معرفی
Dr. Dongbao Chen is a Professor in the Department of Obstetrics and Gynecology at the University of California, Irvine School of Medicine. His research focuses on the roles of reactive nitrogen/sulfide species in reproductive and vascular physiology, particularly during pregnancy. Dr. Chen’s work integrates molecular biology, proteomics, and cellular models to explore mechanisms underlying preeclampsia, placental dysfunction, and vascular malformations such as port-wine birthmarks.
Key research topics include estrogen-mediated regulation of hydrogen sulfide (H2S) biosynthesis in uterine and placental vasculature, nitrosylation and sulfhydration signaling pathways, and the interplay between hormonal factors and vascular adaptations. His studies leverage animal models, patient-derived induced pluripotent stem cells (iPSCs), and proteomic platforms to uncover novel therapeutic targets and biomarkers for pregnancy complications and vascular disorders.
Recent work highlights H2S’s role in mitigating hypertension in pregnancy and vascular dysfunction, as well as the metabolic and signaling perturbations in port-wine birthmark-derived endothelial cells. Dr. Chen’s publications often bridge basic science and clinical applications, emphasizing translational insights into maternal-fetal health and vascular biology.
