Andrei Goga

Andrei Goga, MD, PhD is a Professor in the Department of Cell and Tissue Biology at the University of California San Francisco (UCSF) School of Medicine. His research focuses on understanding how oncogenes like MYC drive tumorigenesis through cell cycle, miRNA, and metabolic signaling pathways. The Goga Lab investigates therapeutic strategies targeting MYC-driven cancers, including triple-negative breast cancer and liver malignancies. Recent work highlights tumor microenvironment interactions, immune evasion mechanisms, and drug resistance pathways.

Key research areas include:

• MYC oncogene biology and synthetic-lethal interactions
• Metastasis mechanisms and tumor plasticity
• Mitochondrial metabolism in cancer progression
• Combination immunotherapy strategies

Publications highlight breakthroughs in understanding microbiota-drug interactions, mitochondrial reprogramming, and single-cell analysis of metastatic progression. Ongoing clinical trials evaluate novel therapies targeting cancer metabolism and immune checkpoints.

Laboratory facilities include advanced metabolic imaging capabilities and collaboration with the UCSF Helen Diller Family Comprehensive Cancer Center. Current projects focus on translating molecular discoveries into clinical applications for hard-to-treat cancers.