Dr. Trevor Shepherd is an Associate Professor cross-appointed in Obstetrics & Gynecology, Oncology, and Anatomy & Cell Biology at Western University. His lab focuses on ovarian cancer metastasis mechanisms within the Translational Ovarian Cancer Research Program. Research examines molecular pathways in ascites-derived spheroid models, including LKB1-mediated stress signaling, autophagy survival mechanisms, and EMT plasticity. Key research areas: Bioenergetic stress signaling in metastatic niches Therapeutic autophagy inhibition strategies Regulation of epithelial-mesenchymal plasticity Oncolytic virus efficacy in heterogeneous tumors Shepherd's publications span ovarian cancer models, spheroid biology, and therapeutic targeting. Recent studies demonstrate advancements in understanding AKT-mediated dormancy and ROS-dependent drug effects. His laboratory employs three-dimensional culture systems and patient-derived models to study transcoelomic metastasis. Collaborative projects include biomarker discovery and preclinical therapeutic testing.










