جست‌وجوی استاد و پژوهشگر

Ursula Jakobمشاهده پروفایل

استاد

• Oxidative Stress
• Aging Mechanisms
• Microbial Defense
• +۳ مورد دیگر

Ursula Jakob is the Patricia S. Yaeger Collegiate Professor in the Department of Molecular, Cellular, and Developmental Biology (MCDB) at the University of Michigan. She holds a B.S. (1991) and Ph.D. (1995) from Regensburg University, Germany. After postdoctoral research at the University of Michigan and roles as an Assistant Research Scientist, she joined the faculty in 2001. Her research focuses on oxidative stress, aging mechanisms, and microbial defense, with particular interest in how oxidants influence host defense and longevity. Her lab explores molecular chaperones like Hsp33 and investigates polyphosphate’s role in cellular processes. Jakob has been recognized with awards including the Burroughs Wellcome Fund Career Award and election to the Bavarian Academy of Sciences. Education and Career Path: B.S. and Ph.D. from Regensburg University (Germany), followed by postdoctoral training at UM and faculty appointment since 2001. She leads the Jakob Lab, which studies redox regulation, protein folding, and aging. Key contributions include discoveries about bleach’s antimicrobial effects and the role of early-life oxidants in lifespan determination. Research Interests: Molecular mechanisms of oxidative stress defense, redox regulation in aging, polyphosphate’s multifunctional roles, and protein chaperone dynamics. Her work bridges basic science and translational applications, such as developing therapies to combat microbial infections and age-related diseases. Awards and Honors: Biomedical Career Award (2000), UM Faculty Recognition Award, Bavarian Academy membership (2014), and UM Biological Scholar designation.

• Neurobiology
• Neurodegenerative Diseases
• RNA Splicing
• +۷ مورد دیگر

Sarah Kargbo-Hill is an Assistant Professor in the Department of Molecular, Cellular, and Developmental Biology (MCDB) at the University of Michigan. She joined the department in January 2024 and leads the Kargbo-Hill Lab, which investigates neuronal longevity mechanisms under stress and aging. Her work focuses on epigenomic and transcriptomic adaptations, particularly RNA splicing and DNA methylation in neurodegenerative diseases like ALS. Education: Ph.D. in Cell Biology from Yale University (lab of Dr. Daniel Colón-Ramos), B.S. in Biology from Penn State University (lab of Dr. Melissa Rolls). Postdoctoral research at Dr. Michael Ward’s lab explored TDP-43-linked proteins in human iPSC-derived neurons. Research interests include neuronal resilience, autophagy regulation, synaptic biology, and how aging impacts gene expression programs. Her lab uses multi-omics approaches and model systems like C. elegans and human iPSC neurons to study these processes. Key findings include mechanisms of TDP-43-driven ALS pathology, autophagosome maturation, and DNA repair in neurons. Recent work highlights links between RNA splicing defects and neurodegenerative biomarkers. Labs/Teams: Principal Investigator of the Kargbo-Hill Lab in the Biological Sciences Building, Ann Arbor. Collaborates with neurodegeneration research networks and employs advanced microscopy and genomic tools.

Stuart Firesteinمشاهده پروفایل

استاد

• Olfaction
• Signal Transduction
• Neurogenesis
• +۳ مورد دیگر

Stuart Firestein serves as Professor of Biological Sciences and Provost's Senior Faculty Teaching Scholar at Columbia University. His laboratory investigates cellular mechanisms of signal transduction and olfaction, using vertebrate olfactory receptor neurons as models to study receptor-ligand interactions, second messenger modulation, ion channel gating, and adaptation mechanisms. The research employs adenovirus vectors to overexpress cloned odor receptors, enabling study of ligand-binding affinities and structure-function relationships in G-protein coupled receptors. Firestein's work examines the unique regenerative capacity of olfactory neurons, quantifying biophysical parameters in developing neurons through physiological techniques. His interdisciplinary approach combines electrophysiology, molecular biology, immunohistochemistry, and anatomical methods to address fundamental questions about olfactory coding and neuronal development. His publications demonstrate sustained focus on olfactory neurobiology, with recent work exploring neurogenesis, cortical organization, and the role of olfactory receptors in systemic physiology. The research has expanded to include microbial interactions with host physiology and advanced imaging techniques for protein structure analysis.

• Vascular Biology
• Cellular Signaling
• Metabolic Regulation
• +۳ مورد دیگر

Dr. Nathalie Tisch is a Lecturer at the Department of Health Sciences and Technology at ETH Zürich. Her research focuses on vascular biology, cellular signaling, and metabolic regulation. She investigates endothelial cell functions in contexts such as angiogenesis, inflammation, and neurovascular development. Key projects include studying the roles of caspase-8, Tie receptors, and metabolic pathways in health and disease. Her work employs mouse models and interdisciplinary approaches to understand vascular dynamics and pathophysiological mechanisms. Her research interests span multiple disciplines, including cell death signaling, inflammatory processes, and developmental biology. She has contributed to understanding how endothelial cells interact with macrophages, regulate insulin sensitivity, and respond to genetic mutations like PIK3CA. Her studies also address malaria parasite behavior and biomechanical sensing during transmission. Dr. Tisch’s articles highlight advancements in understanding vascular homeostasis, neurovascular coupling, and the molecular mechanisms underlying blood vessel formation. Despite no explicit mention of awards, grants, or labs in the provided texts, her extensive publication record reflects active engagement in cutting-edge vascular research. She advises no listed students but contributes to academic training through her lecturing role.

Yong-Ling Ruanمشاهده پروفایل

استاد

• Plant Biology
• Carbon Allocation
• Sugar Signaling
• +۴ مورد دیگر

Prof Yong-Ling Ruan is an Honorary Group Leader in the Division of Plant Sciences at The Australian National University. His research focuses on understanding carbon nutrient allocation, sugar metabolism, and signaling to enhance crop yield and resilience. He leads studies on plant developmental processes, stress responses, and molecular networks governing resource distribution during evolution and domestication. Education: Holds BS, MS, and PhD qualifications (exact institutions unspecified). Research interests include carbon allocation for eco-health, sugar signaling in growth/stress responses, and molecular networks in resource partitioning. Notable contributions include the 'Ready-Set-Grow' model for seed/fruit set and discoveries in sugar transport/transporter roles in stress tolerance. Key achievements: Published in top journals (Plant Cell, Nature Plants, Molecular Plant), with an h-index of 56 (Google Scholar). Awards include the Peter Goldacre Medal (ASPS) and NSFC Distinguished Young Scientist Award. Served on ARC College of Experts and editorial boards, including Molecular Plant and The Plant Cell. Grants/Projects: Directed the Australian-China Research Centre for Crop Improvement (2018-2021). Current project: Improving plant reproductive success under heat stress (2018-2024). Focus areas include cell wall invertase roles, heat stress transcriptional regulation, and drought resistance mechanisms. Labs/Teams: Collaborates globally on carbon partitioning, sugar transporters, and stress biology. Active in editorial roles and international research networks.

• Clinical Genomics
• Genetic Disorders
• Mitochondrial Biology
• +۳ مورد دیگر

Emma Jenkinson is a Lecturer in Clinical Genomics at the Division of Evolution, Infection and Genomics, The University of Manchester. Her research focuses on genetic disorders, mitochondrial biology, and molecular mechanisms underlying neurological and developmental conditions. She has contributed to understanding genetic variants linked to leukoencephalopathy, Perrault syndrome, and interferonopathies through interdisciplinary approaches combining clinical genetics, zebrafish models, and genomic analysis. Her work aligns with UN Sustainable Development Goals related to health and well-being. Education: Completed a thesis on 'The Genes Involved in Hearing and Endocrine Disorders' in 2012, supervised by Professors Davis and Newman at the same institution. Research Interests: Emma’s expertise spans clinical genomics, mitochondrial dysfunction, and genetic mutations in rare neurological disorders. She employs zebrafish models to study RNA processing defects and their impact on human disease. Her studies often integrate genetic sequencing, functional assays, and clinical correlations to uncover pathogenic mechanisms. Collaborations: Active in international collaborations, including the Deciphering Developmental Disorders (DDD) Study, focusing on undiagnosed genetic conditions. Her network includes researchers across Europe and the U.S. in neurology, immunology, and developmental biology. Labs/Teams: Engaged in multidisciplinary teams within the Division of Evolution, Infection and Genomics, specializing in translational genomics and rare disease research. She contributes to initiatives bridging basic science and clinical applications.

Larisa Labzinمشاهده پروفایل

پژوهشگر ارشد

• Innate Immunity
• Immunology
• Virology
• +۴ مورد دیگر

Dr. Larisa Labzin is an ARC Future Fellow at the Institute for Molecular Bioscience (IMB), University of Queensland. Her research focuses on innate immune sensing of viral infections and inflammatory responses. She holds a PhD from the University of Bonn and conducted postdoctoral research at the MRC Laboratory of Molecular Biology (Cambridge, UK). Her work spans viral pathogenesis, cytokine signaling, and SARS-CoV-2 biology. Key achievements include discovering novel anti-inflammatory pathways and mechanisms of antibody-dependent enhancement. Research Interests: Innate immunity, viral sensing, inflammasome activation, cytokine networks, and pandemic-related inflammation. Current projects investigate how macrophages detect viral threats and regulate immune responses to influenza and SARS-CoV-2. Articles highlight her contributions to understanding post-acute SARS-CoV-2 sequelae, ACE2-dependent viral replication in macrophages, and hyaluronic acid’s role in vascular diseases. Awards include the NHMRC CJ Martin Fellowship and ARC Future Fellowship.

Tak Makمشاهده پروفایل

استاد

• Cancer Biology
• Immunology
• Apoptosis Signaling
• +۳ مورد دیگر

Professor Tak Mak is a renowned academic at the University of Toronto, affiliated with the Campbell Family Institute for Breast Cancer Research at the Princess Margaret Cancer Centre. His work focuses on cancer biology, immunology, and apoptosis mechanisms, with a strong emphasis on genetic engineering and mouse models to study disease processes. He holds a PhD from the University of Alberta and has dedicated his career to understanding immune system functions, tumor development, and DNA repair pathways. Key research areas include the role of PTEN, p53, and other tumor suppressor genes in cancer progression, as well as the signaling pathways governing programmed cell death. His publications highlight breakthroughs in understanding FADD, caspases, and Apaf-1 in apoptosis regulation, as well as the development of imaging techniques for breast cancer diagnosis. Recent work has explored DJ-1’s role in PTEN modulation and RhoC’s metastatic function. Mak’s research has advanced cancer therapy strategies and provided foundational insights into immune system biology. His lab continues to investigate novel therapeutic targets through genetic and computational approaches.

• Machine Learning
• Statistics
• Neuroscience
• +۴ مورد دیگر

Josue Orellana is a Research Professor in the Department of Statistics & Data Science at Carnegie Mellon University (CMU) and serves as Managing Editor of the Computational Neuroscience Navigator initiative. He holds a PhD in Machine Learning and Neural Computation from CMU (2019) and a B.S. in Electrical Engineering from Washington State University. Previously, he worked as a Research Scientist at the National University of Singapore and Johns Hopkins University. His research integrates Statistics , Machine Learning , and Computational Neuroscience to model brain network interactions during cognitive tasks. He also investigates statistics education methodologies through the CMU Teach Stat research group. His work emphasizes graphical network analysis, phase coupling in neural circuits, and educational cognitive science. Publications span neuroscience, machine learning, and statistics education, with recent articles exploring neural oscillations, educational assessment tools, and multivariate phase coupling. His scholarly output demonstrates consistent focus on statistical methodology in neural systems and innovations in STEM pedagogy . Awards & Grants: CMU Simon Seed Grant (2020) GuSH cross-walk statistics education grant (2019) CMU Presidential Fellowship (2016-2018) President’s Honor Roll, WSU (2008-2012) He leads the Computational Neuroscience Navigator project at CMU’s Open Learning Initiative, developing concept-driven video resources. No advising relationships or lab affiliations are detailed beyond his educational research group.

• Membrane Biology
• Cellular Physiology
• Inflammatory Response
• +۳ مورد دیگر

Juan C. Sáez is a Visiting Professor at the Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine. His research focuses on membrane channels (gap junctions and hemichannels) composed of connexins and pannexins, with emphasis on their roles in physiological and pathophysiological processes, particularly inflammation. He investigates how hemichannel opening contributes to tissue dysfunction in chronic inflammatory diseases and seeks therapeutic blockers for these conditions. Key research areas include the regulation of Cx43 and Pannexin-1 channels in endothelial dysfunction, mast cell degranulation, skeletal muscle pathology, and neurodegenerative diseases like Alzheimer’s. He employs primary cells from nervous/immune systems and exogenous expression systems to study channel dynamics under stress, inflammation, and metabolic disorders (e.g., high glucose conditions). His recent work highlights the role of pannexin channels in immune cell migration (dendritic cells) and the impact of glucocorticoids on oligodendrocyte inflammasomes. Collaborations span muscle biology (skeletal myofiber apoptosis in dystrophy models) and stress-induced neuroinflammation (hippocampal glial/neuronal hemichannel activation). Publications emphasize mechanistic insights into channelopathies and translational efforts toward anti-inflammatory therapies. Current projects aim to develop selective channel blockers targeting chronic inflammatory diseases.

Steven C. Almoمشاهده پروفایل

استاد

• Biochemistry
• Structural Biology
• Immunology
• +۸ مورد دیگر

Steven C. Almo is a Professor and Chair of the Department of Biochemistry at Albert Einstein College of Medicine. He holds the Wollowick Family Foundation Chair in Multiple Sclerosis and Immunology, and directs the Einstein Macromolecular Therapeutics Developmental Facility. He also serves as Co-Leader of the Cancer Therapeutics Program at the Montefiore Einstein Comprehensive Cancer Center. His research focuses on high-throughput strategies for exploring biological function using automation and robotics. This includes large-scale enzyme function annotation to understand the gut microbiome's role in human health, industrial chemical processes, and environmental nutrient cycles. His work on immune system structural biology has advanced understanding of molecular mechanisms controlling immunity, informing treatments for infectious diseases, autoimmune disorders, and cancers. His research interests emphasize structural and functional analysis of immune receptors (e.g., HVEM, FasL, TIGIT), cancer immunotherapy via immune checkpoint inhibitors, and metabolite discovery. The lab also develops protein production methods in Drosophila S2 cells for structural studies. Collaborations span multiple institutions including Montefiore Einstein, with projects addressing viral defenses encoded in the human genome and nuclear pore complex components. While no explicit scientific awards are listed, his contributions to structural biology and biomedical technology are evident through his publications and leadership roles. His advising and grants are not detailed here, though his lab's infrastructure suggests substantial funding. Key facilities include the Einstein Macromolecular Therapeutics Developmental Facility, which supports large-scale therapeutic development.

• Immunology
• Virology
• Cell Signaling
• +۲ مورد دیگر

Dr. Cheung Ching For Peter is a Senior Lecturer at the School of Biological Sciences, Nanyang Technological University (NTU), Singapore. His research focuses on immunology, virology, and cell signaling pathways with significant contributions to understanding molecular mechanisms of immune responses. Dr. Cheung received his academic training in the United Kingdom: BSc in Biochemistry from Cardiff University, UK PhD in Biochemistry from Imperial College, University of London, UK His research interests span several areas of molecular and cellular biology with a particular focus on immune system signaling pathways. Dr. Cheung's work has contributed to our understanding of: Interferon signaling pathways in viral infections TAK1 kinase in innate immunity and cell signaling Ubiquitination processes in immune regulation Cellular responses to oxidative stress Dr. Cheung has published several significant papers in reputable journals including PLoS ONE, Journal of Biological Chemistry, and IUBMB Life. His recent work (2011-2013) has primarily focused on the molecular mechanisms of immune responses, particularly examining how cells respond to viral infections and regulate inflammatory pathways through proteins like TAK1 and Pellino1. As a Senior Lecturer at NTU, Dr. Cheung is actively involved in teaching and research at the School of Biological Sciences, where he contributes to the education of undergraduate and graduate students in biochemistry and related fields.

Pavak Kirit Shahمشاهده پروفایل

استادیار

• Developmental Biology
• Cell Lineage Tracking
• C. elegans Genetics
• +۵ مورد دیگر

Pavak Kirit Shah is an Assistant Professor in the Department of Molecular, Cell and Developmental Biology at the University of California, Los Angeles (UCLA), within the College of Letters and Science. His research focuses on understanding developmental mechanisms, particularly in neuronal patterning and cell lineage dynamics in Caenorhabditis elegans . Dr. Shah's research interests include: Developmental biology of Caenorhabditis elegans Cell lineage tracking and reconstruction Computational approaches to developmental biology Microscopy and imaging techniques for developmental studies Neuronal patterning and robustness mechanisms Immune cell biomechanics His recent publications demonstrate a strong focus on developing and applying advanced imaging and computational techniques to study developmental processes. His work bridges developmental biology, computational analysis, and advanced microscopy, with an expanding interest in the biomechanics of immune cell interactions. Dr. Shah's lab has pioneered innovative approaches for automated cell lineage reconstruction and topographical profiling of cellular interactions, contributing significantly to understanding developmental robustness. Dr. Shah has been awarded NIH funding for his research: R00HD096050: "Understanding the Developmental Mechanisms that Ensure Robustness in Neuronal Patterning" (2019-2022) K99HD096050: "Understanding the developmental mechanisms that ensure robustness in neuronal patterning" (2018-2020) His collaborative work extends across multiple disciplines, with publications spanning developmental biology, immunology, and computational biology. Dr. Shah maintains active collaborations with researchers at UCLA and other institutions, particularly in the areas of C. elegans development and immune cell mechanics.

Euisik Yoonمشاهده پروفایل

استاد

• Bio-MEMS
• Microfluidics
• Bio-Nanotechnology
• +۶ مورد دیگر

Euisik Yoon is a **Professor of Electrical Engineering & Computer Science** at the **University of Michigan**'s **College of Engineering**. His research focuses on **Bio-MEMS, Microfluidics, Neural Engineering, and Cancer Treatment Technologies**, with a lab dedicated to developing advanced microsystems for neuroscience and biomedical applications. He leads the **Yoon Lab**, which innovates in neural probes, optogenetic interfaces, and single-cell analysis platforms. Key achievements include the **Monroe-Brown Foundation Research Excellence Award (2023)** and the **Best Paper Award at IEEE BIOCAS 2022**. His work spans **neural recording systems**, **microLED-based optoelectrodes**, and **high-throughput cancer cell analysis** techniques like **Hydro-Seq** and **MiniSTAR**. Collaborations with clinicians and engineers have produced breakthroughs in **brain-machine interfaces**, **prostate cancer diagnostics**, and **metastasis research**. Notable projects include **self-assembled origami neural probes**, **ultra-compliant carbon nanotube devices**, and **scalable optogenetic tools** for studying neural networks in vivo. His lab also develops **3D-printed electrophysiology systems** and **low-power biomedical sensors**. Key Awards: Monroe-Brown Award, PCF Challenge Award, Nature Communications Publications Research Themes: Neural interfaces, cancer diagnostics, optogenetics, microfluidics Lab Innovations: Yoon Lab designs bio-inspired sensors, neural probes, and cancer analysis platforms

Viki Allanمشاهده پروفایل

استاد

• Cell Biology
• Molecular Biology
• Neuroscience
• +۴ مورد دیگر

Viki Allan is a Professor of Cell Biology at the University of Manchester , specializing in microtubule motor proteins and their roles in cellular dynamics and disease. Her work bridges fundamental cell biology with pathological implications, particularly in neurodegeneration and cancer. Education: B.Sc. in Biochemistry and D.Phil. in Cell Biology from the University of York Postdoctoral training: European Molecular Biology Laboratory (Heidelberg), Ron Vale Lab (UCSF) Her research investigates the regulation and function of molecular motors (dynein, kinesin) in membrane traffic , cell division , and neurodegenerative diseases . She pioneered cell-free systems to analyze motor-cargo interactions and discovered kinesin light chain isoforms' role in membrane specificity. Recent publications focus on C. elegans models for vesicle transport, mathematical modeling of endosomal aging, and LINC complex in infertility. Her lab employs advanced microscopy and molecular techniques to study spatial-temporal coordination of cellular processes. Scientific Awards : Lister Institute Senior Research Fellow Allan actively engages in teaching, delivering lectures on cell biology and designing practical courses for students. She contributes to the UN Sustainable Development Goals through Dementia@Manchester research.