Steven C. Almo

Steven C. Almo is a Professor and Chair of the Department of Biochemistry at Albert Einstein College of Medicine. He holds the Wollowick Family Foundation Chair in Multiple Sclerosis and Immunology, and directs the Einstein Macromolecular Therapeutics Developmental Facility. He also serves as Co-Leader of the Cancer Therapeutics Program at the Montefiore Einstein Comprehensive Cancer Center. His research focuses on high-throughput strategies for exploring biological function using automation and robotics. This includes large-scale enzyme function annotation to understand the gut microbiome's role in human health, industrial chemical processes, and environmental nutrient cycles. His work on immune system structural biology has advanced understanding of molecular mechanisms controlling immunity, informing treatments for infectious diseases, autoimmune disorders, and cancers.

His research interests emphasize structural and functional analysis of immune receptors (e.g., HVEM, FasL, TIGIT), cancer immunotherapy via immune checkpoint inhibitors, and metabolite discovery. The lab also develops protein production methods in Drosophila S2 cells for structural studies. Collaborations span multiple institutions including Montefiore Einstein, with projects addressing viral defenses encoded in the human genome and nuclear pore complex components.

While no explicit scientific awards are listed, his contributions to structural biology and biomedical technology are evident through his publications and leadership roles. His advising and grants are not detailed here, though his lab's infrastructure suggests substantial funding. Key facilities include the Einstein Macromolecular Therapeutics Developmental Facility, which supports large-scale therapeutic development.