جست‌وجوی استاد و پژوهشگر

• Rheumatology
• Immunology
• Autoimmune Diseases
• +۲ مورد دیگر

Dr. Lingli Dong serves as Director, Professor, and Chief Physician in the Department of Rheumatology and Immunology at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology in Wuhan, China, where she also supervises PhD candidates. Her leadership spans clinical care, academic instruction, and research direction within this major medical institution. Her research program centers on autoimmune pathologies including rheumatoid arthritis, psoriasis, Sjögren's syndrome, and IgG4-related disease, with particular emphasis on pandemic response mechanisms and molecular disease pathways. Through clinical investigations and multi-omics approaches, she examines viral interactions with autoimmune conditions, cellular immunology in connective tissue disorders, and therapeutic safety profiles—translating laboratory findings into improved patient management strategies for complex rheumatic diseases. Analysis of Dr. Dong's 2020-2021 publications reveals dominant themes in pandemic-era rheumatology, featuring eight high-impact studies originating from Hubei province. Her work demonstrates methodological diversity spanning multicenter observational cohorts, molecular pathway analyses, and digital health innovations, with recurring focus on SARS-CoV-2 interactions with autoimmune conditions, NK cell dysregulation in Sjögren's syndrome, and IL-33-mediated psoriasis mechanisms—all contributing to evidence-based clinical guidelines during global health crises. As an academic leader, Dr. Dong mentors graduate researchers while serving the scholarly community through editorial roles including Review Editor for B Cell Biology in Frontiers in Immunology and Rheumatology section editor at Frontiers in Medicine, facilitating critical discourse in immunological and rheumatological research. Within Tongji Hospital's infrastructure, she integrates clinical practice with research innovation through the Department of Rheumatology and Immunology, directing patient-centered investigations that address urgent questions in autoimmune disease management during public health emergencies while advancing fundamental understanding of disease pathogenesis.

Thomas Leonardمشاهده پروفایل

استاد

• Lipid signaling
• Protein kinases
• Signal transduction
• +۵ مورد دیگر

Thomas Leonard is a tenured Professor at the Max Perutz Labs (University of Vienna), where he leads a research group focused on lipid-mediated signal transduction and structural mechanisms of kinase regulation . His lab combines structural biology , biochemistry , and cell biology to dissect how cells integrate spatial and temporal signals. PhD in Structural Biology (MRC Laboratory of Molecular Biology, Cambridge) Postdoctoral work at NIH, Bethesda His research explores how lipid second messengers like PIP3 and PI3P control kinases such as Akt, PDK1, and Sgk3, with implications for cancer , neurodevelopmental disorders , and metabolic diseases . Recent work redefined PHLPP1/2 as pseudophosphatases and revealed novel activation mechanisms in Protein Kinase D (PKD) and DMPK kinases. The lab's publication trends highlight structural phylogenomics , membrane scaffolding , and allosteric regulation . Collaborations with institutions like LMU Munich and FWF-funded projects underscore their interdisciplinary approach. Lab Manager: Ronja Reinhardt PhD Students: Sumire Antonioli, Magdalena Otto, Lucas Piech, Eva Krotenheerdt, Felix Wolkenstein Master Students: Gabriela Ariza, Emese Galgóczi, Stefan Lenz The lab actively recruits at Master, PhD, and Postdoc levels for molecular signaling research.

Zalfa Abdel-Malekمشاهده پروفایل

استاد

• Melanocyte Biology
• UV Radiation Response
• Melanoma Prevention
• +۴ مورد دیگر

Zalfa Abdel-Malek is a distinguished Professor in the Department of Environmental Health at the University of Cincinnati College of Medicine, where she has maintained an active research program for over two decades. Her work bridges dermatology, molecular biology, and environmental health, focusing on the mechanisms of skin pigmentation and melanoma development. Her educational background includes a Bachelor's degree in Biology from the American University of Beirut (1974), followed by Master's (1980) and Doctoral degrees (1984) in General Biology from the University of Arizona. She completed postdoctoral training in Dermatology at the University of Cincinnati in 1987, establishing her long-standing relationship with the institution. Dr. Abdel-Malek's research centers on the melanocortin 1 receptor (MC1R) and its role in regulating cutaneous pigmentation and the response to UV radiation. She pioneered work demonstrating that human melanocytes express functional MC1R and that activation of this receptor is critical for the tanning response to UV. Her laboratory discovered that activated MC1R enhances the repair of UV-induced DNA damage, maintaining genomic stability of melanocytes and preventing malignant transformation to melanoma. This work has led to the development of small peptide analogs of α-MSH that could potentially serve as topical agents for melanoma prevention. Analysis of her recent publications reveals a consistent focus on MC1R signaling pathways, DNA repair mechanisms in melanocytes, and the development of melanocortin-based therapeutics for melanoma prevention. Her work increasingly explores the tumor microenvironment, genetic interactions between MC1R variants and other melanoma susceptibility genes, and translational applications of basic research findings. Vitiligo Research Award (1990) from the PanAmerican Society for Pigment Cell Research Aaron B. Lerner Award (2006) from the PanAmerican Society for Pigment Cell Research Myron Gordon Award (2011) from the International Federation for Pigment Cell Societies Dr. Abdel-Malek has secured continuous funding as Principal Investigator on numerous NIH grants, including multiple R01 awards from NIEHS and NCI, as well as funding from the Department of Defense and industry partners. Her current research program includes testing small peptide analogs of α-MSH for melanoma prevention, investigating the impact of MC1R variants on DNA damage response, and exploring novel paradigms in melanoma prevention. She maintains active collaborations with researchers across multiple institutions, particularly with Ana Luisa Kadekaro and other colleagues at the University of Cincinnati.

Zeynep Erson Omayمشاهده پروفایل

استادیار

• Computational Biology
• Genomics
• Epigenomics
• +۶ مورد دیگر

Dr. Zeynep Erson Omay serves as an Assistant Professor in the Department of Neurosurgery and Biomedical Informatics & Data Science at Yale School of Medicine. Her work bridges computational biology with neurosurgical oncology, focusing on precision medicine applications for brain tumors, with particular emphasis on understanding tumor heterogeneity and molecular mechanisms of CNS tumors. Dr. Erson Omay's educational background includes: PhD in Computer Science from Case Western Reserve University (2011) MS in Computer Science from Bilkent University (2005) BS in Computer Science from Bilkent University (2003) Her research focuses on computational analysis of multi-omic datasets to understand tumor heterogeneity, particularly in central nervous system tumors. Dr. Erson Omay specializes in genomic, transcriptomic, and epigenetic profiling of brain tumors, with emphasis on meningiomas, glioblastomas, and rare CNS tumor subtypes. She leads the Erson Lab, which develops bioinformatics approaches to study large datasets and reveal molecular mechanisms in tumor formation, progression, and clinical outlier subgroups. Her work in precision medicine aims to decipher the molecular architecture of individual tumors to guide personalized treatment approaches, with significant contributions to understanding tumor ecosystems and evolutionary patterns in brain cancers. Dr. Erson Omay's scientific contributions span neuro-oncology, computational biology, and precision medicine, with a strong emphasis on translating genomic findings into clinical applications. Her publications demonstrate consistent innovation in applying computational methods to complex neurosurgical problems, with particular focus on tumor heterogeneity, molecular classification, and racial disparities in tumor genomics. Her notable scientific awards include: 10x Genomics 2021 Pilot Award (2022) Mission Bio Tapestri Grant (2022) Case Western Reserve University, Research ShowCASE-Best Poster Award (2007) Dr. Erson Omay actively mentors students and researchers at various levels, including undergraduate students, graduate students, postdocs, and postgraduate associates. She collaborates extensively within Yale's neurosurgery department and across disciplines to advance computational approaches to brain tumor research. Her work is supported by various grants that enable the development of novel bioinformatics platforms for tumor genomic characterization. She leads the Erson Lab, which focuses on three major research areas: Tumor Ecosystem (studying interactions among tumor and immune cells), Tumor Evolution and Heterogeneity (understanding temporal and spatial tumor evolution), and Precision Medicine (applying genomic techniques to personalize brain tumor treatment). The lab employs diverse omics technologies to explore brain tumor biology and develop computational methods for precision medicine applications.

Nelly Panteمشاهده پروفایل

استاد

• Cell Biology
• Developmental Biology
• Virology
• +۵ مورد دیگر

Nelly Pante is a Professor in the Department of Zoology at the University of British Columbia, Faculty of Science. Her research focuses on nucleocytoplasmic transport, particularly the nuclear import of viral genomes and the molecular characterization of nuclear pore complexes (NPCs). Education: Ph.D. from Brandeis University; M.Sc. from The Venezuelan Institute for Scientific Research (IVIC); B.Sc. (Hons.) from Simon Bolivar University Research highlights include: Investigating bidirectional macromolecular transport through NPCs using cellular and molecular techniques, fluorescence, and electron microscopy Studying viral nuclear import of Influenza A, Hepatitis B, baculoviruses, and parvoviruses to develop antiviral strategies Developing the Xenopus oocyte model system for high-resolution nuclear transport studies Structural analysis of nucleoporins like Nup153 and Nup358/RanBP2 in NPC architecture Her lab employs advanced imaging methods and has contributed to understanding how viruses exploit nuclear transport mechanisms and how NPCs maintain cellular function in health and disease. Contact: pante@zoology.ubc.ca

• Signal Regulated Transcription
• Chromatin and Gene Regulation
• Nuclear Receptors
• +۷ مورد دیگر

W. Lee Kraus is a Professor and Director at the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center, where he also holds leadership roles including Vice Chair for Basic Sciences in the Department of Obstetrics and Gynecology, Assistant Director for Basic Research at the Simmons Comprehensive Cancer Center, and Assistant Dean for Research Development. He is also a member of the Board of Directors of the Endocrine Society (2023–2026). Ph.D., University of Illinois at Urbana-Champaign (1994) Postdoctoral Research, University of California, San Diego B.S., Cornell University (1989) Dr. Kraus's research centers on signal-regulated transcription, chromatin and gene regulation, nuclear receptors, PARPs, and NAD+ metabolism and signaling. His work has elucidated the roles of ADP-ribosylation in transcriptional control, enhancer function, and cancer biology. He has published over 150 peer-reviewed articles in top journals such as Science , Cell , and Molecular Cell . His recent publications reveal a strong focus on PARP enzymes, enhancer RNAs, NAD+ compartmentalization, and the interplay between metabolism and gene regulation. Themes across his work include the functional roles of ADP-ribosylation in transcription, splicing, translation, and cancer, with implications for therapeutic development. Scientific honors include: Endocrine Society’s Richard E. Weitzman Memorial Award (2007) Endocrine Society’s Ernst Oppenheimer Award (2014) Cornell University Teaching Excellence Award (2004) Cornell University Mentoring Excellence Award (2008) Dr. Kraus has been a successful mentor, training 22 doctoral students, 26 postdocs, and 16 clinical fellows, most of whom have secured faculty or research positions in academia or industry. His research has been supported by grants from the NIH, American Cancer Society, Burroughs Wellcome Fund, CPRIT, and NSF. He is also active in biotech, having co-founded Ribon Therapeutics and ARase Therapeutics, and serves on scientific advisory boards for startup companies. He leads the Kraus Lab at UT Southwestern, which continues to pioneer research in transcriptional regulation and metabolic signaling.

Gerta Hoxhajمشاهده پروفایل

استادیار

• Cancer Metabolism
• Cell Signaling
• Metabolomics
• +۵ مورد دیگر

Gerta Hoxhaj is an Assistant Professor at the Children's Medical Center Research Institute (CRI) at UT Southwestern Medical Center, with secondary appointments in the Departments of Biochemistry and Pediatrics. She leads an active research laboratory focused on understanding the molecular mechanisms of cancer metabolism. Dr. Hoxhaj received her academic training through the following institutions: Bachelor's degree in Molecular Biology, Genetics, and Chemistry from Bogazici University, Istanbul, Turkey Ph.D. in Biochemistry and Cell Signaling from the MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, Scotland, UK Dr. Hoxhaj's research program centers on understanding how cancer cells rewire their metabolism to support growth and survival. Her laboratory investigates three fundamental questions: how cells integrate oncogenic signals to regulate metabolic activities; how metabolism is linked to tissue function; and how cells sense metabolite abundance to maintain homeostasis. Using approaches that combine classical biochemistry, metabolomics, cell biology, and mouse models, her team has made significant contributions to understanding the role of cellular reducing power (NADPH) in cancer metabolism, particularly through the regulation of NAD kinase (NADK). Her work has revealed novel connections between PI3K-Akt-mTORC1 signaling and metabolic pathways including nucleotide synthesis and redox balance. Analysis of Dr. Hoxhaj's recent publications shows a strong focus on mitochondrial metabolism, particularly the role of NADPH in powering essential processes like fatty acid synthesis and protein lipoylation. Her research bridges structural biology (with cryo-EM studies of NADK), cellular metabolism, and cancer biology, revealing how metabolic reprogramming supports tumor growth. A consistent theme across her work is the identification of how oncogenic signaling pathways directly regulate specific metabolic enzymes and processes. Dr. Hoxhaj has received numerous prestigious awards and recognitions for her research: Cancer Prevention and Research Institute of Texas (CPRIT) Scholar in Cancer Research V Foundation Scholar American Cancer Society Scholar Pew-Stewart Scholar for Biomedical Science 2025 TAMEST Mary Beth Maddox Award and Lectureship 2024 Vilcek Prize for Creative Promise in Biomedical Science Dr. Hoxhaj mentors a dynamic research team including postdoctoral fellows, Ph.D. students, and research associates. Her laboratory has secured significant funding from multiple sources including the National Institutes of Health, Welch Foundation, CPRIT, and USDA National Institute of Food and Agriculture. Her research on cancer metabolism has important implications for developing new therapeutic strategies targeting metabolic vulnerabilities in cancer cells. The Hoxhaj Laboratory is part of the Genetic and Metabolic Disease Program at CRI, collaborating closely with other researchers at UT Southwestern including those in the Harold C. Simmons Comprehensive Cancer Center. Her team's recent work on mitochondrial NADPH has opened new avenues for understanding how metabolic pathways are rewired in cancer, with potential applications for multiple cancer types.

• Immunology
• Macrophage Biology
• Tumor-associated Macrophages
• +۴ مورد دیگر

Antonio SICA is a Full Professor in the Department of Pharmaceutical Sciences at the University of Eastern Piedmont 'Amedeo Avogadro'. With an extensive research career spanning over three decades, he has published 189 research outputs including articles, reviews, and conference contributions. His ORCID profile (0000-0002-8342-7442) documents his significant contributions to immunology and cancer research. Professor SICA's research primarily focuses on myeloid cells in cancer , particularly tumor-associated macrophages and myeloid-derived suppressor cells . His work explores how these cells contribute to tumor progression, immunosuppression, and response to therapy. Key research areas include immunometabolism, epigenetic regulation of myeloid cells, and the intersection of inflammation with cancer development. Analysis of his recent publications (2021-2024) reveals a strong emphasis on myeloid cell heterogeneity in cancer, immunometabolic pathways , and the role of myeloid cells in age-related diseases . His 2023-2024 work has particularly examined connections between cancer immunology and infectious diseases like COVID-19, demonstrating how immunometabolic interference affects disease outcomes. Advancing the knowledge of human neutrophils displaying polymorphonucler myeloid-derived suppressor cell (PMN-MDSC) functions (2023-2025) BioTher19: Biological bases of immune response in fragile COVID-19 patients Deciphering the molecular and functional heterogeneity of myeloid cells in cancer (2019-2023) Deciphering the epigenetic basis of Myeloid-derived immunosuppression in cancer and therapy (2018-2023) Professor SICA has supervised 5 students throughout his career and maintains active research collaborations across multiple institutions. His work contributes significantly to UN Sustainable Development Goals related to good health and well-being, particularly through advancing cancer immunology and immunotherapy approaches.

Zuri Sullivanمشاهده پروفایل

پژوهشگر ارشد

• Immunology
• Neuroscience
• Neuroimmunology
• +۵ مورد دیگر

Zuri Sullivan is a postdoctoral researcher at Harvard University, affiliated with the Catherine Dulac Lab. Her work focuses on the intersection of immunology and neuroscience, particularly how inflammatory signals influence social behavior in mice through hypothalamic circuits. Education: PhD in Immunobiology from Yale University AB in Molecular and Cellular Biology (MCB) from Harvard College Research interests span neuroimmunology, inflammation, and genetic screening. Key projects include studying mast cell-leukotriene signaling in anaphylaxis, hypothalamic circuitry in social homeostasis, and the role of γδ T cells in nutrient sensing. Her work often integrates immunobiology with behavioral neuroscience. Recent publications highlight her contributions to understanding immune-gut-brain axis interactions, genetic tools for tissue mapping, and disease mechanisms in obesity-related cancer and tuberculosis. She also develops innovative multimodal screening platforms for in vivo gene function analysis. Scientific Awards: HHMI Hanna H. Gray Postdoctoral Fellowship Zuri actively promotes science communication, diversity in STEM, and education outreach. She previously studied intestinal immune adaptation to diet during her PhD at Yale under Ruslan Medzhitov. Collaborations with William Bishai and Ruslan Medzhitov feature prominently in her research portfolio.

Richard Brightمشاهده پروفایل

پژوهشگر ارشد

• Biomaterials
• Microbiology
• Nanoengineering
• +۹ مورد دیگر

Richard Bright is a Research Fellow at the Biomedical Nanoengineering Laboratory within the College of Medicine and Public Health at Flinders University. His research focuses on the complex interplay between bacteria and mammalian cells on biomaterial substrates, with expertise spanning microbiology, cell biology, and molecular biology. Education: PhD, Biomedical Science from Flinders University (awarded January 20, 2024) Master of Science, Immunology from Charles Sturt University (awarded January 20, 2013) Bachelor of Science (Honors) from University of Adelaide (awarded January 12, 2008) Dr. Bright's research spans multiple interdisciplinary areas including biomaterials, antimicrobials, nanoengineering, tissue engineering, molecular and cell biology, stem cell and bone biology, and immunology. His work particularly focuses on understanding how surface properties of biomaterials influence biological responses, with applications in infection prevention, wound healing, and implant integration. His fingerprint research areas include surface science, antiinfective agents, biomaterials, infection mechanisms, silver nanoparticles, Staphylococcus aureus interactions, nanocomposites, and wound infection management. Dr. Bright has secured significant research funding, including an ARC Discovery Project (2025), Flinders Foundation Seed Grant (2024), and multiple grants from ADRF and industry partners like Colgate Palmolive. His research outputs show consistent productivity with 73 publications to date, demonstrating increasing research activity from 2021-2025. As a supervisor, Dr. Bright emphasizes open communication, collaboration, and critical thinking while providing tailored mentorship. He aims to balance hands-on guidance with encouraging independence, maintaining high ethical standards, and promoting work-life balance. He is committed to supporting students in both academic and industry career paths while fostering an inclusive research environment. His current research involves leading projects, grant writing, manuscript preparation, and supervision of students and laboratory staff. Dr. Bright is a key member of the Biomedical Nanoengineering Laboratory and the Flinders Health and Medical Research Institute. His work contributes to UN Sustainable Development Goals, particularly in health and well-being. His research has practical applications in developing next-generation antimicrobial biomaterials, improving implant integration, and advancing wound healing technologies through innovative nanoengineering approaches.

Yashi Ahmedمشاهده پروفایل

استاد

• Wnt signaling
• Molecular Biology
• Systems Biology
• +۵ مورد دیگر

Yashi Ahmed is a Professor of Molecular and Systems Biology at the Geisel School of Medicine at Dartmouth College, located at the Vermont-New Hampshire border. Dr. Ahmed leads the Ahmed Lab, which focuses on Wnt signal transduction pathways in animal development and disease. The research interests of Dr. Ahmed center on the Wnt signaling pathway, which is critical for animal development and stem cell maintenance in adult organs. The lab investigates how the Wnt receptor complex is assembled and activated, how negative regulators of the pathway are inhibited when Wnt is present, and what nuclear proteins control Wnt-dependent target gene activation. Their work has significant implications for understanding developmental disorders and cancers, including nearly all colorectal cancers. Analysis of Dr. Ahmed's publication record shows a consistent focus on Wnt signaling mechanisms across multiple model systems, particularly Drosophila . The research spans from fundamental molecular mechanisms like ADP-ribosylation of Axin (2016) to more recent work on deubiquitylases (USP46, USP47) and E3 ligases (TRIP12, Cereblon) that regulate Wnt signaling components. This body of work demonstrates an evolutionarily conserved approach to understanding Wnt pathway regulation across species including Drosophila , zebrafish, and mammalian systems. Wnt signaling pathway regulation Mechanisms of Wnt receptor activation Post-translational modifications in Wnt signaling Evolutionary conservation of Wnt pathway components Therapeutic targeting of Wnt-driven diseases Dr. Ahmed actively welcomes graduate student rotations and postdoctoral applications to continue advancing research on Wnt signaling mechanisms with therapeutic potential.

Paul Kingsleyمشاهده پروفایل

عضو هیئت علمی

• Embryonic Hematopoiesis
• Erythroid Differentiation
• Ontogeny of Hematopoietic Progenitors
• +۳ مورد دیگر

Paul Kingsley, Ph.D. is a Research Assistant Professor (Part-Time) in the Department of Pediatrics, Hematology and Oncology at the University of Rochester School of Medicine and Dentistry. His academic credentials include a Ph.D. and M.S. in Developmental Biology from the University of Rochester (1992, 1987) and a B.A. in Biology from Reed College (1982), followed by a Cancer Center Fellowship in Hematopoiesis at the University of Rochester School of Medicine and Dentistry (1992-1994). Dr. Kingsley's research focuses on: Embryonic Hematopoiesis Erythroid Differentiation Ontogeny of Hematopoietic Progenitors Erythroid Precursor Self Renewal His laboratory employs diverse approaches including subtractive hybridization, degenerate PCR, genechip technology (Affymetrix), and in situ hybridization to investigate blood formation in mammalian embryos. His work examines how hematopoiesis initiates in the yolk sac, migrates to the fetal liver, and finally homes to the bone marrow at the end of gestation. Dr. Kingsley's publication record demonstrates consistent focus on molecular mechanisms of blood cell development, with recent work emphasizing erythroid maturation, hematopoietic stem cell regulation, and chromatin dynamics during erythropoiesis. His research spans from fundamental developmental biology to potential clinical applications in blood disorders and radiation protection. Key research contributions include: Mechanisms of erythroblast enucleation and maturation Regulation of hematopoietic stem cell specification and migration Chromatin remodeling during late-stage erythropoiesis Mitochondrial iron metabolism in heme synthesis Developmental origins of immune cell lineages Effects of radiation on hematopoietic recovery Dr. Kingsley has maintained a productive research career with extensive collaboration, particularly with Dr. James Palis, resulting in numerous high-impact publications in journals such as Nature, Science, Blood, and The EMBO Journal.

Petter Brodinمشاهده پروفایل

استاد

• Systems Immunology
• Pediatric Immunology
• Immune System Regulation
• +۷ مورد دیگر

Petter Brodin is a dual-appointed academic with a Professor ship at Karolinska Institutet 's Department of Women's and Children's Health and a Senior Lecturer position at Imperial College London 's MRC London Institute of Medical Sciences. His work bridges clinical pediatrics and cutting-edge systems immunology , focusing on human immune system profiling through blood analysis. Education : MD/PhD from Karolinska Institutet, postdoc at Stanford University Research spans three major domains: Sex hormone immunomodulation - Revealing testosterone's role in suppressing autoimmune pathways while enhancing infection vulnerability through Nature studies of gender-affirming treatment Post-COVID pathophysiology - Developing antiviral treatment strategies for chronic SARS-CoV-2 reservoirs with Pfizer, focusing on severely affected patients Developmental immunology - Mapping immune-microbiome interactions in newborns and cancer immunotherapy applications in pediatric solid tumors Major awards include: 2023 Oscar Medin Prize 2024 Wallenberg Scholar 2022 VR and SSMF Consolidator Awards 2019 EMBO Young Investigator 2015 ERC Starting Grant Supervised 5 PhD/MSc students while leading a multidisciplinary team at BrodiN lab (brodinlab.com). Current clinical trials include: 15-day antiviral regimen for tissue reservoirs Immunomodulatory approaches for autoimmune profiles Active in science communication through BlueSky platform and Paris Kids Cancer Symposium leadership, emphasizing human-centric research over animal models.

David Christopher Pooleمشاهده پروفایل

استاد

• Oxygen Transport
• Exercise Physiology
• Pulmonary Gas Exchange
• +۶ مورد دیگر

Dr. David C. Poole is a University Distinguished Professor of Kinesiology and Physiology at Kansas State University, holding the Elizabeth Chapin Burke Chair in Health and Human Sciences and the Coffman Chair for University Distinguished Teaching Scholars. He serves as Director of the Clarenburg Cardiorespiratory Lab within the College of Veterinary Medicine. His work bridges the fields of kinesiology, physiology, and veterinary medicine, focusing on understanding the fundamental mechanisms of oxygen transport and utilization in health and disease. Dr. Poole earned his B.Sc. from Liverpool Polytechnic and his Ph.D. from UCLA in 1986, followed by a Scientiae Doctor from Liverpool John Moores University in 2000. His academic journey has established him as an internationally recognized researcher in exercise and respiratory physiology. Dr. Poole's research focuses on the critical relationship between oxygen transport and metabolic demands in tissues, particularly during exercise. His laboratory investigates how skeletal muscles can require up to 100-fold more oxygen during exercise compared to rest, and how conditions like heart failure, diabetes, and cancer impair this vital process. Using innovative approaches such as nitrate supplementation and dietary interventions, his work aims to enhance therapeutic strategies for improving exercise tolerance and quality of life in patients with chronic conditions. His research has significantly advanced understanding of capillary function, oxygen uptake kinetics, and Critical Power in exercise physiology. Dr. Poole's extensive publication record includes over 350 peer-reviewed papers in leading journals such as Circulation Research , Journal of Clinical Investigation , and Journal of Applied Physiology . His recent work (2023-2025) demonstrates continued leadership in understanding oxygen transport mechanisms across multiple physiological systems, with particular emphasis on skeletal muscle microcirculation, respiratory muscle function, and the impact of aging and disease on exercise capacity. His research spans fundamental physiological mechanisms to translational applications in clinical settings. Scientiae Doctor from Liverpool John Moores University (2000) Adolph Distinguished Lecturer from the American Physiological Society (2018) Joseph B. Wolffe Memorial Lecture from the American College of Sports Medicine (2021) Higuchi-Dolph Simons Statewide Award for Biomedical Research Excellence (2024) ACSM Citation Award (2019) Fellow of the American College of Sports Medicine Fellow of the American Physiological Society As Principal Investigator, Dr. Poole has secured over $6 million in research funding, with an additional $31 million as Co-Investigator, primarily from the National Institutes of Health and the K-State Johnson Cancer Research Center. His laboratory maintains a vibrant scientific atmosphere with productive collaborations among faculty and students. Key collaborators include Dr. Thomas J. Barstow, Dr. Timothy I. Musch, Dr. Howard H. Erickson, Dr. M. Roger Fedde, Dr. Casey A. Kindig, and Dr. Brad J. Behnke. Dr. Poole's work has achieved an impressive h-index of 84 with over 26,000 citations, reflecting his significant impact on the field. Dr. Poole directs the Clarenburg Cardiorespiratory Lab at Kansas State University, which provides a dynamic research environment focused on understanding oxygen transport limitations from lungs to mitochondria. The lab employs a range of novel and established strategies to investigate tissue oxygenation and metabolic control, with applications to both healthy function and disease states including emphysema, diabetes, chronic heart failure, and cancer.

• Machine Learning
• Deep Learning
• Bioinformatics
• +۷ مورد دیگر

Guanghua Xiao is a Professor at the O'Donnell School of Public Health with secondary appointments in the Departments of Bioinformatics and Biomedical Engineering at UT Southwestern Medical Center. His work focuses on developing computational models and algorithms for big data analysis in biomedical contexts, particularly for predicting patient outcomes and treatment responses.