معرفی
Yashi Ahmed is a Professor of Molecular and Systems Biology at the Geisel School of Medicine at Dartmouth College, located at the Vermont-New Hampshire border. Dr. Ahmed leads the Ahmed Lab, which focuses on Wnt signal transduction pathways in animal development and disease.
The research interests of Dr. Ahmed center on the Wnt signaling pathway, which is critical for animal development and stem cell maintenance in adult organs. The lab investigates how the Wnt receptor complex is assembled and activated, how negative regulators of the pathway are inhibited when Wnt is present, and what nuclear proteins control Wnt-dependent target gene activation. Their work has significant implications for understanding developmental disorders and cancers, including nearly all colorectal cancers.
Analysis of Dr. Ahmed's publication record shows a consistent focus on Wnt signaling mechanisms across multiple model systems, particularly Drosophila. The research spans from fundamental molecular mechanisms like ADP-ribosylation of Axin (2016) to more recent work on deubiquitylases (USP46, USP47) and E3 ligases (TRIP12, Cereblon) that regulate Wnt signaling components. This body of work demonstrates an evolutionarily conserved approach to understanding Wnt pathway regulation across species including Drosophila, zebrafish, and mammalian systems.
- Wnt signaling pathway regulation
- Mechanisms of Wnt receptor activation
- Post-translational modifications in Wnt signaling
- Evolutionary conservation of Wnt pathway components
- Therapeutic targeting of Wnt-driven diseases
Dr. Ahmed actively welcomes graduate student rotations and postdoctoral applications to continue advancing research on Wnt signaling mechanisms with therapeutic potential.
