Professor Mirko Trajkovski leads the Laboratory of Metabolic Diseases at the Faculty of Medicine, University of Geneva. He completed his PhD at the International Max Planck School in Dresden (2005), followed by postdoctoral research at ETH Zurich, before establishing his lab at University College London (2012) and moving to Geneva (2013). His work focuses on adipose tissue plasticity , gut microbiota , and their roles in obesity , diabetes , and insulin resistance . Swiss National Science Foundation Professor (2014) ERC Starting Grant (2014) & Consolidator Grant (2019) Dr Walter Seipp Prize & Carl Gustav Carus Prize (2005) His lab investigates fat browning mechanisms , microbiota-host communication , and multi-tissue metabolic regulation using in vivo , in vitro , and human cohort approaches. Recent publications emphasize microbiome-based therapies , temperature effects on metabolism , and gut-bone-adipose crosstalk . Current advisees include PhD student Silas Kieser, with past members like Jing Xue, Salvatore Fabbiano, and Claire Chevalier contributing to immuno-metabolism and microbial engineering projects.
Dr. Xin Zhou is an Oxford-Bristol Myers Squibb Fellow at the Department of Computer Science, University of Oxford. Her research integrates computational modeling, clinical data, and experimental findings to investigate cardiac disease mechanisms and develop human-based simulations for drug evaluation. BSc and MSc in Life Sciences, Beijing Normal University DPhil in Computational Biology, University of Oxford Her work focuses on multi-scale cardiac modeling , particularly in ischemic heart disease and heart failure, exploring ionic currents, tissue conduction, and organ-level dynamics. She develops electromechanical simulations to study cardiac alternans and arrhythmic risks, translating these into clinical applications for patient stratification and pharmaceutical testing. Recent publications emphasize in silico clinical trials , sex-specific cardiometabolic analysis, and Purkinje network modeling. Collaborative efforts with clinicians and pharmaceutical partners highlight her translational approach to regulatory science. Model of the Year 2024, BioModels EPSRC Impact Acceleration Account Microsoft Research Project Award Recognition Award, University of Oxford She supervises PhD and MSc students in computational cardiology, while serving on the editorial board of Frontiers in Physiology . Her current projects involve digital twinning and predictive cardiac safety models to reduce animal testing reliance.
Ruben Portugues is a Professor of Brain Circuit Function and Dysfunction at the Institute of Neuroscience, Technical University of Munich (TUM). He is a full member of the Graduate School of Systemic Neurosciences (GSN), an associate and advisory board member of the Munich Center for Neurosciences (MCN), and leads a research group focused on understanding the neural basis of behavior. His lab uses larval zebrafish as a model organism to investigate sensorimotor control, decision-making, and motor learning through whole-brain imaging and circuit analysis. His research interests lie at the intersection of systems neuroscience and behavior. He investigates how brain circuits process sensory information, integrate it with motor output, and enable adaptive and flexible behavior. Key areas include the function of the cerebellum, heading direction networks, sensorimotor transformations, and the neural mechanisms of decision-making. His lab employs cutting-edge techniques including custom-built microscopes, behavioral assays, and computational analysis. The recent publications and preprints from his lab demonstrate a strong trend in decoding distributed neural circuits underlying navigation and decision-making in zebrafish. There is a clear focus on identifying specific brain regions (e.g., interpeduncular nucleus, cerebellum) and cell types involved in processing visual, motor, and spatial information. The work increasingly emphasizes whole-brain functional imaging and the emergence of cognitive-like representations such as allocentric heading direction. FENS-Kavli Network of Excellence (FKNE) PhD Thesis Prize (awarded to student Luigi Petrucco) Ruben Portugues actively mentors PhD students, including current advisees Luigi Petrucco, Ot Prat, and Shuhong Huang, and has successfully graduated Dr. Elena Dragomir and Dr. Vilim Štih. His lab engages in extensive collaborations, hosts visiting researchers, participates in teaching (e.g., CSHL Imaging Course, Cajal Course), and secures resources for advanced research. The lab is known for building its own microscopes and software, fostering technical innovation. The Portugues Lab operates as a dynamic, interdisciplinary team that combines experimental neuroscience with computational and engineering approaches. They regularly hold retreats, participate in scientific events, and contribute to community initiatives like the Munich Brain Day. The lab is preparing to relocate to the Department of Neurobiology and Behavior at Cornell University, marking a new phase in its research trajectory.
Lonny R. Levin is a Professor of Pharmacology at Weill Cornell Medical College , where he has worked since 2009. Collaborating extensively with Dr. Jochen Buck, he pioneered research on bicarbonate-regulated soluble adenylyl cyclase (sAC) , a critical enzyme in cAMP signaling. Education : B.S. from Cornell University (1983), Ph.D. from State University of New York at Stony Brook (1989) His research focuses on: cAMP signaling microdomains in mammalian cells Mitochondrial metabolism and pH sensing Sperm capacitation and energy regulation Nonhormonal contraceptive development via sAC inhibition Recent publications (2025-2023) highlight: Structural insights into sAC activation Metabolic adaptations during sperm capacitation Emerging role in corneal endothelium signaling Drug discovery for on-demand male contraception Grants from NIH (NIAID, NICHD) support his work on: Intravaginal rings for dual HIV/herpes prevention and contraception Metabolic communication in reproductive systems Signalosome regulation in mitochondria He maintains collaborations with institutions like EMD Millipore Corporation and co-founded Sacyl Pharmaceuticals, Inc. , holding proprietary interests in sAC-related intellectual property.
Molly Maleckar is a Research Professor at the Computational Physiology Department of Simula Research Laboratory , Oslo, Norway. Her work bridges computational modeling, cardiac electrophysiology, and biomedical applications, with a focus on arrhythmia mechanisms, fibrosis modeling, and machine learning integration in cardiac risk prediction. Research Interests include: Computational Cardiology Ion Channel Dynamics Machine Learning in Medicine Excitable Tissue Modeling Cardiac Fibrosis Analysis Biomedical Simulation Scientific Contributions span 15+ publications (2018-2024) addressing atrial fibrillation, calcium handling, and AI-driven ECG analysis. Key collaborative projects involve patient-specific ventricular modeling and educational initiatives like the Simula Summer School in Computational Physiology .
Professor Richard Wade-Martins is a leading academic in University of Oxford 's Department of Physiology, Anatomy and Genetics . He directs the Molecular Neurodegeneration Research Laboratory and the Oxford Parkinson’s Disease Centre (OPDC). With degrees from Cambridge (MA) and Oxford (DPhil), he has held prestigious fellowships including Wellcome Trust Research Career Development Fellowship and NIH reviewer roles. His research targets molecular mechanisms in Parkinson’s and Alzheimer’s diseases through iPSC models , transgenic mice , and lysosomal function studies . He pioneered work on SNCA , MAPT , and LRRK2 gene pathways. Current projects focus on gene therapy and mitochondrial dysfunction in neurodegeneration. Key publications (2019–2025) reveal trends in single-cell transcriptomics , calcium channel inhibition , and TFEB/TFE3 lysosome modulation . His awards include Wellcome Trust Fellowships and advisory roles for Parkinson's UK , Alzheimer's Research UK , and EU consortia like StemBANCC and EFACTS . He leads the UK Dementia Platform iPSC Initiative and serves on international boards in Luxembourg and Canada.
Prof. Stephan J. Sigrist is a Full Professor of Genetics at the Institute of Biology, Free University of Berlin. His lab focuses on synaptic active zone architecture, neuroplasticity, and aging-related neurodegeneration. He leads the Collaborative Research Center 958 on Membrane Scaffolding and co-directs NeuroCure, a DFG Cluster of Excellence at Charité. Education: PhD in Molecular Genetics (1997) and Habilitation (2005) from the University of Göttingen. Positions: Einstein Professor (2014–present), Spokesperson CRC 958 (2012–present), and Co-Director NeuroCure (2009–present). Research explores presynaptic mechanisms using Drosophila and mouse models, combined with STED microscopy. Key contributions include discoveries of Bruchpilot's role in active zones and spermidine's protective effects against age-related synapse decline. Grants: Over €6 million in funding, including DFG CRCs, Einstein Foundation, and ERC Advanced Grant (2025). Awards: Einstein Professorship, Best Habilitation Award, EMBO/HFSP Fellowships. Collaborations span structural biology (e.g., Stefan Hell), neurophysiology (David DiGregorio), and aging research (Frank Madeo).
Vignesh Ram Somnath is a Professor in the Biosciences of Sports at the University of Hildesheim since 2018. Previously, he served as an Acting Professor (2016-2018) and Research Associate (2010-2016) at the Institute of Sports Science, German Sports School Cologne. His work bridges molecular biology with sports science, focusing on skeletal muscle adaptation. Current: University Professor W2, University of Hildesheim 2016-2018: Acting Professor, University of Hildesheim 2010-2016: Research Associate, German Sports School Cologne 2005-2007: Research Assistant, German Sports School Cologne Research Interests: Regulation of molecular signaling pathways in skeletal muscle Mechanoprotective mechanisms during exercise Protein degradation dynamics Optimization of training and nutrition in competitive sports Integration of molecular biology with traditional sports science Key Publications (2020-2017) demonstrate expertise in: Metabolomics of muscle hypertrophy AMPK signaling in training Mitochondrial adaptations Extracellular vesicle analysis Calcium signaling pathways
Alicia Che is an Assistant Professor of Psychiatry at Yale University School of Medicine and serves as Director of Graduate Admissions for the Interdepartmental Neuroscience Program. She joined the Yale Department of Psychiatry in 2021 after completing her postdoctoral fellowship with Dr. Natalia De Marco García at Weill Cornell Medical College and Dr. Gord Fishell at NYU. Her research is conducted through the Che Lab at Yale, where she investigates how early life experiences impact brain circuit assembly and mature function in models of psychiatric illness. Yale School of Medicine, Department of Psychiatry Interdepartmental Neuroscience Program Center for Brain & Mind Health Division of Molecular Psychiatry Wu Tsai Institute Yale Center for the Science of Cannabis and Cannabinoids Dr. Che earned her Ph.D. in Physiology and Neurobiology from the University of Connecticut in 2014, where she worked in the laboratory of Dr. Joseph LoTurco. She received her B.S. with triple majors in Biology, Physics, and Physical Chemistry from Pacific Lutheran University in Washington state in 2009. Her research focuses on understanding developmental trajectories following early life experiences to develop diagnostics and early interventions for psychiatric illnesses. Dr. Che's research examines how sensory inputs, social bonding, stress, and substance exposure impact brain development. She employs a multi-dimensional approach to assess transcriptional, circuit, neuronal activity, and behavioral changes across the entire developmental timeline. Her lab currently focuses on four specific areas: the role of oxytocin in social behavior development, circuit dysfunction in PTSD, early-life cannabinoid exposure effects, and the impact of early life stress on development and adulthood. She utilizes advanced techniques including mouse genetics, slice electrophysiology, and longitudinal in vivo 2-photon imaging on behaving animals. Her most recent publications demonstrate significant contributions to understanding neural circuit development, PTSD mechanisms, and the effects of early life experiences on brain function. Her work spans from molecular neuroscience to behavioral outcomes, with publications in top journals including Nature, Neuron, and Nature Communications. Her research has revealed important insights into how translaminar neuronal activity strengthens cortical columns, how oxytocin facilitates social touch development, and how PTSD affects brain transcriptomics. NARSAD Young Investigator Award (2020) K99/R00 Pathway to Independence Award from NINDS (2019) Dr. Che's work has significant implications for understanding and treating neurodevelopmental disorders, PTSD, and the consequences of early life experiences on mental health. She collaborates extensively with researchers across Yale and beyond, with frequent co-authorship with colleagues including Lin Lin, Alex Kwan, and Christopher Pittenger. Her research program bridges basic neuroscience with clinical applications, aiming to translate findings into potential interventions for psychiatric conditions.
Dr. Teresa Puthussery is an Associate Professor in the School of Optometry & Vision Science at the University of California, Berkeley. Her research focuses on retinal neurobiology and neurophysiology, investigating how visual signals are encoded in healthy retinas and disrupted during degeneration. She uses advanced techniques like patch-clamp electrophysiology, immunohistochemistry, and microscopy to study retinal circuits, neurotransmitter receptors, and ion channels. Dr. Puthussery teaches courses on vision science anatomy, physiology, and problem-based learning, including VISION SCIENCE 206B/C and 260C. Her research explores questions such as how retinal neurons extract motion/spatial details, how photoreceptor mutations cause degeneration, and how inner retinal circuits adapt post-photoreceptor loss. Recent work includes studies on ON-type direction-selective ganglion cells, optogenetic therapy for vision restoration, and calcium dynamics in foveal ganglion cells post-degeneration. She collaborates on projects involving primate and rodent models, contributing to understanding retinal disease mechanisms and therapeutic targets. Dr. Puthussery’s lab (retinalab.berkeley.edu) emphasizes translational research, bridging basic science and clinical applications. Her work has been published in journals like Nature and Cell Reports , with a focus on retinal degeneration, synaptic plasticity, and optogenetic interventions. She actively participates in training future vision scientists through Berkeley’s Optometry program and oversees GSI affairs as a faculty advisor.
Nicholas M. Kanaan is a Professor of Translational Neuroscience and holds the Maibach Smiley Professorship of Alzheimer's Research at Michigan State University's College of Human Medicine. He serves as Director of Advanced Microscopy and is faculty in both the MSU Neuroscience Program and the MSU BioMolecular Science Gateway. His research is centered at the Grand Rapids Research Center where he leads the Kanaan Laboratory. Dr. Kanaan received his B.S. in Neuroscience, Psychology, and Sociology from Central Michigan University in 2001, followed by a Ph.D. in Neurological Sciences from Rush University Medical Center in 2007. He completed postdoctoral training at Northwestern University from 2007-2010 under Dr. Lester Binder. His research focuses on neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD), with emphasis on tau protein pathology. The Kanaan Lab investigates mechanisms underlying degenerative diseases using a combination of in vitro and in vivo model systems. A major focus is understanding how disease-related alterations in tau cause neuronal dysfunction through disruption of axonal transport. His lab has identified a phosphatase-activating domain (PAD) in tau that inhibits anterograde fast axonal transport. Analysis of Dr. Kanaan's publication record reveals a consistent focus on tau protein biology, with recent work emphasizing iPSC models, CRISPR screening, tau proteostasis, and therapeutic interventions targeting tau phosphorylation and oligomerization. His research spans basic molecular mechanisms to translational applications, with increasing use of primate models and advanced screening technologies in recent years. Scientific Awards and Recognition: Maibach Smiley Alzheimer's Research Professor Maibach Smiley Professor of Alzheimer's Research Dr. Kanaan mentors numerous students and postdoctoral fellows in his laboratory, with research supported by multiple grants focused on understanding and treating neurodegenerative diseases. His lab employs a wide range of technical expertise including recombinant protein purification, cell culture, monoclonal antibody production, various microscopy techniques, and behavioral testing in rodent models. Outside the lab, Dr. Kanaan enjoys photography, woodworking, and fishing.
Scott L. Diamond is the Arthur E. Humphrey Professor of Chemical and Biomolecular Engineering and Bioengineering at the University of Pennsylvania's School of Engineering and Applied Sciences. He serves as Director of the Penn Center for Molecular Discovery, Director of the Penn Biotechnology Masters Program (one of the largest in the country with over 130 students), and Associate Director of the Institute for Medicine and Engineering (IME). His laboratory is located in the Roy and Diana Vagelos Laboratories at 3340 Smith Walk, 1020 Vagelos Research Laboratories, Philadelphia, PA. Diamond's research spans multiple interconnected fields in blood biology and biotechnology. His work focuses on mechanobiology, thrombolysis, coagulation, bioadhesion, gene therapy, drug/device development, proteomics, drug discovery, systems biology, and microfluidics. His laboratory has developed numerous specialized microfluidic devices for studying blood clotting under various flow conditions, including 8-channel devices for high-throughput clotting assays, side-view devices for clot structure analysis, stenosis devices for high shear clotting assays, and impingement-post devices for studying von Willebrand factor fibers. Diamond's research group has pioneered approaches to model and predict blood function using systems biology principles. His team has developed computational models that integrate reaction-transport phenomena with platelet signaling networks to predict thrombus formation under flow. These models have enabled the development of 'virtual blood' computer simulations that can predict the effectiveness of anticoagulation drugs for individual patients, contributing significantly to personalized medicine approaches in hemostasis and thrombosis. His extensive publication record demonstrates a consistent focus on understanding the fundamental mechanisms of blood clot formation and dissolution. Recent work has emphasized microfluidic approaches for point-of-care diagnostics, patient-specific modeling of platelet function, and the development of novel therapeutic strategies for thrombotic disorders. His research bridges engineering principles with clinical hematology to address significant challenges in cardiovascular medicine. NSF National Young Investigator Award NIH FIRST Award American Heart Association Established Investigator Award AIChE Allan P. Colburn Award George Heilmeier Excellence in Research Award Elected Fellow of the Biomedical Engineering Society (BMES) Diamond has secured significant research funding, including a $2.8 million NIH grant for 'Blood Systems Biology' and a $9.5 million NIH grant for the Penn Center for Molecular Discovery. His laboratory has developed numerous microfluidic devices for blood analysis and has collaborated extensively with clinicians and industry partners. Diamond has served on advisory committees for NSF, NIH, AHA, and NASA, and has consulted extensively for industry and government. With over 180 publications and patents, his work has significantly advanced the understanding of blood clotting mechanisms and the development of diagnostic and therapeutic approaches for thrombotic disorders.
Caryl E. Sortwell is a Professor of Translational Neuroscience and Edwin A. Brophy Endowed Chair in Central Nervous System Disorders at Michigan State University's College of Human Medicine. She leads the Sortwell Lab within the Neuroscience Program and Grand Rapids Research Center, focusing on Parkinson's disease (PD) therapeutics. Education : B.S. in Psychology/Pre-medicine (University of Illinois, 1987), Ph.D. in Anatomy and Cell Biology/Neurobiology (University of Illinois at Chicago, 1994) Positions : Assistant/Associate Professor at Rush University Medical Center (1997-2005), Associate Professor at University of Cincinnati (2005-2009), Professor at MSU College of Human Medicine (2009-present) Her research investigates alpha-synuclein pathology in PD using preformed fibril models to study neurodegeneration, neuroinflammation, and therapeutic interventions. She explores neurotrophic factors like BDNF, gene therapies targeting CaV1.3 channels, and deep brain stimulation mechanisms. Her work emphasizes precision medicine approaches to optimize treatment outcomes. Scientific contributions include methodological advancements in neurochemical sensing with diamond electrodes and viral vector delivery systems. Key collaborations include research with Dr. Joe Patterson on alpha-synuclein genetic consequences. Technical Expertise : Immunohistochemistry, stereotactic surgery, in vivo neurotoxicant models, protein analysis (Western blot/ELISA), droplet digital PCR, and neuroinflammatory profiling
Scott Garman is Professor of Biochemistry at UMass Amherst, focusing on structural biology of glycoproteins in human diseases. PhD from Harvard University. Research areas: Lysosomal enzyme mechanisms in storage diseases (Fabry, Schindler); Malaria surface protein structures; Antibody-receptor interactions. Utilizes X-ray crystallography to study enzyme mutations causing disease. Key findings: Determined structures of α-galactosidase (Fabry disease) and α-NAGAL (Schindler disease), revealing molecular bases for enzyme dysfunction. Developed models for enzyme trafficking and substrate processing. Laboratory: Investigates protein folding diseases and develops therapeutic strategies. Collaborates on malaria vaccine development and antibody engineering.
Dr. Alexandre Marques is an Assistant Professor at the University of Southern Mississippi. His expertise spans Microbiology, Immunology, and Parasitology, with a focus on vaccine development against parasitic infections like Leishmaniasis, Chagas disease, and Malaria. He holds a PhD from the Universidade de São Paulo (2007) and teaches courses such as Gen Microbiology and Microorg Hth Di at the university. His research integrates immunological, clinical, and molecular approaches to understand parasitic disease mechanisms and therapeutic interventions. Notable areas include α-Gal immunization strategies, transcriptomic analysis of breast cancer, and vaccine design against Leishmania. He has also explored applications in aquaculture nutrition and cosmetic safety assessments. Dr. Marques’ work spans interdisciplinary collaborations, including veterinary medicine, nanotechnology-based drug delivery, and antimicrobial stewardship in pediatrics. His contributions to animal models for Chagas disease and canine visceral leishmaniasis highlight translational research impact. Key themes in his publications include immune response modulation, pathogen-host interactions, and biomarker discovery in chronic infections. He has published over 50 articles across microbiology, immunology, and biomedical engineering since 2007.
