معرفی
Alicia Che is an Assistant Professor of Psychiatry at Yale University School of Medicine and serves as Director of Graduate Admissions for the Interdepartmental Neuroscience Program. She joined the Yale Department of Psychiatry in 2021 after completing her postdoctoral fellowship with Dr. Natalia De Marco García at Weill Cornell Medical College and Dr. Gord Fishell at NYU. Her research is conducted through the Che Lab at Yale, where she investigates how early life experiences impact brain circuit assembly and mature function in models of psychiatric illness.
- Yale School of Medicine, Department of Psychiatry
- Interdepartmental Neuroscience Program
- Center for Brain & Mind Health
- Division of Molecular Psychiatry
- Wu Tsai Institute
- Yale Center for the Science of Cannabis and Cannabinoids
Dr. Che earned her Ph.D. in Physiology and Neurobiology from the University of Connecticut in 2014, where she worked in the laboratory of Dr. Joseph LoTurco. She received her B.S. with triple majors in Biology, Physics, and Physical Chemistry from Pacific Lutheran University in Washington state in 2009. Her research focuses on understanding developmental trajectories following early life experiences to develop diagnostics and early interventions for psychiatric illnesses.
Dr. Che's research examines how sensory inputs, social bonding, stress, and substance exposure impact brain development. She employs a multi-dimensional approach to assess transcriptional, circuit, neuronal activity, and behavioral changes across the entire developmental timeline. Her lab currently focuses on four specific areas: the role of oxytocin in social behavior development, circuit dysfunction in PTSD, early-life cannabinoid exposure effects, and the impact of early life stress on development and adulthood. She utilizes advanced techniques including mouse genetics, slice electrophysiology, and longitudinal in vivo 2-photon imaging on behaving animals.
Her most recent publications demonstrate significant contributions to understanding neural circuit development, PTSD mechanisms, and the effects of early life experiences on brain function. Her work spans from molecular neuroscience to behavioral outcomes, with publications in top journals including Nature, Neuron, and Nature Communications. Her research has revealed important insights into how translaminar neuronal activity strengthens cortical columns, how oxytocin facilitates social touch development, and how PTSD affects brain transcriptomics.
- NARSAD Young Investigator Award (2020)
- K99/R00 Pathway to Independence Award from NINDS (2019)
Dr. Che's work has significant implications for understanding and treating neurodevelopmental disorders, PTSD, and the consequences of early life experiences on mental health. She collaborates extensively with researchers across Yale and beyond, with frequent co-authorship with colleagues including Lin Lin, Alex Kwan, and Christopher Pittenger. Her research program bridges basic neuroscience with clinical applications, aiming to translate findings into potential interventions for psychiatric conditions.
