معرفی
Arie Kaffman, MD, PhD, is an Associate Professor of Psychiatry at Yale School of Medicine and Principal Investigator at the Kaffman Lab. He specializes in translational neuroscience, focusing on the impact of early life adversity (ELA) on neurodevelopment and psychiatric behaviors. His work integrates molecular, genomic, and imaging techniques (e.g., fMRI, dMRI) in rodent models to bridge findings with human clinical studies. Kaffman treats veterans with PTSD at the Newington VA and leads NIH-funded research exploring microglial function, synaptic pruning, and white matter connectivity deficits caused by ELA.
- Education: MD (2005, Yale SOM), PhD (1999, UCSF Biochemistry)
- Affiliations: Connecticut Mental Health Center, Division of Molecular Psychiatry, Interdepartmental Neuroscience Program
- Research Themes: Sex differences in ELA effects, neurodevelopmental circuits, translational imaging
Publications highlight ELA’s role in altering synaptic maturity, hippocampal connectivity, and anxiety behaviors, with emphasis on microglial mechanisms. Key findings include sex-specific deficits in perforant pathway connectivity and contextual memory in mice exposed to ELA, and impaired synaptic pruning in the hippocampus.
Notable grants include NIH funding for projects on microglial function and structural brain network changes. Collaborations with researchers like Rafiad Islam and Joel Gelernter advance understanding of ELA’s molecular and cellular underpinnings.
Kaffman’s lab is located at 300 George Street, New Haven, CT, and actively investigates therapeutic targets for ELA-related disorders, including white-matter repair strategies.