معرفی
Ruben Portugues is a Professor of Brain Circuit Function and Dysfunction at the Institute of Neuroscience, Technical University of Munich (TUM). He is a full member of the Graduate School of Systemic Neurosciences (GSN), an associate and advisory board member of the Munich Center for Neurosciences (MCN), and leads a research group focused on understanding the neural basis of behavior. His lab uses larval zebrafish as a model organism to investigate sensorimotor control, decision-making, and motor learning through whole-brain imaging and circuit analysis.
His research interests lie at the intersection of systems neuroscience and behavior. He investigates how brain circuits process sensory information, integrate it with motor output, and enable adaptive and flexible behavior. Key areas include the function of the cerebellum, heading direction networks, sensorimotor transformations, and the neural mechanisms of decision-making. His lab employs cutting-edge techniques including custom-built microscopes, behavioral assays, and computational analysis.
The recent publications and preprints from his lab demonstrate a strong trend in decoding distributed neural circuits underlying navigation and decision-making in zebrafish. There is a clear focus on identifying specific brain regions (e.g., interpeduncular nucleus, cerebellum) and cell types involved in processing visual, motor, and spatial information. The work increasingly emphasizes whole-brain functional imaging and the emergence of cognitive-like representations such as allocentric heading direction.
- FENS-Kavli Network of Excellence (FKNE) PhD Thesis Prize (awarded to student Luigi Petrucco)
Ruben Portugues actively mentors PhD students, including current advisees Luigi Petrucco, Ot Prat, and Shuhong Huang, and has successfully graduated Dr. Elena Dragomir and Dr. Vilim Štih. His lab engages in extensive collaborations, hosts visiting researchers, participates in teaching (e.g., CSHL Imaging Course, Cajal Course), and secures resources for advanced research. The lab is known for building its own microscopes and software, fostering technical innovation.
The Portugues Lab operates as a dynamic, interdisciplinary team that combines experimental neuroscience with computational and engineering approaches. They regularly hold retreats, participate in scientific events, and contribute to community initiatives like the Munich Brain Day. The lab is preparing to relocate to the Department of Neurobiology and Behavior at Cornell University, marking a new phase in its research trajectory.
