معرفی
Lonny R. Levin is a Professor of Pharmacology at Weill Cornell Medical College, where he has worked since 2009. Collaborating extensively with Dr. Jochen Buck, he pioneered research on bicarbonate-regulated soluble adenylyl cyclase (sAC), a critical enzyme in cAMP signaling.
- Education: B.S. from Cornell University (1983), Ph.D. from State University of New York at Stony Brook (1989)
His research focuses on:
- cAMP signaling microdomains in mammalian cells
- Mitochondrial metabolism and pH sensing
- Sperm capacitation and energy regulation
- Nonhormonal contraceptive development via sAC inhibition
Recent publications (2025-2023) highlight:
- Structural insights into sAC activation
- Metabolic adaptations during sperm capacitation
- Emerging role in corneal endothelium signaling
- Drug discovery for on-demand male contraception
Grants from NIH (NIAID, NICHD) support his work on:
- Intravaginal rings for dual HIV/herpes prevention and contraception
- Metabolic communication in reproductive systems
- Signalosome regulation in mitochondria
He maintains collaborations with institutions like EMD Millipore Corporation and co-founded Sacyl Pharmaceuticals, Inc., holding proprietary interests in sAC-related intellectual property.
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