جست‌وجوی استاد و پژوهشگر

Karl Peter Gieseمشاهده پروفایل

استاد

• Neurobiology of Mental Health
• Alzheimer's Disease
• Synaptic Plasticity
• +۶ مورد دیگر

Professor Karl Peter Giese holds the position of Professor of Neurobiology of Mental Health and Co-Head of the Basic & Clinical Neuroscience Department at King's College London's Institute of Psychiatry, Psychology & Neuroscience (IoPPN). His research focuses on memory mechanisms in health and disease, particularly Alzheimer's pathology, synaptic dysfunction, and aging effects. He leads projects funded by Alzheimer's Research UK and other institutions, investigating molecular and cellular bases of memory storage. His work bridges experimental models (e.g., mice) with translational insights for clinical applications. He has over 140 publications, including high-impact studies on CYFIP proteins in dementia and CaMKII in synaptic plasticity. Collaborations include researchers at King's College London and international partners. His lab explores mechanisms linking amyloid-beta, tau, and synaptic proteins to cognitive decline, with recent work applying computational methods to model aging brains. Education: PhD from ETH Zurich (1992), MSc Chemistry from Ruhr-University Bochum (1989). Current grants include Alzheimer's Research UK Network Centres and studies on MNK inhibition for Alzheimer's therapies. Projects span protein synthesis dysregulation, thalamic amyloid pathology, and intellectual disability genetics. His research has been featured in Nature Neuroscience , Brain , and Neuron . He advises on translational neuroscience initiatives and mentors early-career researchers.

• Cardiac Electrophysiology
• Biomedical Instrumentation
• Mechanoelectric Feedback
• +۷ مورد دیگر

Irene del Canto Serrano is a Researcher in the Department of Electronic Engineering at the School of Engineering, Universitat de València. Her work integrates biomedical engineering with cardiac electrophysiology, focusing on the interaction between mechanical forces and electrical activity in the heart. She is actively involved in two key research groups: GRELCA (Cardiac Electrophysiology group) and i2N (Electronic Instrumentation in Medical and Nuclear Physics), reflecting her dual expertise in physiology and instrumentation. Education: PhD in Biomedical Engineering, Universitat Politècnica de València (2015). Thesis: Estudio de las modificaciones farmacológicas de los efectos electrofisiológicos producidos por el estiramiento local miocárdico a partir de técnicas dinámicas de cartografía eléctrica, en un modelo experimental de corazón aislado de conejo , supervised by Dr. David Moratal Pérez and Dr. Francisco Javier Chorro Gascó. Her research interests center on cardiac electrophysiology , particularly mechanoelectric feedback , myocardial stretch , arrhythmia mechanisms , and pharmacological modulation using experimental models. She also explores cardiac imaging , especially cardiac MRI for strain and deformation analysis, and applies machine learning to improve detection and classification in myocardial infarction. Her recent publications highlight a strong trend toward integrating biomarkers (e.g., ferritin), iron therapy , and cardiac function recovery in heart failure, showing translational relevance. Her 15 most recent publications reflect a consistent focus on experimental cardiology using isolated heart models, pharmacological interventions (ranolazine, GS967, eleclazine), and advanced imaging techniques. She investigates how drugs affect stretch-induced arrhythmias, evaluates MRI-based strain changes post-iron therapy, and develops AI tools for cardiac image analysis. These works span basic science (e.g., CaMKII inhibition) to clinical applications (e.g., Myocardial-IRON trial analysis). Scientific Awards: No scientific awards mentioned in the provided text. Advising and Grants: While no formal students or grants are listed, her role as a postdoctoral researcher and active publication record suggest involvement in mentoring junior researchers and contributing to funded projects, particularly within the GRELCA and i2N groups. She has co-authored numerous experimental studies, indicating strong collaborative and project-based research activity. Labs and Teams: Irene is affiliated with two prominent research groups at Universitat de València: GRELCA (Cardiac Electrophysiology group) , which studies arrhythmia mechanisms and therapeutic interventions, and i2N (Electronic Instrumentation in Medical and Nuclear Physics) , which develops advanced tools for medical diagnostics. These affiliations underscore her interdisciplinary approach, combining physiology, engineering, and data science.

Harold A. Singerمشاهده پروفایل

استاد

• Vascular Biology
• Calcium Signaling
• Vascular Smooth Muscle Physiology
• +۳ مورد دیگر

Dr. Harold A. Singer is a Professor and Chair in the Department of Molecular and Cellular Physiology at Albert Einstein College of Medicine. His research focuses on calcium signaling mechanisms in vascular smooth muscle cells, particularly the role of CaMKII isoforms in regulating gene transcription and vascular remodeling. Research spans vascular biology , signal transduction , and cardiovascular pathophysiology Key interests include CREB phosphorylation , CaMKIIδ function , and vessel injury responses His recent work examines CaMKII-endothelium interactions in re-endothelialization and angiogenesis . Grants from the NIH (R01 HL049426, R01 HL092510) support his investigations into vascular remodeling and disease mechanisms .

Thomas Marescaمشاهده پروفایل

دانشیار

• Cell Biology
• Molecular Biology
• Chromosome Segregation
• +۳ مورد دیگر

Thomas Maresca is an Associate Professor in the Biology Department at the University of Massachusetts Amherst, serving as Graduate Program Director for Molecular & Cellular Biology within the Interdisciplinary Doctoral Graduate Program (IDGP). His research laboratory investigates fundamental mechanisms of cell division with institutional affiliation to the university's life sciences division. His academic training includes: Ph.D. in Cell Biology from the University of California at Berkeley (2005) B.S. in Biology from the University of North Carolina at Chapel Hill (1999) Dr. Maresca's research centers on chromosome segregation mechanics during mitosis, employing Drosophila and Xenopus model systems with advanced live-cell imaging techniques. His laboratory specializes in quantifying kinetochore-microtubule interactions , error correction mechanisms , and force generation during cell division. Key approaches include FLIM-FRET biosensors, single-molecule tracking, and micromanipulation in egg extracts to dissect how intrinsically disordered proteins, motor complexes (particularly dynein), and kinase networks (Aurora A/B, MPS1) ensure mitotic fidelity. Current work focuses on spatiotemporal regulation of phosphorylation gradients and mechanical feedback at the kinetochore-microtubule interface. Analysis of his 15 most recent publications reveals a consistent trajectory in mitotic mechanics with increasing emphasis on intrinsically disordered proteins as mechanical regulators and subcellular signaling hubs . His work bridges molecular biophysics with cellular function, demonstrating how microtubule plus-ends act as physical signaling platforms and how kinase crosstalk establishes precise spatiotemporal control during anaphase. Recent methodological innovations include commercial FLIM-FRET adaptation and quantitative force measurements at kinetochores. As Graduate Program Director, Dr. Maresca oversees curriculum development and student mentorship for the Molecular & Cellular Biology track. His laboratory (located in Morrill Science Center IV, Room 436) maintains active research programs in kinetochore mechanics and mitotic regulation, supported by continuous publication output since 2000. Collaborative networks include structural biologists and biophysicists investigating mechanochemical transduction in division processes.

Roger J. Colbranمشاهده پروفایل

استاد

• Neuroscience
• Biochemistry
• Synaptic Plasticity
• +۶ مورد دیگر

Roger J. Colbran, PhD, is a Professor and Vice Chair in the Department of Molecular Physiology and Biophysics at Vanderbilt University School of Medicine. His research focuses on calcium/calmodulin-dependent protein kinase II (CaMKII) and its roles in synaptic signaling, neuropsychiatric disorders, and neurological conditions. His lab investigates mechanisms of synaptic plasticity, particularly in the striatum and hippocampus, with implications for learning, memory, and disease. Key affiliations include the Vanderbilt Brain Institute, Vanderbilt Kennedy Center, and Vanderbilt Center for Addiction Research. His work integrates biochemistry, electrophysiology, and proteomics to study CaMKII interactions with receptors (e.g., NMDA, voltage-gated calcium channels) and signaling pathways (e.g., endocannabinoids, phosphatase regulation). Recent articles highlight CaMKII’s role in striatal sociability, nuclear signaling via Shank3 interactions, and ASD-related mutations. His lab’s multidisciplinary approach bridges basic neuroscience with translational research on disorders like addiction and neurodegeneration.

Ana Fiszbeinمشاهده پروفایل

استادیار

• Gene Regulation
• RNA Processing
• Systems Biology
• +۳ مورد دیگر

Ana Fiszbein is an Assistant Professor of Biology at Boston University, specializing in gene regulation and RNA processing. Her lab employs high-throughput genomics, bioinformatics, and molecular approaches to study co-transcriptional gene regulation in mammalian systems, with a focus on cancer genomics and therapeutic strategies. She earned her PhD from the University of Buenos Aires and leads research on how gene architecture influences transcriptional programs. Her research interests include understanding the interplay between transcription and splicing, particularly through phenomena like Exon-Mediated Activation of Transcription Starts (EMATS). The lab develops computational tools like evopython to predict gene regulatory networks and designs strategies to manipulate gene expression for therapeutic applications. Current projects explore promoter-driven RNA processing decisions, transcriptional interference between promoters, and the connection between transcript initiation and termination. The lab actively recruits undergraduate, graduate, and postdoctoral researchers. Key findings include the discovery of hybrid exons and splicing-dependent transcriptional control mechanisms.

Paul Millerمشاهده پروفایل

استاد

• Computational Neuroscience
• Neuroscience
• Dynamical Systems
• +۵ مورد دیگر

Paul Miller is a Professor of Biology at Brandeis University and a member of the Volen National Center for Complex Systems. His research focuses on computational neuroscience, integrating dynamical systems theory with experimental data to understand neural mechanisms underlying decision-making, memory, and sensory processing. He holds a Ph.D. from the University of Bristol (UK) and a B.A. from Cambridge University. Before joining Brandeis in 2000, he was at Georgetown University and conducted postdoctoral work in theoretical physics at Oak Ridge National Laboratory. Education: B.A., Cambridge University (1991) Ph.D., University of Bristol (1994) Research Interests: Computational Neuroscience emphasizes modeling neural circuits for short-term/long-term memory, decision-making processes, and the dynamics of neural ensemble activity. His work bridges theoretical approaches (e.g., hidden Markov modeling, spiking neuron networks) with experimental data from cortical and hippocampal systems. He explores how quasistable attractor states enable robust computation and how homeostatic mechanisms stabilize neural activity. Notable Contributions: Developed models explaining how integral feedback control enables robust sequential decision-making, elucidated synaptic mechanisms for spatiotemporal discrimination, and analyzed the role of calcium/calmodulin-dependent protein kinase II (CaMKII) in long-term memory stability. His textbook An Introductory Course in Computational Neuroscience (MIT Press) is widely used in graduate programs. Labs/Teams: Leads the Computational Neuroscience Lab at Brandeis, collaborating with experimentalists to validate theoretical models. Active in interdisciplinary projects involving neurophysiology, systems biology, and mathematical neuroscience.

• Metabolic Dysfunction
• Calcium Signaling
• Liver Diseases
• +۳ مورد دیگر

Mateus Guerra, PhD, is a Senior Staff Scientist at the Yale School of Medicine, Department of Medicine (Digestive Diseases). He holds appointments in Digestive Diseases and is affiliated with the Center for Cellular and Molecular Imaging (CCMI). His research focuses on calcium signaling pathways in liver pathophysiology, metabolic dysfunction-associated steatohepatitis (NASH), and mitochondrial biology. Guerra earned his PhD in Pharmacology from the Federal University of Minas Gerais (2010), with a visiting research stint at Università di Roma La Sapienza (2008), and earlier degrees including an MSc in Biochemical Pharmacology (2004) and BS in Pharmacy (2000). Key research interests include the role of cytosolic calcium in hepatic metabolism, neutrophil-mediated liver injury in alcoholic hepatitis, and lipid droplet cholesterol regulation in NASH. His work integrates molecular biology, cell signaling, and advanced imaging techniques to study liver diseases. Collaborations with prominent researchers like Michael H. Nathanson and Gerald I. Shulman highlight his contributions to translational hepatology. Guerra's lab at the CCMI explores cellular mechanisms linking metabolic stress and liver injury, with recent studies published in Proceedings of the National Academy of Sciences , Cell Metabolism , and Journal of Clinical Investigation . His research has identified novel therapeutic targets for NASH and alcohol-related liver diseases through insights into mitochondrial calcium dynamics and lipid droplet biology. No scientific awards are explicitly listed, but his extensive publication record underscores peer recognition. He advises a collaborative network of researchers but no named students are documented here. Funding sources and grants are not specified in the provided text.

• Metabolic Disorders
• Diabetes Research
• Cardiovascular Biology
• +۳ مورد دیگر

Dongyan Zhang is an Associate Research Scientist in the Department of Endocrinology at Yale School of Medicine, Yale University. Their research focuses on metabolic disorders, diabetes, and cardiovascular biology, with a particular emphasis on insulin resistance mechanisms, mitochondrial function, and therapeutic interventions. Collaborations include work with prominent researchers such as Gerald I. Shulman, Rafael Calais Gaspar, and Mario Kahn. Key research interests include understanding how exercise and pharmacological agents influence metabolic pathways in muscle and liver tissues, as well as investigating the role of lipids and signaling molecules in inflammation and insulin resistance. Recent studies have explored SGLT2 inhibitors’ effects on heart failure, ceramide synthesis inhibitors’ impact on insulin signaling, and calcium-mediated regulation of hepatic metabolism. Education and Affiliations: Primary appointment in Endocrinology; cross-listed in Internal Medicine. Collaborative Work: Frequent collaborations on metabolic and cardiovascular research projects. Publications: Recent work published in Science Advances , Journal of Clinical Investigation , and Cell Metabolism . For inquiries, contact via email: dongyan.zhang@yale.edu .

• Cardiac Physiology
• Cardiac Pathophysiology
• Cardiac Electrophysiology
• +۵ مورد دیگر

Jakub Tomek is a Sir Henry Wellcome Fellow at the University of Oxford, working within the Department of Physiology, Anatomy and Genomics (DPAG) and based in the Zaccolo Laboratory. His research focuses on the intersection of cardiac physiology, computational modeling, and arrhythmia mechanisms. Dr. Tomek's research interests center around cardiac diabetic remodeling, arrhythmogenesis, and pro-arrhythmic drug interactions. He employs a multidisciplinary approach combining whole-heart experiments , subcellular imaging , and advanced computational simulations of human cardiomyocytes. His work bridges experimental cardiology with computational modeling to address critical questions in cardiac electrophysiology and drug safety. His research outputs demonstrate strong trends across cardiac computational modeling, calcium signaling analysis, and arrhythmia mechanisms. The publications reveal a consistent focus on developing computational tools for cardiac research while investigating fundamental mechanisms of cardiac rhythm disorders, particularly in diabetic conditions and post-infarction settings. Sir Henry Wellcome Fellowship - prestigious research award supporting his work on cardiac diabetic remodeling and arrhythmogenesis Dr. Tomek has led the development of several important software tools for cardiac research including ToR-ORd (a computational model of human ventricular myocytes), SparkMaster 2 (for calcium spark analysis), and COSMAS (for cardiac optical mapping analysis). His previous postdoctoral work included positions with Prof. Don Bers at UC Davis, Prof. Neil Herring at Oxford, and Prof. Blanca Rodriguez, focusing on CaMKII function, neuropeptide Y, and computational electrophysiology models. His research group within the Zaccolo Lab focuses on compartmentalized cAMP signaling and its role in cardiac rhythm control, utilizing both experimental and computational approaches to understand fundamental cardiac mechanisms.

Brian D Ackleyمشاهده پروفایل

استاد

• Neurobiology
• Synaptic Development
• Host-Pathogen Interactions
• +۳ مورد دیگر

Brian D Ackley is a Professor in the Department of Molecular Biosciences at the University of Kansas , where he also serves as Co-Director of the Undergraduate Biology Program, Director of the NIH-funded Chemistry-Biology Interface Graduate Training Program (T32), and Campus Coordinator for the Kansas IDeA Network for Biomedical Research Excellence (K-INBRE). His research spans three primary areas: Synapse Dynamics : Investigating adhesion proteins (e.g., nidogen, LAR receptor) and calcium channels in synapse formation/elimination balance Neurodegenerative Disease Models : Developing early-onset C. elegans models for Alzheimer's and tauopathies, uncovering non-amyloid mechanisms in familial AD Host-Pathogen Evolution : Analyzing genetic adaptations in C. elegans isolates to understand immune response diversity His work utilizes Caenorhabditis elegans as a model system with genetic mapping, fluorescent imaging, and collaborative biochemical approaches. Publications demonstrate interdisciplinary focus across Neuroscience , Molecular Genetics , and Developmental Biology . Teaching includes advanced neurobiology courses and research mentorship for trainees at all levels. Education : PhD in Neuroscience, Northwestern University (2001) B.A. in Chemistry and Psychology, Virginia Tech (1994) Postdoctoral Training at University of Illinois Chicago and UC Santa Cruz Research Highlights : Discovered calcium channel's role in suppressing synaptic overgrowth from adhesion protein loss Elucidated Flamingo receptor's non-autonomous regulation of inhibitory neuron synapses Developed first C. elegans models showing age-dependent synaptic degeneration Collaborated with Wolfe and Gamblin labs to challenge amyloid hypothesis in Alzheimer's Technical Expertise : Genetic manipulation, fluorescent protein imaging, transcriptional profiling, and cross-species comparative analysis.

Javier Diaz Alonsoمشاهده پروفایل

استادیار

• Neuroscience
• Neurobiology
• Cellular Neuroscience
• +۳ مورد دیگر

Javier Diaz Alonso, PhD, is an Assistant Professor in the Department of Anatomy & Neurobiology at the University of California, Irvine School of Medicine. His research focuses on synaptic transmission, neurodevelopment, and the role of cannabinoid receptors in neural processes. He is involved in NIH-funded research (R01 MH117139) exploring mechanisms of synaptic plasticity, receptor signaling, and neurogenesis. His work integrates molecular biology, cellular neuroscience, and in vivo models to study neurological processes and disorders. Key research interests include the regulation of AMPA receptors, synaptic plasticity, and the impact of endocannabinoid systems on brain development and function. Recent studies have addressed the roles of CaMKII/NMDA receptor complexes and CB1/CB2 cannabinoid receptors in synaptic transmission and neurodevelopmental outcomes. Publications highlight contributions to understanding synaptic protein interactions (e.g., α2δ1-GluA1 complexes), myelination pathways (TACE/ADAM17), and the molecular mechanisms governing synaptic stability. Collaborative projects include investigations into phase separation of synaptic proteins and the functional implications of genetic variants in neurodevelopmental disorders. Funding and grants: NIH R01 MH117139 supports ongoing studies on neural signaling pathways. His work has implications for treating epilepsy, memory disorders, and neurodegenerative conditions through targeted modulation of synaptic and endocannabinoid systems.

Suzanne Eldridgeمشاهده پروفایل

مدرس ارشد

• Musculoskeletal Regenerative Medicine
• Osteoarthritis Treatment
• Cartilage Homeostasis
• +۳ مورد دیگر

Dr. Suzanne Eldridge - Senior Lecturer of Musculoskeletal Regenerative Medicine Dr. Eldridge is a molecular biologist with an engineering background, focusing on musculoskeletal tissue regeneration. She is affiliated with Queen Mary University of London's Faculty of Medicine and Dentistry, specifically the Experimental Medicine and Rheumatology department. Her research centers on developing therapies to prevent cartilage breakdown and enhance repair in osteoarthritis and trauma, leveraging discoveries like the role of Agrin in cartilage homeostasis. Education & Research Focus : Eldridge's PhD work identified Agrin's role in cartilage health. Her current projects include exploring Wnt signaling, ROR2 blockade, and exosome-based therapies for cartilage regeneration. She advises PhD students Aida Barawi and Zara Khan. Grants & Collaborations : Supported by Versus Arthritis, Rosetrees Trust, MRC, and UCB. She offers research opportunities for undergraduate, MSc, and PhD students through her lab, The ReGen Lab (@TheReGenLab). Lab & Team : The lab focuses on translational research, combining molecular biology and engineering approaches to address musculoskeletal challenges. Collaborations involve clinical and industry partners to advance therapeutic technologies.

Kathy W. Nordeenمشاهده پروفایل

استاد

• Neural Plasticity
• Vocal Learning
• Avian Neurobiology
• +۴ مورد دیگر

Kathy Nordeen is a Professor of Brain and Cognitive Sciences and Neuroscience at the University of Rochester. Her research examines neural mechanisms of vocal learning and plasticity in songbirds, using molecular, pharmacological, and behavioral approaches to understand how experience shapes neural circuits during sensitive periods. Key research areas include: Role of basal ganglia pathways and dopaminergic systems in vocal learning Biochemical and synaptic changes underlying auditory memory formation Neurogenesis and dendritic spine dynamics during sensitive periods NMDA receptor regulation in developmental and adult plasticity Neural basis of species-specific vocal preferences Her laboratory has demonstrated that deafening-induced vocal deterioration can be reversed by manipulating basal ganglia-forebrain circuits, revealing therapeutic targets for neural repair. Current projects investigate dopaminergic signaling during song tutoring and CaMKII activation in auditory memory formation. Research has been supported by the National Institute of Mental Health, National Science Foundation, Schmitt Foundation, and Whitehall Foundation.

Joseph P. Stainsمشاهده پروفایل

استاد

• Bone Biology
• Connexin43 Signaling
• Osteoblast Differentiation
• +۳ مورد دیگر

Joseph P. Stains, PhD, is a Professor in the Department of Orthopaedics with secondary appointment in Physiology at University of Maryland School of Medicine. He leads the Division of Musculoskeletal Science and maintains affiliations with multiple research centers including the Center for Research on Aging and Center for Stem Cell Biology. Education: B.S. in Molecular & Cell Biology (1994), PhD in Biochemistry (2000) from Penn State University Appointments: Postdoc at Washington University (2001-2004), then continuously at University of Maryland since 2004 Dr. Stains' research focuses on bone cell signaling through connexin43-containing gap junctions , examining how intercellular communication coordinates osteoblast differentiation and osteocyte mechanotransduction . His work mechanistically links cytoskeletal dynamics to sclerostin regulation via NOX2-ROS-TRPV4-CaMKII pathways. His lab has produced over 65 peer-reviewed publications with recent emphasis on microtubule rheostats and Ca²⁺-dependent bone remodeling . Funding includes NIH R01 grants (2013-2025), DoD , and Maryland Stem Cell Research Fund awards. Scientific Leadership: ASBMR Fellow (2020), NIH Study Section Member Academic Service: Graduate Council, School of Medicine Council, Course Director for GPLS 645