Javier Diaz Alonso

Javier Diaz Alonso, PhD, is an Assistant Professor in the Department of Anatomy & Neurobiology at the University of California, Irvine School of Medicine. His research focuses on synaptic transmission, neurodevelopment, and the role of cannabinoid receptors in neural processes. He is involved in NIH-funded research (R01 MH117139) exploring mechanisms of synaptic plasticity, receptor signaling, and neurogenesis. His work integrates molecular biology, cellular neuroscience, and in vivo models to study neurological processes and disorders.

Key research interests include the regulation of AMPA receptors, synaptic plasticity, and the impact of endocannabinoid systems on brain development and function. Recent studies have addressed the roles of CaMKII/NMDA receptor complexes and CB1/CB2 cannabinoid receptors in synaptic transmission and neurodevelopmental outcomes.

Publications highlight contributions to understanding synaptic protein interactions (e.g., α2δ1-GluA1 complexes), myelination pathways (TACE/ADAM17), and the molecular mechanisms governing synaptic stability. Collaborative projects include investigations into phase separation of synaptic proteins and the functional implications of genetic variants in neurodevelopmental disorders.

Funding and grants: NIH R01 MH117139 supports ongoing studies on neural signaling pathways. His work has implications for treating epilepsy, memory disorders, and neurodegenerative conditions through targeted modulation of synaptic and endocannabinoid systems.