جست‌وجوی استاد و پژوهشگر

Cahir O'Kaneمشاهده پروفایل

استاد

• Drosophila neuronal cell biology
• Neurodegenerative diseases
• Hereditary Spastic Paraplegia (HSP)
• +۲ مورد دیگر

Professor Cahir O'Kane is a faculty member at the Department of Genetics , University of Cambridge. He studied Genetics as an undergraduate in Cambridge, earned a PhD in bacterial genetics at Trinity College Dublin, and conducted postdoctoral work at the University of Basel, where he developed enhancer trapping in Drosophila . His research focuses on subcellular neuronal function and dysfunction using Drosophila as a model organism, particularly the role of axonal endoplasmic reticulum (ER) in hereditary spastic paraplegia (HSP). He actively contributes to undergraduate teaching in cell biology and genetics and serves as a Director of Studies at Churchill College. His work leverages Drosophila to explore ER-shaping proteins implicated in HSP, such as those causing axonal ER continuity gaps. Current projects involve screening tools for ER formation genes, light/electron microscopy analyses, and physiological impacts of ER disruption. He collaborates with the Virtual Fly Brain consortium for integrating Drosophila brain data. He advocates for sustainable funding of scientific resources like FlyBase and has supported efforts to relocate FlyBase operations to Cambridge amid NIH funding cuts. His team has received Marie-Sklodowska-Curie Horizon 2020 awards for research on ER dynamics (Dr. Lu Zhao, Dr. JJ Perez Moreno).

• Neuronal Cell Biology
• Axonal Transport
• Cytoskeleton Dynamics
• +۷ مورد دیگر

Shaul Yogev is an Associate Professor in the Department of Neuroscience and the Department of Cell Biology at Yale School of Medicine. He is affiliated with the Interdepartmental Neuroscience Program and the Wu Tsai Institute, reflecting his interdisciplinary research in neuronal cell biology. PhD, Weizmann Institute of Science, Molecular Genetics Postdoctoral Training, Stanford University with Kang Shen BSc and MSc, Paris VII University, France Dr. Yogev's research focuses on the fundamental mechanisms governing neuronal architecture and transport. His lab investigates how the neuronal cytoskeleton, particularly microtubules, is organized and how this organization enables polarized cargo transport essential for synaptic maintenance over long distances. Using C. elegans as a model system, his team employs advanced live imaging and genetic tools to study microtubule nucleation, motor protein navigation, and organelle distribution. Their work has significant implications for understanding neurodegenerative diseases where axonal transport is compromised. His recent publications reveal a consistent focus on microtubule dynamics, motor-cargo interactions, and organelle transport, with key contributions to understanding mitochondrial trafficking, spectrin transport, and ER stress in neurons. These studies employ cutting-edge imaging and quantitative analysis techniques, positioning his lab at the forefront of cellular neuroscience. Human Frontiers Fellowship Haim Holzman memorial prize for academic excellence and scientific accomplishments Dr. Yogev leads an active research program with strong collaborative ties, particularly with Marc Hammarlund and Pietro De Camilli. His lab has developed novel imaging methodologies and contributed significantly to understanding how neurons maintain their complex structure and function. He is involved in graduate education through the Biological and Biomedical Sciences Program and the Interdepartmental Neuroscience Program at Yale. Dr. Yogev's work is conducted within the vibrant neuroscience community at Yale, including the Wu Tsai Institute and the Kavli Institute for Neuroscience, where his research on cytoskeletal dynamics contributes to broader efforts in understanding brain function and disease.

Ginny G. Faríasمشاهده پروفایل

استاد

• Neuronal organelle dynamics
• Endoplasmic reticulum organization
• Neuronal polarity
• +۳ مورد دیگر

Dr. Ginny G. Farías is an independent group leader and faculty member at Utrecht University , Faculty of Science, within the Department of Biology, Division of Cell Biology . She heads the Neuronal Organelle Dynamics group, focusing on how sub-cellular organization of organelles underpins neuronal development and function. Education & Training: BSc in Biology – Pontifical Catholic University of Chile PhD in Cellular and Molecular Biology – Pontifical Catholic University of Chile (2009) Post-doctoral fellowship – National Institutes of Health (NIH), USA, with Dr. Juan S. Bonifacino (2010-2016) Research Focus: Dr. Farías combines advanced live-cell imaging, genetic engineering and biochemical approaches to dissect how the endoplasmic reticulum (ER) and other organelles are positioned and communicate within neurons. Her lab investigates ER tubule and cisternae organization, membrane contact sites, polarized protein trafficking, local mRNA translation and the impact of organelle disorganization on neurological disease. Funding & Recognition: She has secured highly competitive grants including an NWO-VIDI (2018) and an ERC Starting Grant (2020) . In 2024 she was featured as a Cell Scientist to Watch by Journal of Cell Science. Laboratory & Team: The group currently comprises 7 PhD students, 2 post-doctoral researchers and 1 master student, all working at the intersection of cell biology, neurobiology and biophysics.

• Cell Specification and Differentiation
• Cellular/Molecular/Developmental Neuroscience
• Neural Degeneration and Repair
• +۱ مورد دیگر

Hynek Wichterle is a Professor holding joint appointments in the Departments of Pathology & Cell Biology, Neuroscience (in Neurology), and Rehabilitation and Regenerative Medicine at Columbia University Medical Center. He serves as Co-Director of the Columbia Stem Cell Initiative and Vice-Chief of the Division of Regenerative Medicine in the Department of Rehabilitation & Regenerative Medicine. He also holds the administrative title of Co-Director of the Motor Neuron Center. Dr. Wichterle received his M.S. degree from Charles University in Prague and his Ph.D. degree from The Rockefeller University. He trained at Columbia University, where he became an assistant professor in 2004 and associate professor in 2012 before achieving his current professorship. Wichterle's research focuses on modeling nervous system development in vitro using stem cell technologies. His laboratory has pioneered efficient methods for differentiating pluripotent embryonic stem cells into specific subtypes of spinal motor neurons and interneurons. His work combines stem cell differentiation with CRISPR-based genome editing and inducible transgene expression to decode transcriptional programs controlling neural development. A major focus of his research involves using both mouse and human pluripotent stem cells to model motor neuron degenerative diseases like amyotrophic lateral sclerosis (ALS), with the goal of discovering new neuroprotective drugs. Analysis of his recent publications reveals a consistent focus on developmental neuroscience, stem cell biology, and neurodegenerative disease modeling. His work spans molecular mechanisms of neuronal specification, chromatin regulation, and therapeutic applications for motor neuron diseases. Over time, his research has evolved from foundational work on motor neuron differentiation to increasingly sophisticated models of disease mechanisms and drug discovery approaches. Dr. Wichterle has made significant contributions to understanding the transcriptional programs that control motor neuron identity and function. His laboratory has assembled global maps of genomic regulatory elements controlling motor neuron expression programs, effectively decoding the 'syntax and grammar' of the transcription factor language that specifies neuronal cell identity during embryonic development. His research program benefits from extensive collaborations across multiple disciplines, including molecular biology, genomics, and therapeutic development. The laboratory's unique stem cell-based screening platforms have enabled the identification of compounds that protect motor neurons from degeneration, bridging basic science with potential clinical applications for ALS and related disorders.

Julie Hollienمشاهده پروفایل

استاد

• Endoplasmic Reticulum Stress
• Unfolded Protein Response
• RNA Decay
• +۴ مورد دیگر

Julie Hollien is a Professor of Biological Sciences at the University of Utah, leading research on endoplasmic reticulum (ER) stress mechanisms and their implications in neurodegenerative diseases. Her work bridges molecular cell biology with disease pathology, focusing on protein homeostasis pathways critical in conditions like Huntington's disease and Alzheimer's. Her academic background includes: B.A. from Reed College Ph.D. from the University of California, Berkeley Dr. Hollien's research program investigates the Unfolded Protein Response (UPR) and Regulated Ire1-Dependent Decay (RIDD), revealing how mRNA decay pathways regulate lysosome positioning and protein aggregate clearance. Her lab demonstrated that RIDD-mediated degradation of Blos1 mRNA triggers perinuclear lysosome clustering, enhancing clearance of disease-associated aggregates like mutant Huntingtin. This work establishes critical links between ER stress, RNA regulation, and neurodegeneration using Drosophila and mammalian models. Analysis of her publication trends shows sustained focus on ER stress adaptation mechanisms, with recent work expanding into therapeutic implications for neurodegenerative and metabolic disorders. Her articles consistently explore intersections between RNA biology, organelle dynamics, and disease pathogenesis, demonstrating translational relevance from fundamental mechanisms to disease models. She directs an active research laboratory at the University of Utah that employs molecular, cellular, and genetic approaches to dissect stress response pathways. Her team investigates how RNA decay mechanisms influence cellular physiology during proteotoxic stress, with ongoing work exploring therapeutic modulation of these pathways for neurodegenerative conditions.

Paul Meakinمشاهده پروفایل

دانشیار

• Cardiovascular Disease
• Type 2 Diabetes
• Alzheimer's Disease
• +۳ مورد دیگر

Dr. Paul Meakin is a BHF Intermediate Basic Science Research Fellow and Associate Professor at the University of Leeds , affiliated with the School of Medicine . His work bridges cardiovascular disease, Type 2 diabetes, and Alzheimer's disease, focusing on the ß-secretase enzyme (BACE1) as a therapeutic target. Education: MSci in Biochemistry and Biological Chemistry, University of Nottingham (2004) PhD in Molecular Physiology, University of Dundee (2009) Research Interests: Cardiovascular-metabolic-neurodegenerative intersections, BACE1 enzyme regulation , endothelial cell dysfunction, and vascular remodeling in diabetes. His lab investigates how BACE1 inhibition can prevent vascular complications in metabolic diseases. Publications Trends: His 15 most recent articles (2025-2013) center on BACE1's role in vascular health, diabetes-induced atherosclerosis, fibrosis in systemic sclerosis, and amyloid-related pathologies. They explore in vivo models, signaling pathways (Wnt/β-catenin, Notch), and translational strategies like repurposing BACE1 inhibitors for cardiometabolic applications. Scientific Recognition: Nick Hales Young Investigator Award (2017, 2014) Professional Leadership: Co-lead of the Physiology Society’s Metabolic Physiology Theme (2019-2022) and committee member of the British Microcirculation Society (2019-2022). Research Groups: Affiliated with the Leeds Institute of Cardiovascular and Metabolic Medicine and the Multidisciplinary Cardiovascular Research Centre , focusing on Discovery and Translational Science in cardiometabolic health.

Jordi Magraneمشاهده پروفایل

دانشیار

• Neuroscience
• Mitochondrial Biology
• Neurodegenerative Diseases
• +۵ مورد دیگر

Jordi Magrane is an Associate Professor of Research in Neuroscience at the Brain and Mind Research Institute, Weill Cornell Medical College, a position he has held since 2017. His research primarily focuses on the role of mitochondrial dysfunction in neurodegenerative diseases, with particular emphasis on Friedreich's ataxia, amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. Dr. Magrane earned his B.S. and Ph.D. from the University of Barcelona, Spain, completing his doctoral studies in the Faculty of Biology in 2000. His educational background provided the foundation for his current research in cellular and molecular neuroscience. Dr. Magrane's research interests center on mitochondrial biology in neurodegenerative conditions , with specific focus on: Mitochondrial dynamics and bioenergetics in neuronal cells Role of mitochondrial dysfunction in Friedreich's ataxia pathogenesis Mechanisms of neuroprotection through mitochondrial targeting Imaging techniques for studying neuronal activity and mitochondrial function Cellular mechanisms underlying synaptic deficits in neurodegenerative diseases Analysis of Dr. Magrane's publication record reveals a consistent research trajectory focused on the intersection of mitochondrial function and neurodegeneration. His work spans multiple disease models including Friedreich's ataxia (KIKO mouse model), ALS (SOD1 models), and Alzheimer's disease. A significant portion of his recent work has centered on developing therapeutic approaches targeting mitochondrial electron transport to rescue neuronal function in ischemic injury and genetic neurodegenerative conditions. Dr. Magrane has received research funding as Principal Investigator for multiple projects including: "Postnatal development of the cerebellar circuitry in the KIKO mouse model of Friedreich's ataxia" (Friedreich's Ataxia Research Alliance, 2024-2026) "Selective frataxin deficiency in glial cells in vivo in novel mouse models of Friedreich's ataxia" (2024-2026) "Cell & non-cell autonomous effects of frataxin deficiency in FA pathophysiology" (Muscular Dystrophy Associations of America, Inc., 2019-2025) Within the Brain and Mind Research Institute at Weill Cornell Medical College, Dr. Magrane leads a research team investigating the cellular and molecular mechanisms of neurodegenerative diseases, with particular emphasis on developing imaging techniques to study mitochondrial dynamics and neuronal function in vivo. His laboratory utilizes transgenic mouse models, advanced imaging technologies, and molecular approaches to understand and potentially treat neurological disorders.

• Cell Biology
• Neurobiology
• Biophysics
• +۴ مورد دیگر

Dr. G.C. (Ginny) Farias Galdames is an Assistant Professor at the Faculty of Science , Utrecht University , affiliated with the Cell Biology, Neurobiology and Biophysics research group. Her work focuses on the dynamics of cellular organelles in neurons , particularly the interactions between the endoplasmic reticulum (ER) and lysosomes , mechanisms of polarized protein secretion , and organelle transport .

Elena Kosloverمشاهده پروفایل

دانشیار

• Theoretical Biophysics
• Intracellular Transport
• Organelle Dynamics
• +۳ مورد دیگر

Elena Koslover is Associate Professor of Physics at UC San Diego, holding a PhD from Stanford University (2013). Her research develops physical models of intracellular processes in eukaryotic cells, focusing on transport mechanisms, organelle dynamics, and cellular architecture. Research investigates how components navigate cells through diffusion, motor-driven transport, and network effects. Current projects examine endoplasmic reticulum as a distribution network, mitochondrial positioning in neurons, and motor-protein mechanics. The Koslover Group employs theoretical modeling and simulations to quantify intracellular kinetics. Group includes graduate students and postdoctoral scholars studying organelle networks, diffusion in confined spaces, and intracellular search processes. Outreach includes directing the Young Scientists Club for elementary students.

• Neuroscience
• Genetics
• Metabolic Disorders
• +۳ مورد دیگر

Roman Chrast is a Lecturer at the School of Life Sciences, EPFL, and serves as Head of Research Core Facilities under the Deanship SV. His roles include overseeing research infrastructure and teaching life sciences engineering courses. He holds a PhD in Life Sciences from the University of Geneva and a CAS in Management of Medtech, Biotech, and Pharma Ventures from EPFL. Research interests focus on metabolic interactions in myelinating Schwann cells, genetic neuropathies (e.g., Charcot-Marie-Tooth), and mitochondrial dysfunction in neurological diseases. His work bridges basic science and translational medicine, exploring molecular mechanisms underlying axonal degeneration and glial cell biology. Publications highlight contributions to understanding Schwann cell metabolism, mitochondrial dynamics, and gene therapy approaches for neuropathies. His administrative roles involve coordinating core facilities to support interdisciplinary research in life sciences.

Christian Schultzمشاهده پروفایل

استاد

• Axonal Plasticity
• Neuronal Polarity
• Organelle Membrane Contacts
• +۳ مورد دیگر

Christian Schultz is a Professor in Neuroanatomy at the Medical Faculty Mannheim, part of Heidelberg University. His research focuses on axonal compartment plasticity, particularly the axon initial segment (AIS), and membrane contacts between organelles like peroxisomes and the endoplasmic reticulum (ER). He investigates how AIS structural changes impact neuronal excitability using in vivo models like the mouse whisker-to-barrel pathway. Recent studies revealed rapid AIS remodeling within hours of environmental enrichment. Future work includes live imaging of AIS dynamics and exploring peroxisome-ER interactions in neurodegeneration, especially retinal pathologies. Key research areas include: Developmental mechanisms of axonal polarity Role of ACBD5-VAPB protein interactions in peroxisome-ER contacts Functional significance of axon-carrying dendrites in hippocampal ensembles His lab employs advanced techniques such as live reporter mouse lines for in vivo imaging and genetic models to study neurodegenerative processes. Current projects aim to untangle AIS plasticity's role in sensory processing and elucidate how organelle membrane contacts influence neuronal health. Notable findings include identifying ACBD5 as a critical mediator of peroxisome-ER contacts and demonstrating bidirectional AIS plasticity linked to homeostatic regulation of neuronal excitability.

Niamh O'Sullivanمشاهده پروفایل

دانشیار

• Motor neuron diseases
• Hereditary spastic paraplegia
• Endoplasmic reticulum organization
• +۶ مورد دیگر

Niamh O'Sullivan is an Associate Professor in the School of Biomolecular and Biomedical Science at University College Dublin (UCD), where she has been a faculty member since 2013. She previously served as Head of Genetics at UCD from 2017-2021. Dr. O'Sullivan leads a research laboratory focused on understanding motor neuron organization and function, with particular emphasis on neurodegenerative diseases. Dr. O'Sullivan earned her BA in Genetics from Trinity College Dublin in 2001, followed by a PhD in Science, Biochemistry, and Biotechnology from University College Dublin in 2005. Her postdoctoral training included positions at UCD (2005-2009), University of Cambridge as a Marie Curie Fellow (2009-2012), and Imperial College London as a Junior Research Fellow (2012-2013). Her research program specializes in using Drosophila melanogaster (fruit fly) to model neurodegenerative diseases, particularly hereditary spastic paraplegia (HSP) and optic atrophy. She investigates how endoplasmic reticulum (ER) organization and mitochondrial function contribute to neuronal health and degeneration. Her work has revealed critical connections between ER-shaping proteins, mitochondrial dynamics, and axonal integrity in motor neurons. Analysis of Dr. O'Sullivan's recent publications shows a clear progression from fundamental studies of ER and mitochondrial organization in neurons toward translational research exploring therapeutic interventions for neurodegenerative conditions. Her 2022-2025 work increasingly focuses on identifying potential treatments, including lipid-regulating compounds for HSP and understanding mitochondrial dysfunction in optic atrophy. Wellcome Trust-SFI-HRB Seed Award in Science (2016) Marie Curie Fellowship (2009-2012) Junior Research Fellowship at Imperial College London (2012-2013) Dr. O'Sullivan has supervised numerous graduate students including Philippa Fowler (completed PhD), Dwayne Byrne, and Elena Garcia. She has received significant research funding including a Wellcome Trust/National Institutes of Health joint PhD studentship for her student Dwayne Byrne. Her teaching responsibilities include coordinating Epigenetics and Neuroproteinopathies modules at UCD since 2014. The O'Sullivan Lab maintains an active research program with multiple undergraduate and graduate students, international collaborators, and regular presentations at major neuroscience conferences. The O'Sullivan Lab, based at the Conway Institute at UCD, utilizes advanced imaging techniques, Drosophila genetics, and mammalian cell culture models to investigate the cellular mechanisms underlying neurodegenerative diseases. The lab has developed several novel disease models and quantitative methods for analyzing organelle morphology, particularly focusing on the endoplasmic reticulum and mitochondria in neurons.

Graham Knottمشاهده پروفایل

استاد مدعو

• Brain Ultrastructure
• Electron Microscopy
• Neuronal Plasticity
• +۳ مورد دیگر

Graham Knott is an Adjunct Professor at the École Polytechnique Fédérale de Lausanne (EPFL) and heads the Bioelectron Microscopy Core Facility (PTBIOEM) within the School of Life Sciences (SV). His research focuses on brain ultrastructure, neuronal plasticity, and advanced electron microscopy techniques, particularly in 3D imaging of biological samples. He leads a platform integrating diverse electron imaging technologies and preparation methods to support EPFL researchers in neurobiological studies. Knott's work bridges microscopy innovation with neuroscientific applications, emphasizing structural analysis of synapses, axons, and neuropathological processes like α-synuclein aggregation. He collaborates closely with interdisciplinary teams to advance understanding of neural circuitry and disease mechanisms. His academic roles include teaching in the Life Sciences Engineering program, specifically the 'Methods: from disease models to therapy' course, which combines theoretical knowledge with hands-on platform training. Key research areas include: 3D electron microscopy of neural tissues Imaging synaptic plasticity and axonal regeneration Mechanistic studies of neurodegenerative proteinopathies Development of correlative microscopy workflows Recent publications highlight advancements in ultrastructural analysis, including studies on α-synuclein-induced metabolic changes, axoneme dynamics, and biofilm-like structures in Mycobacterium tuberculosis.

Gulcin Pekkurnazمشاهده پروفایل

دانشیار

• Neurobiology
• Mitochondrial Biology
• Neuronal Metabolism
• +۳ مورد دیگر

Gulcin Pekkurnaz is an Associate Professor in the Department of Neurobiology at the University of California San Diego (UCSD). Her research focuses on understanding how mitochondrial function is coupled with neuronal metabolism, particularly in the context of neurological diseases. Her lab employs interdisciplinary approaches including molecular biology, mouse genetics, metabolic flux analysis, and advanced imaging techniques like super-resolution microscopy. Key research interests include mitochondrial dynamics, energy homeostasis at synapses, and the role of mitochondria in neurodegenerative diseases. She investigates how metabolic requirements vary across neuronal subtypes and how mitochondrial dysfunction contributes to disease pathogenesis. Her work integrates systems biology modeling with experimental methods to study mitochondria-endoplasmic reticulum contact sites and calcium signaling. Her lab utilizes cutting-edge tools such as deep learning-based super-resolution imaging and computational modeling to unravel novel metabolic pathways. Current projects explore O-GlcNAcylation's role in mitochondrial plasticity, glycolytic metabolon assembly, and glucose-dependent mitochondrial trafficking mechanisms. Contact: gpekkurnaz@ucsd.edu

• Neuroscience
• Cell Biology
• Membrane Biology
• +۵ مورد دیگر

Volker Haucke is a prominent Professor at the Leibniz Research Institute for Molecular Pharmacology (FMP) in Berlin, leading a research group focused on cellular and neuronal membrane dynamics. His laboratory investigates fundamental processes of membrane remodeling, organelle function, and synaptic organization with particular emphasis on lipid signaling pathways in neuronal cells. Haucke's research interests span neuroscience, cell biology, membrane dynamics, synapse biology, lipid signaling, organelle communication, and neurodegenerative disease mechanisms . His work bridges molecular mechanisms with cellular function, particularly examining how lipid-protein interactions govern membrane organization in neurons. His recent publications reveal a strong focus on lysosomal lipid homeostasis, presynaptic assembly, membrane remodeling mechanisms, and the role of lipid signaling in neurodegenerative conditions including ALS. The research employs advanced techniques including structural biology, biochemical analysis, and cellular imaging to unravel molecular mechanisms. Gottfried Wilhelm Leibniz Prize 2025 recipient from the Deutsche Forschungsgemeinschaft (DFG) Organizer of international conferences including the Molecular Basis of Membrane Remodeling and Organization Principal investigator securing ERC and DFG funding for neuroscience research Haucke actively mentors postdoctoral researchers and maintains a vibrant research program with current projects examining presynapse formation and ALS mechanisms. His laboratory is recognized as a certified green lab committed to sustainable research practices. He frequently collaborates with researchers across Europe, as evidenced by his participation in international conferences and co-authorship with researchers from multiple institutions.