Graham Knott

Graham Knott is an Adjunct Professor at the École Polytechnique Fédérale de Lausanne (EPFL) and heads the Bioelectron Microscopy Core Facility (PTBIOEM) within the School of Life Sciences (SV). His research focuses on brain ultrastructure, neuronal plasticity, and advanced electron microscopy techniques, particularly in 3D imaging of biological samples. He leads a platform integrating diverse electron imaging technologies and preparation methods to support EPFL researchers in neurobiological studies.

Knott's work bridges microscopy innovation with neuroscientific applications, emphasizing structural analysis of synapses, axons, and neuropathological processes like α-synuclein aggregation. He collaborates closely with interdisciplinary teams to advance understanding of neural circuitry and disease mechanisms. His academic roles include teaching in the Life Sciences Engineering program, specifically the 'Methods: from disease models to therapy' course, which combines theoretical knowledge with hands-on platform training.

Key research areas include:

• 3D electron microscopy of neural tissues
• Imaging synaptic plasticity and axonal regeneration
• Mechanistic studies of neurodegenerative proteinopathies
• Development of correlative microscopy workflows

Recent publications highlight advancements in ultrastructural analysis, including studies on α-synuclein-induced metabolic changes, axoneme dynamics, and biofilm-like structures in Mycobacterium tuberculosis.