Zhang Chongyi

Zhang Chongyi is a Researcher at the Institute of Biochemistry, Academia Sinica, with a joint appointment as Professor at the Institute of Biochemical Sciences, National Taiwan University since 2020. His research focuses on protein structure-function relationships, particularly in intracellular protein degradation machinery like the Lon protease, and the development of small molecule inhibitors targeting these systems.

His research expertise spans structural biology techniques including

• Protein crystallization
• Biochemical/biophysical analysis
• Single-molecule electron microscopy

Key areas involve autophagy, macroautophagy, and proteasome inhibition mechanisms. Recent work explores structural determinants of protease function and drug design applications in both viral and bacterial contexts.

Scientific Awards include

• 2023 Outstanding Research Award, National Science Council
• 2022 Deepening Project Grant, Academia Sinica

Advising and collaborative research involve structural studies of proteases, with co-authorships on 16+ major publications between 2006-2025. His work has been cited >13,000 times according to ResearchGate.

The article portfolio (15 recent publications) reveals expertise in

• Structural analysis of proteolytic machines
• Allosteric activation mechanisms
• Viral protease inhibition
• Drug development pipelines
• Protein degradation in disease contexts
• Structural biology of macromolecular complexes