Chen Ruihua

Chen Ruihua is a Distinguished Research Fellow at the Institute of Biochemistry, Academia Sinica. He holds a Ph.D. from Michigan State University and has been affiliated with leading institutions including National Taiwan University College of Medicine and University of California, San Francisco. His research focuses on protein degradation pathways, exosome secretion, and their roles in cancer signaling and tumor microenvironment regulation.

Education

• Ph.D., Michigan State University (1987–1991)
• Master, Institute of Biochemical Sciences, National Taiwan University (1983–1985)
• Bachelor of Science, Department of Agricultural Chemistry, National Taiwan University (1979–1983)

Research Interests

• Regulation of lysosomal degradation vs. exosome secretion in cancer
• Proteasomal and lysosomal targeting of oncogenic proteins
• Role of biomolecular condensates in cancer metabolism

Key Contributions

• 2023: Mechanism of PAICS ubiquitination in purinosome assembly
• 2023: TRABID inhibition as anti-tumor immunity strategy
• 2021: VPS34 ubiquitination in autophagy
• 2011: PML regulation in prostate cancer progression

Academic Leadership

• Distinguished Research Fellow, Academia Sinica (2012–present)
• Professor, National Taiwan University (2003–2006)
• Deputy Director, Institute of Biochemistry (2011–2014)
• Research Fellow, Academia Sinica (2006–2012)