معرفی
Irene Nga Wing Lee is a Professor in the Department of Chemistry at Case Western Reserve University. Her research focuses on Biochemistry, Bio-Organic Chemistry, and Medicinal Chemistry, with a particular emphasis on metabolic enzymes critical for cellular functions like protein turnover. Using molecular cloning, mutagenesis, organic synthesis, and enzyme kinetics, she investigates mechanisms of ATP-dependent proteases, notably the Lon protease.
- Education:
- B.S. in Chemistry and B.A. in Biology, University of Toledo (1988)
- Ph.D. in Biochemistry, Pennsylvania State University (1995)
- Contact:
- Email: ixl13@case.edu
- Office: Millis G24A
- Phone: 216.368.6001
Her work on Lon protease explores its ATPase and proteolytic sites, aiming to link molecular mechanisms to mitochondrial diseases (e.g., ocular myopathy) and antimicrobial development. Recent publications highlight studies on adenine-specific conformational changes, translesion DNA synthesis dynamics, and ATP hydrolysis timing in Lon.
For further details, refer to her full description below.
