Yusheng Guo

Yusheng Guo is a Research Fellow in the Department of Digestive Diseases at the Yale School of Medicine. His research focuses on viral pathogenesis with a particular emphasis on rotavirus-host interactions. He investigates how cell surface glycans, mitochondrial biology, and cholesterol metabolism influence viral infection and immune responses. Guo holds a Ph.D. from Ohio State University, where he studied under Dr. Anastasia Vlasova.

His research interests include:

• Virology (Rotavirus A/C strains, zoonotic viruses)
• Cell biology (glycan receptors, mitochondrial signaling)
• Innate immunity (host defense mechanisms)
• Cholesterol metabolism in viral replication

Recent work highlights his exploration of:

• Role of mitochondrial dynamics in macrophage inflammation
• Host-glycan mediated antiviral defenses
• Porcine intestinal enteroids as infection models

No scientific awards are listed, though his contributions span 8 peer-reviewed articles since 2020. He collaborates with leading virology groups and employs advanced organoid culture techniques in his research.