معرفی
Xin Tian is an Associate Research Scientist in Medicine (Nephrology) at Yale School of Medicine, affiliated with the Department of Medicine (Nephrology) and the Somlo Laboratory. He holds a Master of Science and MD from China Medical University (1996). His research focuses on polycystic kidney disease (PKD), particularly ADPKD, investigating molecular mechanisms involving polycystin proteins, signaling pathways (e.g., IRE1α-XBP1), and therapeutic interventions. Collaborations include key figures like Stefan Somlo, Yiqiang Cai, and Ke Dong. His work has revealed modifiers of cyst progression (e.g., GLIS3, GLIS2) and demonstrated reversibility of liver cysts via PKD2 re-expression. Recent studies explore chemical modulation of ER stress pathways and trafficking of polycystin-2. His findings contribute to understanding PKD pathogenesis and potential therapies.
- Education: MS & MD (China Medical University, 1996)
- Research Themes: ADPKD mechanisms, polycystin signaling, therapeutic targets
- Key Collaborations: Somlo Lab, Cai Lab, Fedeles Lab
Publications emphasize functional studies of polycystin proteins and translational approaches to cyst inhibition. No formal advisees listed, but extensive co-authorship with graduate/postdoc researchers.