معرفی
Ke Dong, MD, MS, is a Research Scientist in the Department of Internal Medicine at Yale School of Medicine, specializing in nephrology and kidney disease research. His primary affiliation is with the Somlo Laboratory, focusing on polycystic kidney disease (PKD) mechanisms and therapeutic strategies. Dong holds an MD from Fourth Military Medical University (1986) and an MS from Showa University School of Medicine (1996).
His research interests center on understanding polycystin protein signaling, cyst progression in ADPKD, and developing novel therapies targeting cellular pathways. Key collaborations include work with Stefan Somlo, Yiqiang Cai, and Sorin Fedeles. Recent studies highlight breakthroughs in modulating the Ire1α-XBP1 pathway and identifying Glis3/Glis2 as therapeutic targets.
Notable contributions include demonstrating PKD2 re-expression reverses liver cysts in mouse models and identifying synthetic agents that induce cystic cell apoptosis. His work bridges molecular biology, genetics, and translational medicine to combat kidney diseases.
Awards: None explicitly listed in available texts. Grants: Collaborates on NIH-funded projects through Somlo Lab. Advising: No formal advisee list provided.
Labs/Teams: Active member of the Somlo Laboratory, part of the PKD Research Resource Consortium (PKD RRC). Engages in interdisciplinary efforts integrating systems immunology, engineering, and AI for healthcare innovation.