معرفی
Cai Qi is an Associate Research Scientist in the Department of Neuroscience at Yale School of Medicine. His research focuses on understanding the molecular mechanisms underlying autosomal dominant polycystic kidney disease (ADPKD), with an emphasis on polycystin signaling pathways and therapeutic interventions. His work integrates genetic models, chemical modulation, and cellular studies to explore cyst progression and kidney homeostasis. Key areas include cilia-dependent signaling, mitochondrial function, and the role of transcription factors like Glis2/3 in disease modulation.
Research highlights include developing novel mouse models to study polycystin-1 function, identifying Glis3 as a modifier of cyst progression, and exploring chemical inhibitors targeting the IRE1α-XBP1 pathway. He has also investigated synthetic agents to induce cystic cell apoptosis and the role of mitochondrial calcium signaling in ADPKD pathogenesis. Recent studies emphasize re-expression of PKD2 to reverse liver cysts and improve kidney function in mouse models.
No specific scientific awards are listed, but his contributions are reflected in high-impact publications spanning over two decades. His work bridges basic science and translational research, with a focus on developing therapeutic strategies for kidney diseases.