معرفی
Dr. Wei Mi is an Assistant Professor of Pharmacology at Yale University School of Medicine, with a secondary appointment in Molecular Biophysics and Biochemistry. He leads the Mi Lab, focusing on structural and mechanistic studies of membrane proteins involved in bacterial lipopolysaccharide (LPS) synthesis and regulation. His research aims to uncover novel antibiotic targets by elucidating how LPS biogenesis is regulated in Escherichia coli.
Dr. Mi holds a PhD in Structural Biology from Peking University (2008) and completed postdoctoral training at Purdue University, the University of Washington, and Harvard Medical School. His work employs cryo-electron microscopy (Cryo-EM), biochemical assays, and genetic approaches to study membrane protein complexes like the YejM/LapB complex and ATP-binding cassette transporters.
His research interests include antibiotic resistance mechanisms, membrane protein structures, and LPS transport regulation. Key publications include studies on LapB’s dual regulatory roles in LPS synthesis and structural analyses of KIT oncogenic mutants. Collaborators include David G. Schatz and Sangwon Lee.
- Awards:
- Dorsett L. Spurgeon Distinguished Research Award (2017)
- Harvard Medical School Outstanding Postdoctoral Fellow Award (2017)
- Mercedes-Benz Shujuan Scholarship (2004)
- Lab Focus: LPS biogenesis regulation, Cryo-EM structural biology, and drug target discovery.
