معرفی
Candice S. Klug is a Professor in the Department of Biophysics at the Medical College of Wisconsin (MCW). She holds significant leadership roles, including Director of the National Biomedical EPR Center (2016–present), Vice Chair for Research in Biophysics (2024–present), and past Chair of the Women's Faculty Council and Graduate School Curriculum Committee. She mentors junior faculty and collaborates on research projects, focusing on protein dynamics and membrane transport mechanisms using advanced spectroscopic techniques.
Her research explores protein conformation, membrane transport systems, and signal transduction, with emphasis on:
- Lipopolysaccharide (LPS) transport in Gram-negative bacteria (e.g., LptA/LptC proteins).
- Arrestin-mediated GPCR signaling and oligomerization dynamics.
- Bacterial antibiotic resistance mechanisms via kinase activation.
- Development of electron paramagnetic resonance (EPR) methodologies for structural biology.
Recent publications (15 most recent) predominantly investigate conformational changes in membrane transporters (e.g., Lpt system in E. coli) and arrestin signaling, utilizing site-directed spin labeling and EPR spectroscopy. Methodological innovations in EPR instrumentation for aqueous samples and kinase activation studies are recurring themes.
Dr. Klug leads the National Biomedical EPR Center, providing cutting-edge resources for structural biology research. She directs the Biophysics Graduate Program and mentors researchers in interdisciplinary projects spanning microbiology, biophysics, and biochemistry.
