معرفی
Urban Gullberg is a Professor at Lund University, affiliated with the Faculty of Medicine and the Division of Hematology and Clinical Immunology. He leads the research team on Transcriptional mechanisms for the Wilms’ tumor gene 1 (WT1) oncoprotein at the Lund University Cancer Centre (LUCC), focusing on the role of WT1 in leukemia pathogenesis.
- Research areas: Genome-wide binding of WT1 isoforms/mutants, transcriptional repression of tumor suppressors (e.g., IRF8), and mechanisms of leukemic cell proliferation.
- Methods: ChIP-Seq, promoter reporter assays, molecular profiling, and computational deconvolution of gene expression.
- Key findings: WT1 mutations disrupt transcriptional regulation, contributing to leukemia; identification of co-factors like ZNF224 and therapeutic targets.
His work aligns with UN Sustainable Development Goals for cancer research. He supervises PhD students and participates in educational activities related to medical cell biology and targeted therapies.
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