Sylvain Latour

Sylvain Latour leads a research team investigating lymphocyte activation mechanisms and their role in susceptibility to Epstein-Barr Virus (EBV) infections. His work focuses on immune response deficiencies leading to lymphoproliferative disorders and hemophagocytic lymphohistiocytosis. The team identified CTPS1's critical role in T-cell proliferation, linking its deficiency to increased EBV susceptibility.

• Key research areas: Genetic immunodeficiencies, EBV pathogenesis, T-cell metabolism, and immune response regulation
• Developing transgenic and KO mouse models to study disease mechanisms
• Supported by 'Fédération Enfants et Santé' for pediatric lymphoma studies

Team composition includes Professeure Capucine Picard (HDR), INSERM researchers, postdocs, and PhD students exploring signaling pathways and molecular defects in EBV responses. Current projects analyze replication/proliferation pathways in activated T-cells and investigate novel genetic diagnoses for EBV-related conditions.