معرفی
Professor David Booth is a Principal Research Fellow at the University of Sydney's Westmead Clinical School, affiliated with the Medicine department and The Westmead Institute for Medical Research. His research focuses on autoimmune diseases, particularly multiple sclerosis (MS), and explores genetic and epigenetic mechanisms linking Epstein-Barr virus infection, vitamin D pathways, and immune dysregulation. His work integrates genomic analysis, transcriptomics, and clinical data to identify therapeutic targets and biomarkers for MS and related conditions.
Research Themes:
- Investigation of how Epstein-Barr virus (EBV) interacts with MS genetic risk loci to drive pathogenesis
- Role of vitamin D signaling and DNA methylation in autoimmune susceptibility
- Immunological mechanisms linking viral infections to systemic lupus erythematosus and hepatitis
Key Projects:
- Developing biomarkers for predicting MS progression and therapy response
- Exploring epigenetic modifications (DNA methylation) in stem cells and immune cells
- Investigating the role of sex hormones in MS risk gene expression
Labs/Teams: Member of The Westmead Institute for Medical Research and the Charles Perkins Centre, collaborating on interdisciplinary projects involving immunology, genomics, and clinical translation.
