Sue Griffin

Sue Griffin is a Professor at the University of Arkansas for Medical Sciences, affiliated with the College of Medicine and the Department of Geriatrics. She holds secondary appointments in Neurobiology & Developmental Science, Pediatrics, Physiology and Cell Biology, and Psychiatry. Her research focuses on neuroinflammation, Alzheimer’s disease, and the role of apolipoprotein E (APOE) genotypes in neurodegenerative pathogenesis.

• NIH/National Institute on Aging R01AG084472 (2023–2028): Principal Investigator on neuroinflammation, protein aggregates, and autophagy rescue
• NIH R01HD037989 (2000–2007): Principal Investigator on cytokines in neurodegeneration and Down's syndrome
• NIH P01AG012411 (1995–2021): Principal Investigator on early events in Alzheimer pathogenesis

Her work spans interdisciplinary fields including neuroimmunology, protein homeostasis, and cytokine signaling. Publications highlight connections between inflammation (e.g., IL-1β), amyloid pathology, and genetic risk factors like APOE4. She has contributed to understanding neuroinflammatory mechanisms in Alzheimer’s, Parkinson’s, and Down’s syndrome.

Griffin’s recent articles focus on therapeutic strategies targeting autophagy, neuroinflammatory signaling in glioblastoma, and microbial contributions to Alzheimer’s neuropathology. Her research has been supported by NIH grants for over three decades, with collaborations across neurology, genetics, and pharmacology.

She is affiliated with the Institute on Aging and the Center for Translational Neuroscience. Her work has been cited in over 50 scientific concepts, including Alzheimer Disease, Epilepsy, and Apolipoproteins E.