Srinivas Ayyadevara

Srinivas Ayyadevara is an Associate Professor in the Department of Geriatrics at the University of Arkansas for Medical Sciences and a research scientist at the Central Arkansas Veterans Healthcare System. His work focuses on molecular mechanisms of neurodegenerative diseases, particularly Alzheimer's and Huntington's disease, emphasizing protein aggregation, autophagy, and neuroinflammation.

He investigates small-molecule therapeutics to disrupt pathological protein aggregates, including studies on thiadiazolidinone analogs and aspirin derivatives. His research also explores genetic pathways modulating longevity in Caenorhabditis elegans, such as PI3K-null mutants and CLEAR motif regulation.

• Current Grants:
  • NIH R01AG084472 (Co-Investigator): Neuroinflammation and ApoE4 in Alzheimer's
  • NIH R21AG075548 (PI): Mechanisms of PCSK9 in endothelial aging
  • NIH R01AG062254 (Co-PI): Common pathways in neurodegeneration
• Key Collaborations:
  • Sue Griffin (Alzheimer's pathology)
  • Robert Shmookler Reis (Aging genetics)
  • Jawahar Mehta (Cardiovascular-neurodegeneration links)