معرفی
Sten Eirik W. Jacobsen is the Bass Professor of Developmental and Stem Cell Biology at the Radcliffe Department of Medicine (University of Oxford). He also leads a research lab at the Department of Medicine, Huddinge and Department of Cell and Molecular Biology at the Karolinska Institute in Sweden. His work focuses on understanding hematopoietic stem and progenitor cell biology, particularly how normal lineage commitment pathways are disrupted in hematological malignancies like myelodysplastic syndromes (MDS) and myeloproliferative neoplasms.
Education: Jacobsen holds a PhD and M.D..
Research Interests: The Jacobsen Lab employs advanced genetic tools and single-cell molecular analysis to study:
- Dynamics of stem/progenitor cells in unperturbed and challenged hematopoiesis
- Genomic lesions' impact on lineage commitment in blood disorders
- Clonal hematopoiesis evolution in pre-leukemic/leukemic contexts
- Novel therapies targeting leukemic stem cells and regenerative blood systems
Grants & Collaborations: His research is funded by the BBSRC, MRC UK, Swedish Research Council, and Swedish Cancer Society. Key collaborators include Prof Claus Nerlov, Prof Adam Mead, and Prof Marella de Bruijn.
Labs/Teams: Leads the Jacobsen Group within the MRC Molecular Haematology Unit and collaborates with the MRC Weatherall Institute of Molecular Medicine. His team includes researchers like Bishan Wu (Research Assistant) and Affaf Aliouat (Postdoctoral Researcher).
